Selected Abstracts and Meetings Proceedings:

Eycke Boehme, Christiane Spies, Georg Grossmann, and Joachim Herz
Stimulation of Soluble Guanylate Cyclase by Sydnonimines: Relaxants of Smooth Muscle and Inhibitors of Platelet Aggregation.
Naunyn-Schmiedebergs Arch. Pharmacol. 316: 26  (1981)

Joachim Herz, Ute Hamann and Keith K. Stanley
A liver mRNA with high sequence homology to the LDL-receptor.
J. Cell Biol. 105, 236a (1987)

Joachim Herz, David Clouthier, Michael S. Brown, Joseph L. Goldstein, and Robert E. Hammer  
The LDL Receptor Supergene Family.
Keystone Symposia, Supplement 16F, 37 (1992)

Joachim Herz, Robert C. Kowal, Michael S. Brown, and Joseph L. Goldstein
Cellular uptake of lipoproteins through LRP is apo E-dependent
J. Drug Devel. 3 (suppl. 1), 71-76 (1990)

Joachim Herz
The Low Density Lipoprotein Receptor-related Protein: An Endocytic Receptor with Dual Ligand Specificity.
in "Hepatic Endocytosis of Lipids and Proteins", E. Windler and H. Greten, eds., Zuckschwerdt Verlag, pp. 46 - 52 (1992)

Book Contributions:

Thomas E. Willnow and Joachim Herz
Homologous Recombination for Gene Replacement in Mouse Cell Lines.
In: Methods in Cell Biology 43: Protein Expression in Animal Cells.  M. Roth, ed.,  Academic Press,  San Diego,  Vol. 43, 305-334 (1994)

Thomas E. Willnow, Shun Ishibashi and Joachim Herz
Genetic Manipulation of Lipoprotein Receptors:  Implications for Lipid Metabolism and Atherosclerosis.
In: Cardiovascular Disease '94: Cellular and Molecular Mechanisms, Prevention, Treatment.  L. Gallo, ed., Plenum Press, New York, 307-312 (1995)

Thomas E. Willnow and Joachim Herz
Gene Inactivation by Homologous Recombination - Animal Models of Plasma Lipoprotein Disorders
Chapter 8, In: Concepts in Gene Therapy.  Michael Strauss and John Barranger, eds., Walter de Gruyter Berlin, New York, 123-140 (1997)

Joachim Herz
Physiology of the LDL Receptor-Related Protein: Functions in ApoE-Mediated Remnant Metabolism and Other Biological Processes
in "Lipoproteins in Health and Disease"; Betteridge, Illingworth, and Shepherd, eds., Edward and Arnold, London;  Chapter 18, pp. 333-359 (1999)

Joachim Herz, Uwe Beffert, Thomas Hiesberger, Michael Gotthardt
ApoE Receptors in the Brain:  Novel Signaling Pathways with Potential Relevance for Alzheimer’s Disease
In “Research and Perspectives in Alzheimer’s Disease”; Beyreuther, Christensen, Masters, eds.;  Springer Verlag, Berlin, Heidelberg, Hong Kong, London, Milan, Paris, Tokyo (2001)

Joachim Herz
Lipoprotein Receptors.
Encyclopedia of Molecular Medicine, T. Creighton, ed., John Wiley and Sons

Hans H. Bock, Petra May, Joachim Herz
Lipoprotein Transport.
In "Transgenic Models in Pharmacology"; Stefan Offermanns, Lutz Hein, eds.; Springer Verlag, Berlin, Heidelberg, Hong Kong, London, Milan, Paris, Tokyo; Part 4. Cardiovascular System, pp. 397 - 421 (2003)

Hans H. Bock, Joachim Herz, Petra May
Conditional AnimalModels for the Study of LipidMetabolism and Lipid Disorders.
HEP178,  403–435 (2007) - Springer-Verlag Berlin Heidelberg

Hans H. Bock and Joachim Herz
Apolipoprotein E receptor 2 and very low density lipoprotein receptor: An overview.
In Fatemi, S.H. (ed), Reelin Glycoprotein, Structure, Biology and Roles in Health and Disease. Springer, New York, pp. 15-35  (2008)

Peer Reviewed Articles:

Eycke Boehme, Rupert Gerzer, Gerd Grossmann, Joachim Herz, Alexander Mülsch, Cornelie Spies, and Günter Schultz.
Regulation of Soluble Guanylate Cyclase Activity.
Hormones and Cell Regulation 7, 147-161, (1983)

Eycke Boehme, Georg Grossmann, Joachim Herz, Alexander Muelsch, Christiane Spiess, and Günter Schultz
Regulation of cyclic GMP formation by soluble guanylate cyclase: stimulation by NO-containing compounds.
Adv. Cyclic Nucleotide Protein Phosphorylation Res.  17: 259-266  (1984)

Harald Haymerle, Joachim Herz, Giorgio M. Bressan, Rainer Frank, and Keith K. Stanley
Efficient construction of cDNA libraries in plasmid expression vectors using an adaptor strategy.
Nucleic Acids Res. 14,  8615-8624 (1986)

Keith K. Stanley and Joachim Herz
Topological mapping of complement component C9 by recombinant DNA techniques suggests a novel mechanism for its insertion into target membranes.
EMBO J. 6,  1951-1957 (1987)

Dieter Jenne, Claudine Rey, Daniele Masson, Keith K. Stanley, Joachim Herz, Geert Plaetinck, and Jürg Tschopp
cDNA cloning of granzyme C,  a granule-associated serine protease of cytolytic T lymphocytes.
J. Immunol. 140,  318-323 (1988)

D. Koesling, J. Herz, H. Gausepohl, F. Niroomand, K.-D. Hinsch, A. Mülsch, E. Böhme, G. Schultz, and R. Frank
The primary structure of the 70 kDa subunit of bovine soluble guanylate cyclase.
FEBS letters 239 (1): 29-34  (1988)

Joachim Herz, Ute Hamann, Sissel Rogne, Ola Myklebost, Heinrich Gausepohl, and Keith K. Stanley
Surface location and high affinity for calcium of a 500 kd liver membrane protein closely related to the LDL receptor suggest a physiological role as lipoprotein receptor.
EMBO J.  7,  4119-4127  (1988)

Ola Myklebost, Kristina Arheden, Sissel Rogne, Ad Geurts van Kessel, Nils Mandahl, Joachim Herz, Keith Stanley, Sverre Heim, and Felix Mitelman
The Gene for the Human Putative apoE Receptor is on Chromosome 12 in the Segment q13-14.
Genomics  5,  65-69  (1989)

Ulrike Beisiegel, Wilfried Weber, Gudrun Ihrke, Joachim Herz, and Keith K. Stanley
The LDL receptor-related protein, LRP, is an apolipoprotein E-binding protein.
Nature  341,  162-164  (1989)

Robert C. Kowal, Joachim Herz, Joseph L. Goldstein, Victoria Esser, and Michael S. Brown
Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apo E-enriched lipoproteins.
Proc. Natl. Acad. Sci.  86,  5810-5814  (1989)

Karin Roemisch, Jane Webb, Joachim Herz, Siegfried Prehn, Rainer Frank, Martin Vingron, and Bernhard Dobberstein
Homology of 54K protein of signal-recognition particle, docking protein and two E.coli proteins with putative GTP-binding domains.
Nature  340,  478-482 (1989)

Heike Kuett, Joachim Herz, and Keith K. Stanley
Structure of the low density lipoprotein receptor-related protein (LRP) promoter.
Biochem. Biophys. Acta  1009 (3): 229-236 (1989)

Siegfried Prehn, Joachim Herz, Enno Hartmann, Teymuras V. Kurzchalia, Rainer Frank, Karin Roemisch, Bernhard Dobberstein, and Tom A. Rapoport
Structure and Biosynthesis of the Signal Sequence Receptor.
Eur. J. Biochem. 188, 439-445 (1990)

Joachim Herz, Robert C. Kowal, Joseph L. Goldstein, and Michael S. Brown
Proteolytic processing of the 600 kd low density lipoprotein receptor-related protein (LRP) occurs in a trans-Golgi compartment.
EMBO J. 9,  1769-1776 (1990)

Robert C. Kowal, Joachim Herz, Karl H. Weisgraber, Robert W. Mahley, Michael S. Brown, and Joseph L. Goldstein
Opposing effects of Apolipoproteins E and C on Lipoprotein Binding to Low Density Lipoprotein Receptor-related Protein.
J. Biol. Chem. 265, 10771-10779 (1990)

Joachim Herz, Robert C. Kowal, Y.K. Ho, Michael S. Brown, and Joseph L. Goldstein
Low density lipoprotein receptor-related protein (LRP) mediates endocytosis of monoclonal antibodies in cultured cells and rabbit liver.
J. Biol. Chem. 265, 21355-21362 (1990)

Karl H. Weisgraber, Robert W. Mahley, Robert C. Kowal, Joachim Herz, Joseph L. Goldstein, and Michael S. Brown
Apolipoprotein C-I Modulates the Interaction of Apolipoprotein E with ß-Migrating Very Low Density Lipoproteins (ß-VLDL) and Inhibits Binding of ß-VLDL to Low Density Lipoprotein Receptor-related Protein.
J. Biol. Chem. 265, 22453-22459 (1990)

Joachim Herz, Nicholas Flint, Keith K. Stanley, Rainer Frank, and Bernhard Dobberstein
The 68 kDa protein of signal recognition particle contains a glycine-rich region also found in certain RNA-binding proteins.
FEBS letters  276 (1,2), 103-107 (1990)

Dirk Goerlich, Siegfried Prehn, Enno Hartmann, Joachim Herz, Albrecht Otto, Regine Kraft, Martin Wiedmann, Siegne Knespel, Bernhard Dobberstein, and Tom A. Rapoport
The Signal Sequence Receptor Has a Second Subunit and Is Part of a Translocation Complex in the Endoplasmic Reticulum as Probed by Bifunctional Reagents.
J. Cell Biol. 111,  2283-2294  (1990)

Michael S. Brown, Joachim Herz, Robert C. Kowal, and Joseph L. Goldstein
The low density lipoprotein receptor-related protein: double agent or decoy?
Current Opinion in Lipidology 2,  65-72  (1991)

Joachim Herz, Joseph L. Goldstein, Dudley K. Strickland, Y.K. Ho, and Michael S. Brown
39-kDa Protein Modulates Binding of Ligands to Low Density Lipoprotein Receptor-related Protein/a2-Macroglobulin Receptor.
J. Biol. Chem. 266, 21232-21238 (1991)

Kim Orth, Edwin L. Madison, Mary-Jane Gething, Joseph F. Sambrook, and Joachim Herz
Complexes of t-PA and its serpin inhibitor PAI-1  are internalized via  the LRP/a2-Macroglobulin Receptor.
Proc. Natl. Acad. Sci. 89,  7422-7426  (1992)

Sylvie Paulien, Avery A. Sandberg, Joachim Herz, and Robert M. Gemmill  
Putative Apolipoprotein Receptor Gene (LRP, a2MR) Is Not Rearranged in Either Myxoid Liposarcoma or Lipomas with Translocations in 12q13-14.
Canc. Gen. Cytogen. 60, 125-130  (1992)

Joachim Herz, David E. Clouthier, Robert E. Hammer
LDL Receptor-Related Protein Internalizes and Degrades uPA/PAI-1 Complexes and Is Essential for Embryo Implantation.
Cell 71, 411 - 421 (1992)  [Correction Cell 73, 428 (1993)]

Thomas E. Willnow, Joseph L. Goldstein, Kim Orth, Michael S. Brown, and Joachim Herz
Low Density Lipoprotein Receptor-Related Protein (LRP) and gp330 Bind Similar Ligands, Including Plasminogen Activator/Inhibitor Complexes and Lactoferrin, An Inhibitor of Chylomicron Remnant Clearance.
J. Biol. Chem.  267,  26172 - 26180 (1992)

Olivier Descamps, David Bilheimer, and Joachim Herz
Insulin Stimulates Receptor-mediated Uptake of Apo E-enriched Lipoproteins and Activated a2-Macroglobulin in Adipocytes.
J. Biol. Chem.  268,  974 - 981  (1993)

Joachim Herz and Robert D. Gerard
Adenovirus-mediated Transfer of Low Density Lipoprotein Receptor Gene Acutely Accelerates Cholesterol Clearance In Normal Mice
Proc. Natl. Acad. Sci.  90,  2812-2816  (1993)

Joachim Herz
The LDL Receptor-related Protein - Portrait of a Multifunctional Receptor.
Current Opinion in Lipidology 4,  107-113  (1993)

Shun Ishibashi, Michael S. Brown, Joseph L. Goldstein, Robert D. Gerard, Robert E. Hammer, and Joachim Herz
Hypercholesterolemia In LDL Receptor Knockout Mice And Its Reversal By Adenovirus-Mediated Gene Transfer.
J. Clin. Invest. 92,  883-893 (1993)

Thomas W. Rosahl, Martin Geppert, Diane Spillane, Joachim Herz, Robert E. Hammer, Robert C. Malenka, and Thomas C. Südhof
Short-Term Plasticity Is Altered in Mice Lacking Synapsin I.
Cell 75, 661-670 (1993)

Monty Krieger and Joachim Herz
Structures and Functions of Multiligand Lipoprotein Receptors:  Macrophage Scavenger Receptors and LDL Receptor-Related Protein (LRP)
Ann. Rev. Biochem. 63,  601-637  (1994)

Joachim Herz and Thomas E. Willnow
Functions of the LDL Receptor Gene Family.
Annals N.Y. Acad. Sci. 737, 14-19 (1994)

Thomas E. Willnow and Joachim Herz
Genetic Deficiency in Low Density Lipoprotein Receptor-related Protein (LRP) Confers Cellular Resistance to Pseudomonas Exotoxin A - Evidence that LRP Is Required for Uptake and Degradation of Multiple Ligands.
J. Cell Science 107, 719-726 (1994)

Shun Ishibashi, Joseph L. Goldstein, Michael S. Brown, Joachim Herz, and Dennis K. Burns
Massive Xanthomatosis and Atherosclerosis in Cholesterol-Fed LDL Receptor-Negative Mice.
J. Clin. Invest. 93, 1885-1893 (1994)

Shun Ishibashi, Joachim Herz, Nobuyo Maeda, Joseph L. Goldstein, and Michael S. Brown
The two-receptor model of lipoprotein clearance:  Tests of the hypothesis in knockout mice lacking the LDL receptor, apoE, and both proteins.
Proc. Natl. Acad. Sci. USA 91, 4431-4435  (1994)

Hiroshi Mokuno, Sandra Brady, Leila Kotite, Joachim Herz, and Richard J. Havel
Effect of the 39-kDa Receptor-associated Protein on the Hepatic Uptake and Endocytosis of Chylomicron Remnants and Low Density Lipoproteins in the Rat.
J. Biol. Chem. 269, 13238-13243  (1994)

Thomas E. Willnow, Kim Orth, and Joachim Herz
Molecular Dissection of Ligand Binding Sites on the LDL Receptor-related Protein.
J. Biol. Chem. 269, 15827-15832  (1994)

Thomas E. Willnow, Zeqi Sheng, Shun Ishibashi, and Joachim Herz
Inhibition of Hepatic Chylomicron Remnant Uptake by Gene Transfer of A Receptor Antagonist.
Science 264, 1471-1474  (1994)

Kim Orth, Thomas Willnow, Joachim Herz, Mary-Jane Gething, and Joseph Sambrook
Low Density Lipoprotein Receptor-related Protein (LRP) Is Necessary for the Internalization of Both Tissue-type Plasminogen Activator-Inhibitor-1 (t-PA:PAI-1) Complexes and Free Tissue-type Plasminogen Activator (t-PA).
J. Biol. Chem. 269, 21117-21122 (1994)

Shun Ishibashi, Robert E. Hammer, and Joachim Herz
Asialoglycoprotein Receptor-Deficiency in Mice Lacking the Minor Receptor Subunit.
J. Biol. Chem. 269, 27803-27806 (1994)

Wolfgang Poller, Thomas E. Willnow, Jan Hilpert, and Joachim Herz
Differential Recognition of a1-Antitrypsin/Elastase and a1 -Antichymotrypsin/Cathepsin G - Complexes by the Low Density Lipoprotein Receptor-related Protein.
J. Biol. Chem. 270, 2841-2845 (1995)

Joachim Herz and Thomas E. Willnow
Lipoprotein and Receptor Interactions In Vivo.
Current Opinion in Lipidology 6, 97-103 (1995)

Yasunori Osono, Laura A. Woollett, Joachim Herz, and John M. Dietschy
Role of the Low Density Lipoprotein Receptor in the Flux of Cholesterol Through the Plasma and Across the Tissues of the Mouse.
J. Clin. Invest. 95, 1124-1132 (1995)

Thomas E. Willnow, Scott A. Armstrong, Robert E. Hammer, and Joachim Herz
Functional Expression of Low Density Lipoprotein (LDL) Receptor-related Protein (LRP) Is Controlled By Receptor-Associated Protein (RAP) In Vivo.
Proc. Natl. Acad. Sci. USA 92, 4537-4541 (1995)

Joachim Herz, Shi-Qiang Qiu, Adair Oesterle, Harshini V. DeSilva, Shahida Shafi, and Richard J. Havel
Initial hepatic removal of chylomicron remnants is unaffected but endocytosis is delayed in mice lacking the low density lipoprotein receptor.
Proc. Natl. Acad. Sci. USA 92, 4611-4615 (1995)

Joachim Herz
Erforschung der Ursachen und Behandlung der Atherosklerose:  Tiermodelle sind unverzichtbar.
Med-Report 8, 3 (1995)

Thomas W. Rosahl, Diane Spillane, Markus Missler, Joachim Herz, David K. Selig, Joachim R. Wolff, Robert E. Hammer, Robert C. Malenka, and Thomas C. Südhof
Essential functions of synapsin I and synapsin II in synaptic vesicle regulation.
Nature 375, 488- 493 (1995)

Thomas E. Willnow and Joachim Herz
Animal models for disorders of hepatic lipoprotein metabolism.
J. Mol. Med. 73, 213-220 (1995)

Masaaki Narita, Guojun Bu, Joachim Herz, and Alan L. Schwartz
Two Receptor Systems are Involved in the Plasma Clearance of Tissue-type Plasminogen Activator (t-PA) In Vivo.
J. Clin. Invest. 96, 1164-1168 (1995)

Philip K. Frykman, Michael S. Brown, Tokuo Yamamoto, Joseph L. Goldstein, and Joachim Herz
Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor.
Proc. Natl. Acad. Sci. USA 92, 8453-8457 (1995)

Masaaki Narita, Guojun Bu, Gillian M. Olins, Darryl A. Higuchi, Joachim Herz, George J. Broze, Jr., and Alan L. Schwartz
Two Receptor Systems Are Involved in the Plasma Clearance of Tissue Factor Pathway Inhibitor in Vivo.
J. Biol. Chem. 270, 24800-24804 (1995)

Laura A. Woollett, Yasunori Osono, Joachim Herz, and John M. Dietschy
Apolipoprotein E competitively inhibits receptor-dependent low density lipoprotein uptake by the liver but has no effect on cholesterol absorption or sythesis in the mouse.
Proc. Natl. Acad. Sci. USA 92, 12500-1504 (1995)

Thomas E. Willnow, Joan M. Moehring, Noel M. Inocencio, Thomas J. Moehring, and Joachim Herz
The low density lipoprotein receptor-related protein (LRP) is processed by furin in vivo and in vitro.
Biochemical J. 313, 71-76 (1996)

Thomas E. Willnow, Astrid Rohlmann, Jay Horton, Hideo Otani, Jürgen R. Braun, Robert E. Hammer and Joachim Herz
RAP, a specialized chaperone, prevents ligand-induced ER-Retention and degradation of LDL receptor-related endocytic receptors.
EMBO J. 15,  2632-2639 (1996)

E. Sehayek, X.X. Wang, I. Vlodavsky, R. Avner, H. Levkovitz, T. Olivecrona, G. Olivecrona, T.E. Willnow, J. Herz, S. Eisenberg
Heparan Sulfate-Dependent and Low Density Lipoprotein Receptor-Related Protein-Dependent Catabolic Pathways for Lipoprotein Lipase in Mouse Embryonic Fibroblasts.
Israel Journal of Medical Sciences 32, 449-454 (1996)

Shun Ishibashi, Margrit Schwarz, Philip K. Frykman, Joachim Herz and David W. Russell
Disruption of cholesterol 7a-hydroxylase gene in mice. I. Postnatal lethality reversed by bile acid and vitamin supplementation.
J. Biol. Chem. 271, 18017-18023 (1996)

Margrit Schwarz, Erik G. Lund, Kenneth D. R. Setchell, Herbert J. Kayden, J. E. Zerwekh, Ingemar Bjorkhem, Joachim Herz and David W. Russell
Disruption of cholesterol 7a-hydroxylase gene in mice. II. Bile acid deficiency is overcome by induction of oxysterol 7a-hydroxylase.
J. Biol. Chem. 271, 18024-18031 (1996)

Thomas E. Willnow, Jan Hilpert, Scottt A. Armstrong, Astrid Rohlmann, Robert E. Hammer, Dennis K. Burns and Joachim Herz
Defective forebrain development in mice lacking gp330/ megalin.
Proc. Natl. Acad. Sci. USA  93, 8460-8464 (1996)

Jürgen R. Braun, Thomas E. Willnow, Shun Ishibashi, Gilbert Ashwell, and Joachim Herz
The Major Subunit of the Asialoglycoprotein Receptor is Expressed on the Hepatocellular Surface in Mice Lacking the Minor Receptor Subunit.
J. Biol. Chem. 271, 21160-21166 (1996)

Ilka Warshawsky, Joachim Herz, George J. Broze, Jr., and Alan L. Schwartz
The Low Density Lipoprotein Receptor-related Protein Can Function Independently from Heparan Sulfate Proteoglycans in Tissue Factor Pathway Inhibitor Endocytosis.
J. Biol. Chem.  271, 25873-25879 (1996)

Photini Sinnis, Thomas E. Willnow, Marcelo R.S. Briones, Joachim Herz, and Victor Nussenzweig
Remnant Lipoproteins Inhibit Malaria Sporozoite Invasion of Hepatocytes.
J. Exp. Med. 184, 945-954 (1996)

Astrid Rohlmann, Michael Gotthardt, Thomas E. Willnow, Robert E. Hammer and Joachim Herz
Sustained Somatic Gene Inactivation By Viral Transfer of Cre Recombinase.
Nature Biotechnology  14,  1562-1565 (1996)

Vardiella L. Meiner, Sylvaine Cases, Heather M. Myers, Eric R. Sande, Stefano Bellosta, Morris Schambelan, Robert E. Pitas, James McGuire, Joachim Herz, Robert V. Farese, Jr.
Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: Evidence suggesting multiple cholesterol esterification enzymes in mammals.
Proc. Natl. Acad. Sci. USA 93, 14041-14046 (1996)

Joachim Herz, Thomas E. Willnow, Robert V. Farese, Jr.
Cholesterol, Hedgehog, and embryogenesis.
Nature Genetics  15, 123-124 (1997)

Robert C. Johnson, Susan M. Chapman, Zhao-Ming Dong, Jose M. Ordovas, Tanya N. Mayadas, Joachim Herz, Richard O. Hynes, Ernst J. Schaefer, and Denisa D. Wagner
Absence of P-Selectin Delays Fatty Streak Formation in Mice.
J. Clin. Invest. 99, 1037-43 (1997)

Christian Brandes, Sabine Novak, Walter Stockinger, Joachim Herz,Wolfgang J. Schneider, and Johannes Nimpf
Avian and murine LR8B and human apolipoprotein E receptor 2: differentially spliced products from corresponding genes.
Genomics 42, 185-91 (1997)

Michael S. Brown,  Joachim Herz, and Joseph L. Goldstein
LDL-Receptor Structure - Calcium Cages, Acid Baths and Recycling Receptors.
Nature 388, 629-630 (1997)

Deltef Storm, Joachim Herz, Peter Trinder, and Michael Loos
C1-Inhibitor-C1s Complexes Are Internalized and Degraded by the Low Density Lipoprotein Receptor-related Protein.
J. Biol. Chem. 272, 31043-31050  (1997)

Hitoshi Shimano, Iichiro Shimomura, Robert E. Hammer, Joachim Herz, Joseph L. Goldstein, Michael S. Brown, and Jay D. Horton
Elevated Levels of SREBP-2 and Cholesterol Synthesis in Livers of Mice Homozygous for a Targeted Disruption of the SREBP-1 Gene.
J. Clin. Invest. 100, 2115-2124 (1997)

Astrid Rohlmann, Michael Gotthardt, Robert E. Hammer, and Joachim Herz
Inducible Inactivation of Hepatic LRP Gene By Cre-Mediated Recombination Confirms Role of LRP in Clearance of Chylomicron Remnants.
J. Clin. Invest. 101, 689-695 (1998)

Robert V. Farese, Jr., and Joachim Herz
Cholesterol and Embryogenesis.
Trends in Genetics 14, 115-120 (1998)

Thomas Hiesberger, Silke Hüttler, Astrid Rohlmann, Wolfgang Schneider, Konrad Sandhoff, and Joachim Herz
Cellular Uptake of Saposin (SAP) Precursor and Lysosomal Delivery by the Low Density Lipoprotein Receptor-Related Protein (LRP)
EMBO J. 17, 4617-4625 (1998)

Murielle M. Véniant, Constance H. Zlot, Rosemary L. Walzem, Vincenzo Pierotti, Robert Driscoll, David Dichek, Joachim Herz, and Stephen G. Young
Lipoprotein Clearance Mechanisms in LDL Receptor-Deficient "Apo-B48-only" and "Apo-B100-only" Mice
J. Clin. Invest. 102, 1559-1568  (1998)

Marion Trommsdorff, Jean-Paul Borg, Benjamin Margolis, and Joachim Herz
Interaction of cytosolic adaptor proteins with neuronal apoE receptors and the amyloid precursor protein.
J. Biol. Chem. 273, 33556-33560 (1998)

Joachim Herz and Robert V. Farese, Jr.
The LDL Receptor Gene Family, Apolipoprotein B and Cholesterol In Embryonic Development.
Journal of Nutrition 129, 473S-475S (1999)

Bart J.M. van Vlijmen and Joachim Herz
Gene Targets and Approaches for Raising HDL.
Circulation 99, 12-14 (1999)

Anders Nykjaer, Duska Dragun, Diego Walther, Henrik Vorum, Christian Jacobsen, Joachim Herz, Flemming Melsen, Erik Isloe Christensen, and Thomas E. Willnow
An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3.
Cell 96, 507-515 (1999)

Marion Trommsdorff, Michael Gotthardt, Thomas Hiesberger, John Shelton, Walter Stockinger, Johannes Nimpf, Robert E. Hammer, James A. Richardson, and Joachim Herz
Reeler/Disabled-Like Disruption of Neuronal Migration in Knockout Mice Lacking the VLDL receptor and ApoE receptor-2.
Cell 97, 689-701 (1999)

Atsushi Sato, Yoshimi Shimada, Joachim Herz, Tokuo Yamamoto, and Hisato Jingami
39-kDa receptor-associated protein (RAP) facilitates secretion and ligand binding of extracellular region of very-low-density-lipoprotein receptor: implications for a distinct pathway from low-density-lipoprotein receptor.
Biochem. J. 341, 377-383 (1999)

Thomas E. Willnow, Anders Nykjaer, Joachim Herz
Lipoprotein receptors: new roles for ancient proteins
Nature Cell Biology  1, 157-162 (1999)

Thomas Hiesberger, Marion Trommsdorff, Brian W. Howell, Andre Goffinet, Marc C. Mumby, Jonathan A. Cooper, and Joachim Herz
Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of the adaptor protein Disabled-1 and modulates tau phosphorylation.
Neuron 24, 481-489 (1999)

Bart J.M. van Vlijmen, Astrid Rohlmann, André Bensadoun, Shallee Page, I. Sophie T. Bos, Theo J.C. van Berkel, Louis M. Havekes, and Joachim Herz
An Extrahepatic RAP-Sensitive Mechanism Is Involved in the Metabolism of Triglyceride-Rich Lipoproteins.
J. Biol. Chem., 274, 35219–35226 (1999)

Narimon Honarpour, Chunying Du, James A. Richardson, Robert E. Hammer, Xiaodong Wang, Joachim Herz
Adult Apaf-1-Deficient Mice Exhibit Male Infertility.
Developmental Biology  218, 248-258 (2000)

Patricia Marshall, Astrid Rohlmann, Victor Nussenzweig, Joachim Herz, and Photini Sinnis
Plasmodium Sporozoites Invade Cells with Targeted Deletions in the LDL Receptor Related Protein (LRP).
Mol. Biochem. Parasitol.  106, 293-298 (2000)

Joachim Herz, Michael Gotthardt, and Thomas E. Willnow
Cellular Signaling By Lipoprotein Receptors.
Current Opinion in Lipidology 11, 161-166 (2000)

Michael Gotthardt, Marion Trommsdorff, Matthew F. Nevitt, John Shelton, James A. Richardson, Walter Stockinger, Johannes Nimpf, and Joachim Herz
Interactions of the low density lipoprotein (LDL) receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction.
J. Biol. Chem. 275, 25616-25624 (2000)

Walter Stockinger, Christian Brandes, Daniela Fasching, Marcela Hermann, Michael Gotthardt, Joachim Herz, Wolfgang J. Schneider, and Johannes Nimpf
The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and 2.
J. Biol. Chem. 275, 25625-25632 (2000)

Joachim Herz and Uwe Beffert
Apolipoprotein E receptors: linking brain development and Alzheimer disease.
Nature Neuroscience Rev. 1, 51-58 (2000)

Brian W. Howell and Joachim Herz
The LDL Receptor Gene Family: Signaling Functions in Development.
Current Opinion in Neuroscience 11, 74-81 (2001)

Joachim Herz
Lipoprotein receptors: Beacons to neurons?
Trends in Neuroscience 24, 193-195 (2001)

Joachim Herz
The LDL Receptor Gene Family: (Un)Expected Signal Transducers in the Brain
Neuron 29, 571-581 (2001)

Joachim Herz
Deconstructing the LDL receptor – a rhapsody in pieces
Nature Stuctural Biology 8, 476-8 (2001)

Narimon Honarpour, Katsuhiko Tabuchi, Jeffrey M. Stark, Robert E. Hammer, Thomas C. Sudhof, Luis F. Parada, Xiaodong Wang, James A. Richardson, and Joachim Herz
Embryonic neuronal death due to neurotrophin and neurotransmitter deprivation occurs independent of Apaf-1.
Neuroscience 106(2):263-74 (2001)

Narimon Honarpour, Sandra Gilbert, Bruce Lahn, Xiaodong Wang, and Joachim Herz
Apaf-1 Deficiency and Neural Tube Closure Defects in forebrain-overgrowth (fog) Mice.
Proc. Natl. Acad. Sci., 98(17):9683-7 (2001)

Joachim Herz and Dudley K. Strickland
LRP: a multifunctional scavenger and signaling receptor.
J. Clin. Invest. 108(6):779-84  (2001)

Carl Gebhardt, Domenico Del Turco, Alexander Drakew, Albrecht Tielsch, Joachim Herz, Michael Frotscher, and Thomas Deller
Abnormal positioning of granule cells alters afferent fiber distribution in the mouse fascia dentata: Morphologic evidence from reeler, apolipoprotein E receptor 2-, and very low density lipoprotein receptor knockout mice.
J Comp Neurol.  445, 278-92 (2002)

Joachim Herz and Hans. H. Bock
Lipoprotein Receptors in the Nervous System
Ann. Rev. Biochem. 71, 405-34 (2002)

Philippe Boucher, Pingsheng Liu, Michael Gotthardt, Thomas Hiesberger, Richard G. W. Anderson, and Joachim Herz
PDGF mediates tyrosine phosphorylation of the cytoplasmic domain of the LDL receptor-related protein (LRP) in caveolae.
J. Biol. Chem., 277,  15507-13  (2002)

Petra May, Y. Krishna Reddy, and Joachim Herz
Proteolytic processing of LRP mediates regulated release of its intracellular domain.
J. Biol. Chem. 277, 18736-43  (2002)

Rita Holtwick, Michael Gotthardt, Boris Skryabin, Martin Steinmetz, Regine Potthast, Bernd Zetsche, Robert E. Hammer, Joachim Herz, and Michaela Kuhn
Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure.
Proc. Natl. Acad. Sci. 99, 7142-7147  (2002)

Alexander Drakew, Thomas Deller, Bernd Heimrich, Carl Gebhardt, Domenico Del Turco, Albrecht Tielsch, Eckart Förster, Joachim Herz, and Michael Frotscher
Dentate Granule Cells in Reeler Mutants and VLDLR and ApoER2 Knockout Mice.
Exp. Neurol. 176, 12-24 (2002)

Edwin J. Weeber, Uwe Beffert, Chris Jones, Jill M. Christian, Eckart Förster, J. David Sweatt, and Joachim Herz     
Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning.
J Biol Chem., 277, 39944-39952 (2002)

Uwe Beffert, Gerardo Morfini, Hans. H. Bock, Huichuan Reyna, Scott T. Brady, and Joachim Herz
Reelin-mediated signaling locally regulates PKB/Akt and GSK-3ß
J. Biol.Chem. 277, 49958-49964 (2002)

Jochen Brich, Feng-Shiun Shie, Brian W. Howell, Renhua Li, Katalin Tus, Edward K. Wakeland, Lee-Way Jin, Marc Mumby, Gary Churchill, Joachim Herz, and Jonathan A. Cooper
Genetic modulation of tau phosphorylation in the mouse
J. Neuroscience 23, 187-192 (2003)         Alzforum commentary

Hans H. Bock and Joachim Herz
Reelin Activates Src Family Tyrosine Kinases in Neurons
Current Biology 13, 18-26 (2003)

Peter Marschang and Joachim Herz
Mouse models as tools for dissecting disorders of lipoprotein metabolism
Seminars in Cell and Developmental Biology 14, 25-35 (2003)

Michael Gotthardt, Robert E. Hammer, Norbert Hübner, Jan Monti, Christian C. Witt, Mark McNabb, James A. Richardson, Henk Granzier, Siegfried Labeit, and Joachim Herz
Conditional expression of mutant M-line titins results in cardiomyopathy with altered sarcomere structure.
J Biol Chem. 278, 6059-6065 (2003)

Niels Bovenschen, Joachim Herz, Jos M. Grimbergen, Peter J. Lenting, Louis M. Havekes, Koen Mertens, and Bart J. M. van Vlijmen
Elevated plasma factor VIII in a mouse model of low-density lipoprotein receptor related protein deficiency
Blood 101, 3933-3939 (2003)

Joachim Herz and Peter Marschang
Coaxing the LDL Receptor Family into the Fold
Cell 112, 289-292 (2003)
Marc-Estienne Roehrich, Vincent Mooser, Vincent Lenain, Joachim Herz, Johannes Nimpf, Salman Azhar, Martine Bideau, Alessandro Capponi, Pascal Nicod, Jacques-Antoine Haefliger, and Gérard Waeber
Insulin-secreting ß-cell dysfunction induced by human lipoproteins
J. Biol. Chem. 278, 18368-18375 (2003)
Petra May, Hans H. Bock, and Joachim Herz
Integration of Endocytosis and Signal Transduction by Lipoprotein Receptors
Sci. STKE 2003, pe12 (2003).

Philippe Boucher, Michael Gotthardt, Wei-Ping Li, Richard G.W. Anderson, Joachim Herz
LRP: Role in Vascular Wall Integrity and Protection from Atherosclerosis
Science 300, 329-332 (2003)           Center Times

Karl Heinz Weiss, Celine Johanssen, Albrecht Tielsch, Joachim Herz, Thomas Deller, Michael Frotscher, and Eckart Förster
Malformation of the Radial Glial Scaffold in the Dentate Gyrus of Reeler Mice, Scrambler Mice, and ApoER2/VLDLR-Deficient Mice
Journal of Comparative Neurology 460, 56–65 (2003)

Olav M. Andersen, Ching-Hey Yeung, Henrik Vorum, Maren Wellner, Thomas K. Andreassen, Bettina Erdmann, Eva-Christina Mueller, Joachim Herz, Albrecht Otto, Trevor G. Cooper, and Thomas E. Willnow
Essential role of the apolipoprotein E receptor-2 in sperm development.
J. Biol. Chem. 278, 23989-95 (2003)

Peggy C. Stolt, Hyesung Jeon, Hyun Kyu Song, Joachim Herz, Michael J. Eck, and Stephen C. Blacklow
Origins of Peptide Selectivity and Phosphoinositide Binding Revealed by Structures of Disabled-1 PTB Domain Complexes.
Structure 11, 569-79 (2003)

Petra May and Joachim Herz
LDL Receptor-Related Proteins in Neurodevelopment.
Traffic 4, 291-301 (2003)

Christopher Jones, Robert E. Hammer, Wei-Ping Li, Jonathan C. Cohen, Helen H. Hobbs, and Joachim Herz
Normal Sorting, But Defective Endocytosis of the LDL Receptor in Mice with Autosomal Recessive Hypercholesterolemia.
J. Biol. Chem. 278, 29024-29030 (2003)

Petra May, Hans H. Bock, Johannes Nimpf, and Joachim Herz
Differential Glycosylation Regulates Processing of Lipoprotein Receptors by gamma-Secretase.
J. Biol. Chem. 278, 37386–37392 (2003)

Eva Hartfuss, Eckart Förster, Hans H. Bock, Michael A. Hack, Pierre Leprince, Juan M. Luque, Joachim Herz, Michael Frotscher, and Magdalena Götz
Reelin signaling directly affects radial glia morphology and biochemical maturation.
Development 130, 4597-4609 (2003)

Hans H. Bock, Yves Jossin, Pingsheng Liu, Eckart Förster, Petra May, André M. Goffinet, and Joachim Herz
PI3-Kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination.
J. Biol. Chem. 278, 38772–38779 (2003)

Amir H. Assadi, Guangcheng Zhang, Uwe Beffert, Robert S. McNeil, Amy L. Renfro, Sanyong Niu, Carlo C. Quattrocchi, Barbara A. Antalffy, Michael Sheldon, Dawna D. Armstrong, Anthony Wynshaw-Boris, Joachim Herz, Gabriella D’Arcangelo, and Gary D. Clark
Interaction of reelin signaling and Lis1 in brain development.
Nature Genetics 35, 270-276 (2003)

Joachim Herz

LRP: a bright beacon at the blood-brain-barrier
J. Clin. Invest. 112, 1483-1485 (2003)

Uwe Beffert, Peggy C. Stolt, and Joachim Herz
Functions of lipoprotein receptors in neurons
Journal of Lipid Research 45, 403–409 (2004)

Marcel Vergés, Andre Bensadoun, Joachim Herz, John D. Belcher and Richard J. Havel
Endocytosis of hepatic lipase and lipoprotein lipase into rat liver hepatocytes in vivo is mediated by the low density lipoprotein receptor-related protein.
J. Biol. Chem. 279, 9030-9036 (2004)

Vera Strasser, Daniela Fasching, Christoph Hauser, Harald Mayer, Hans H. Bock, Thomas Hiesberger, Joachim Herz, Edwin J. Weeber, J. David Sweatt, Albéna Pramatarova, Brian Howell, Wolfgang J. Schneider, and Johannes Nimpf
Receptor Clustering is involved in Reelin signaling.
Mol. Cell. Biol. 24, 1378-1386 (2004)

Yves Jossin, Nina Ignatova, Thomas Hiesberger, Joachim Herz, Catherine Lambert de Rouvroit, and André M. Goffinet
The central fragment of Reelin, generated by proteolytic processing in vivo, is critical to its function during cortical plate development.
J. Neuroscience 24, 514 –521 (2004)

Sonia M. S. Espirito Santo, Nuno M. M. Pires, Gery Gerritsen, Niels Bovenschen, Ko Willems van Dijk, Hans M. G. Princen, André Bensadoun, Joachim Herz, Louis M. Havekes, and Bart J. M. van Vlijmen
Hepatic LDL Receptor-related Protein Deficiency in Mice Increases Atherosclerosis Independent of Plasma Cholesterol.
Blood 103, 3777-3782 (2004)

Uwe Beffert, Edwin Weeber, Gerardo Morfini, Jane Ko, Scott T. Brady, Li-Huei Tsai, J. David Sweatt, and Joachim Herz
Reelin and Cdk5 dependent signals cooperate in regulating neuronal migration and synaptic transmission.
J. Neuroscience 24, 1897-1906 (2004)

Joachim Herz and David Y. Hui
Lipoprotein Receptors in the Vascular Wall.
Current Opinion in Lipidology 15, 175-181 (2004)

Peter Marschang, Jochen Brich, Edwin J. Weeber, J. David Sweatt, John M. Shelton, James A. Richardson, Robert E. Hammer, and Joachim Herz
Normal Development and Fertility of Knockout Mice Lacking the Tumor Suppressor Gene LRP1b Suggest Functional Compensation by LRP1.
Mol. Cell. Biol. 24, 3782–3793 (2004)

Hans H. Bock, Yves Jossin, Petra May, Oliver Bergner, and Joachim Herz
Apolipoprotein E receptors are required for Reelin-induced proteasomal degradation of the neuronal adaptor protein Disabled-1.
J. Biol. Chem. 279, 33471-33479 (2004)

John D. Minna, Adi F. Gazdar, Stephen R. Sprang, Joachim Herz
A Bull’s Eye for Targeted Lung Cancer Therapy
Science 304, 1458-1461 (2004)

Petra May, Astrid Rohlmann, Hans H. Bock, Kai Zurhove, Jamey D. Marth, Eike D. Schomburg, Jeffrey L. Noebels, Uwe Beffert, J. David Sweatt, Edwin J. Weeber, and Joachim Herz
Neuronal LRP1 Functionally Associates with Postsynaptic Proteins Is Required for Normal Motor Function in Mice.
Mol. Cell. Biol. 24, 8872-8883 (2004)

Adi F. Gazdar, Hisayuki Shigematsu, Joachim Herz, and John D. Minna
Mutations and addiction to EGFR: the Achilles ‘heal’ of lung cancers?
Trends in Molecular Medicine 10, 481-486 (2004)

Caroline Petit-Turcotte, Nicole Aumont, Uwe Beffert, Doris Dea, Joachim Herz, Judes Poirier
The apoE receptor apoER2 is involved in the maintenance of efficient synaptic plasticity.
Neurobiology of Aging 26, 195–206 (2005)

Peggy C. Stolt, Ying Chen, Pingsheng Liu, Hans H. Bock, Stephen C. Blacklow, and Joachim Herz
Phosphoinositide binding by the Disabled-1 PTB domain is necessary for membrane localization and Reelin signal transduction.
J. Biol. Chem. 280, 9671-9677 (2005)

Aparna R. Aiyera, Narimon Honarpour, Joachim Herz, Deepak Srivastava
Loss of Apaf-1 leads to partial rescue of the HAND2-null phenotype.
Dev. Biol. 278, 155-162 (2005)

Hisayuki Shigematsu, Li Lin, Takao Takahashi, Masaharu Nomura, Makoto Suzuki, Ignacio I. Wistuba, Kwun M. Fong, Huei Lee, Shinichi Toyooka, Nobuyoshi Shimizu, Takehiko Fujisawa, Ziding Feng, Jack A. Roth, Joachim Herz, John D. Minna, Adi F. Gazdar
Clinical and Biological Features Associated With Epidermal Growth Factor Receptor Gene Mutations in Lung Cancers.
J. Natl. Cancer Inst. 97,  339-346  (2005)

Yoshiharu Takayama, Petra May, Richard G. W. Anderson, and Joachim Herz
Low-density lipoprotein receptor-related protein 1 (LRP1) controls endocytosis and c-Cbl-mediated ubiquitination of the platelet-derived growth factor receptor β (PDGFRβ).
J. Biol. Chem. 280, 18504-18510  (2005)

Uwe Beffert, Edwin J. Weeber, Andre Durudas, Shenfeng Qiu, Irene Masiulis, J. David Sweatt, Wei-Ping Li, Giselind Adelmann, Michael Frotscher, Robert E. Hammer, and Joachim Herz
Modulation of Synaptic Plasticity and Memory by Reelin Involves Differential Splicing of the Lipoprotein Receptor Apoer2.
Neuron 47, 567-579 (2005)   Alzforum Commentary   Neuron Preview  

Ying Chen, Uwe Beffert, Mert Ertunc, Tie-Shan Tang, Ege T. Kavalali, Ilya Bezprozvanny, Joachim Herz
Reelin Modulates NMDA Receptor Activity in Cortical Neurons.
J. Neuroscience 25, 8209–8216 (2005)

Hiroshi Kurosu, Masaya Yamamoto, Jeremy D. Clark, Johanne V. Pastor, Animesh Nandi, Prem Gurnani, Owen P. McGuinness, Hirotaka Chikuda, Masayuki Yamaguchi, Hiroshi Kawaguchi, Iichiro Shimomura, Yoshiharu Takayama, Joachim Herz, C. Ronald Kahn, Kevin P. Rosenblatt, and Makoto Kuro-o
Suppression of Aging in Mice by the Hormone Klotho.
Science 309, 1829-1833 (2005)

Petra May, Joachim Herz, Hans H. Bock
Molecular mechanisms of lipoprotein receptor signalling.
Cell Mol Life Sci. 62, 2325-2338 (2005)

Rita Garuti, Christopher Jones, Wei-Ping Li, Peter Michaely, Joachim Herz, Robert D. Gerard, Jonathan C. Cohen, Helen H. Hobbs
The modular adaptor protein ARH promotes LDLR clustering into clathrin-coated pits.
J. Biol. Chem.
280, 40996-1004 (2005)

Eric B. Johnson, Robert E. Hammer, and Joachim Herz
Abnormal development of the apical ectodermal ridge and polysyndactyly in MEGF7 deficient mice.
Hum. Mol. Gen. 14, 3523-3538 (2005)

Suzanne Guénette, Yang Chang, Thomas Hiesberger, James A. Richardson, Christopher B. Eckman, Elizabeth A. Eckman, Robert E. Hammer and Joachim Herz
Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development.
EMBO J. 25, 420-431 (2006)

Uwe Beffert, Andre Durudas, Edwin J. Weeber, Peggy C. Stolt, Klaus M. Giehl, J. David Sweatt, Robert E. Hammer, and Joachim Herz
Functional Dissection of Reelin Signaling by Site-Directed Disruption of Disabled-1 Adaptor Binding to Apolipoprotein E Receptor 2: Distinct Roles in Development and Synaptic Plasticity.
J. Neuroscience 26, 2041–2052 (2006)

Chunzhang Cao, Daniel A. Lawrence, Yang Li, Christine A.F. Von Arnim, Joachim Herz, Enming J. Su, Alexandra Makarova, Bradley T. Hyman, Dudley K. Strickland, and Li Zhang
Endocytic receptor LRP together with tPA and PAI-I coordinates Mac-1-dependent macrophage migration.
EMBO J. 25, 1860-1870 (2006)

Xiaobiao Li, Joachim Herz, and Denis Monard
Activation of ERK signaling upon alternative protease nexin-1 internalization mediated by syndecan-1.
J. Cellular Biochemistry 99, 936-951 (2006)

Eric B. Johnson, David J. Steffen, Kristen W. Lynch, and Joachim Herz
Defective Splicing of Megf7/Lrp4, a Regulator of Distal Limb Development, in Autosomal Recessive Mulefoot Disease
Genomics 88, 600-609 (2006)

Joachim Herz
The Switch on the RAPper's Necklace...
Molecular Cell 23, 451-455 (2006)

Hu L., Boesten L.S., May P., Herz J., Bovenschen N., Huisman M.V., Berbee J.F., Havekes L.M., van Vlijmen B.J., Tamsma J.T.
Macrophage Low-Density Lipoprotein Receptor-Related Protein Deficiency Enhances Atherosclerosis in ApoE/LDLR Double Knockout Mice
Arterioscler Thromb Vasc Biol. 26, 2710-2715 (2006)

Joachim Herz and Ying Chen
Reelin, lipoprotein receptors and synaptic plasticity
Nature Reviews Neuroscience 7, 850-859 (2006)

Uwe Beffert, Farnas Nematollah-Farsian, Irene Masiulis, Robert Hammer, Sung Ok Yoon, Klaus M. Giehl, and Joachim Herz
ApoE receptor 2 controls neuronal survival the adult brain
Current Biology 16, 2446-2452 (2006)                                       commentary

Christopher Jones, Rita Garuti, Peter Michaely, Wei-Ping Li, Nobuyo Maeda, Jonathan C. Cohen, Joachim Herz, and Helen H. Hobbs
Preservation of VLDL remnant clearance attenuates the phenotype of autosomal recessive hypercholesterolemia
J. Clin. Invest. 117, 165-174 (2007)

Joachim Herz
Overview: The Long and Winding Road to Understanding Alzheimer’s Disease.
Neuron 53, 477 - 479 (2007)

Guangcheng Zhang, Amir H. Assadi, Robert S. McNeil, Uwe Beffert, Anthony Wynshaw-Boris, Joachim Herz, Gary D. Clark, Gabriella D’Arcangelo
The Pafah1b Complex Interacts with the Reelin Receptor VLDLR.
PLoS ONE 2, e252, 1-9 (2007)     comments and citations

Philippe Boucher, Wei-Ping Li, Rachel L. Matz, Yoshiharu Takayama, Johan Auwerx, Richard G.W. Anderson, Joachim Herz
LRP1 Functions as an Atheroprotective Integrator of TGFβ and PDFG Signals in the Vascular Wall: Implications for Marfan Syndrome
PLoS ONE 2, e448, 1-7 (2007)     comments and citations

Susanna M. Hofmann, Li Zhou, Diego Perez-Tilve, Todd Greer, Erin Grant, Lauren Wancata, Andrew Thomas, Paul T. Pfluger, Joshua E. Basford, Dean Gilham, Joachim Herz, Matthias H. Tschöp, and David Y. Hui
Adipocyte LDL receptor related protein-1 expression modulates postprandial lipid transport, glucose homeostasis, and adiposity
J. Clin. Invest. 117, 3271-3282 (2007)

Qiang Liu, Celina V. Zerbinatti, Juan Zhang, Hyang-Sook Hoe, Baiping Wang, Sarah L. Cole, Joachim Herz, Louis Muglia, and Guojun Bu
Amyloid Precursor Protein Regulates Brain Apolipoprotein E and Cholesterol Metabolism through Lipoprotein Receptor LRP1
Neuron 56, 66-78 (2007)

Alin L. Akopians, Alex H. Babayan, Uwe Beffert, Joachim Herz, Allan I. Basbaum and Patricia E. Phelps
Contribution of the Reelin signaling pathways to nociceptive processing
Eur. J. Neuroscience 27, 523–537 (2008)

Matt Larouche, Uwe Beffert, Joachim Herz, and Richard Hawkes
The Reelin Receptors Apoer2 and Vldlr Coordinate the Patterning of Purkinje Cell Topography in the Developing Mouse Cerebellum
PLoS ONE 3, e1653, 1-14  (2008)    
comments and citations

Robert Lukowski, Pascal Weinmeister, Dominik Bernhard, Susanne Feil, Michael
Gotthardt, Joachim Herz, Steffen Massberg, Alma Zernecke, Christian Weber, Franz Hofmann and Robert Feil
Role of Smooth Muscle cGMP/cGKI Signaling in Murine Vascular Restenosis.
Arterioscler Thromb Vasc Biol. 28, 1244-1250  (2008)

Joachim Herz, Kym M. Boycott, Jillian S. Parboosingh

"Devolution" of bipedality.
Proc Natl Acad Sci U S A. 105, E25 (2008)

Kai Zurhove, Chikako Nakajima, Joachim Herz, Hans H. Bock, Petra May
γ-Secretase Limits the Inflammatory Response Through the Processing of LRP1.
Science Signaling 1, ra15, 1-12 (2008)
Science Signaling Podcast - Interview with Petra May

Atsushi Ohazama, Eric B. Johnson, Masato S. Ota, Hong J. Choi, Thantrira Porntaveetus, Shelly Oommen, Nobuyuki Itoh, Kazuhiro Eto, Amel Gritli- Linde, Joachim Herz, and Paul T. Sharpe
Lrp4 modulates extracellular integration of cell signaling pathways in development.
PLoS ONE 3, e4092, 1-11 (2008)     comments and citations

Joachim Herz, Ying Chen, Irene Masiulis, Li Zhou
Expanding Functions of Lipoprotein Receptors.
J. Lipid Res. 50, S287–S292 (2009)

Jérome Terrand, Véronique Bruban, Li Zhou, Wanfeng Gong, Zeina El Asmar, Petra May, Kai Zurhove, Philipp Hafner, Claude Philippe, Estelle Woldt, Rachel L. Matz, Céline Gracia, Daniel Metzger, Johan Auwerx, Joachim Herz, Philippe Boucher
LRP1 controls intracellular cholesterol storage and fatty acid synthesis through Wnt signaling.
J. Biol. Chem. 284, 381-388 (2009)

Irene Masiulis, Timothy A. Quill, Raymond F. Burk, and Joachim Herz
Differential functions of the Apoer2 intracellular domain in selenium uptake and cell signaling.
Biol. Chem. 390, 67-73 (2009)

Kym M Boycott, Carsten Bonnemann, Joachim Herz, Stephanie Neuert, Chandree Beaulieu, James N Scott, Anuradha Venkatasubramanian, Jillian S Parboosingh
Mutations in VLDLR as a Cause for Autosomal Recessive Cerebellar Ataxia with Mental Retardation (Dysequilibrium Syndrome)
J. Child Neurol.  24: 1310-1315 (2009)

Joachim Herz
ApoE receptors in the nervous system.
Current Opinion in Lipidology 20, 190-196 (2009)

Murat Durakoglugil, Ying Chen, Charles L. White, Ege T. Kavalali, and Joachim Herz
Reelin Signaling Antagonizes β-Amyloid at the Synapse.
Proc Natl Acad Sci USA 106, 15938–15943 (2009)        Alzforum commentary       Center Times

Li Zhou, Hong Y. Choi, Wi-Ping Li, Fang Xu, Joachim Herz
LRP1 Controls cPLA2 Phosphorylation, ABCA1 Expression and Cellular Cholesterol Export.
PLoS ONE 4, e6853, 1-9 (2009)    
comments and citations

Li Zhou, Yoshiharu Takayama, Philippe Boucher, Michelle D. Tallquist, Joachim Herz
LRP1 Regulates the Architecture of the Vascular Wall by Controlling PDGFRβ-Dependent Phosphatidylinositol 3-Kinase Activation.
PLoS ONE 4, e6922, 1-11 (2009)     comments and citations

Joshua E. Basford, Zachary W.Q. Moore, Li Zhou, Joachim Herz, David Y. Hui
Smooth Muscle LDL Receptor-related Protein-1 Inactivation Reduces Vascular Reactivity and Promotes Injury-induced Neointima Formation.
Arterioscl. Thromb. Vasc. Biol., 29, 1772-1778  (2009)

Mark P. Jedrychowski, Carlos A. Gartner, Steven P. Gygi, Li Zhou, Joachim Herz, Konstantin V. Kandror and Paul F. Pilch

Proteomic analysis of GLUT4 storage vesicles (GSVS) reveals low-density lipoprotein receptor-related protein 1 (LRP1) to be an important vesicle component and target of insulin signaling.
J Biol Chem. 285(1):104-114 (2010)  [Oct 28, 2009. [Epub ahead of print]]

Atsushi Ohazama, James Blackburn, Thantrira Porntaveetus, Masato Ota, Hong Choi, Eric Johnson, Philip Myers, Shelly Oommen, Kazuhiro Eto, John Kessler, Takashi Kondo, Gareth Fraser, J. Todd Streelman, Ulyses Pardiñas, Abigail Tucker, Pablo Ortiz, Cyril Charles, Laurent Viriot, Joachim Herz, Paul Sharpe
A role for suppressed incisor cuspal morphogenesis in the evolution of mammalian heterodont dentition.
Proc Natl Acad Sci USA 107, 92-97 (2010) [Epub 2009 Dec 14]

Hong Y. Choi, Marco Dieckmann, Joachim Herz, Andreas Niemeier
Lrp4, a Novel Receptor for Dickkopf 1 and Sclerostin, Is Expressed by Osteoblasts and Regulates Bone Growth and Turnover In Vivo.
PLoS ONE 4, e7930, 1-10 (2009)    
comments and citations

Chantelle F. Sephton, Shannon K. Good, Stan Atkin, Colleen M. Dewey, Paul Mayer, Joachim Herz, and Gang Yu
TDP-43 is a developmentally-regulated protein essential for early embryonic development.
J. Biol. Chem. 285, 6826-6834 (2010) [Epub 2009 Dec 29]

Martin F. Dietrich, Louise van der Weyden, Haydn M. Prosser, Allan Bradley, Joachim Herz (corresponding author), David J. Adams
Ectodomains of the LDL Receptor-related Proteins LRP1b and LRP4 Have Anchorage-Independent Functions in Vivo.
PLoS One 5, e9960, 1-7 (2010)         comments and citations

Courtney M. Karner, Martin F. Dietrich, Eric B. Johnson, Natalie Kappesser, Christian Tennert, Ferda Percin, Bernd Wollnik, Thomas J. Carroll, Joachim Herz
Lrp4 Regulates Initiation of Ureteric Budding and Is Crucial for Kidney Formation – A Mouse Model for Cenani-Lenz Syndrome.
PLoS One 5, e10418, 1-9  (2010)          comments and citations

Yun Li, Barbara Pawlik, Nursel Elcioglu, Mona Aglan, Hülya Kayserili, Gökhan Yigit, Ferda Percin, Frances Goodman, Gudrun Nürnberg, Asim Cenani, Jill Urquhart, Boi-Dinh Chung, Samira Ismail, Khalda Amr, Ayca D. Aslanger, Christian Becker, Christian Netzer, Pete Scambler, Wafaa Eyaid, Hanan Hamamy, Jill Clayton-Smith, Raoul Hennekam, Peter Nürnberg, Joachim Herz, Samia A. Temtamy, and Bernd Wollnik
LRP4 Mutations Alter Wnt/ß-Catenin Signaling and Cause Limb and Kidney Malformations in Cenani-Lenz Syndrome.
The American Journal of Human Genetics 86, 696-706 (2010)  [Epub 2010 Apr 8]

Eckart Förster, Hans H. Bock, Joachim Herz, Xuejun Chai, Michael Frotscher, and Shanting Zhao
Emerging topics in Reelin function.
European Journal of Neuroscience 31, 1511–1518 (2010)

Ying Chen, Murat Durakoglugil, Xunde Xian, and Joachim Herz
ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling.
Proc Natl Acad Sci USA 107, 12011-12016  [Epub 2010 Jun 14]
  (2010)        Alzforum commentary         Center Times         AHAF
Bianka Brunne, Shanting Zhao, Amin Derouiche, Joachim Herz, Petra May, Michael Frotscher, Hans H. Bock
Origin, maturation, and astroglial transformation of secondary radial glial cells in the developing dentate gyrus.
Glia 58(13):1553-69 (2010) Jun 14. [Epub ahead of print]

Marco Dieckmann, Martin F. Dietrich, Joachim Herz
Lipoprotein receptors--an evolutionarily ancient multifunctional receptor family.
Biological Chemistry 391(11):1341-63 (2010)

Jost Leemhuis, Elisabeth Bouche, Michael Frotscher, Frank Henle, Lutz Hein, Joachim Herz, Dieter K. Meyer, Marina Pichler, Günter Roth, Carsten Schwan, and Hans H. Bock
Reelin signals through apolipoprotein E receptor 2 and Cdc42 to increase growth cone motility and filopodia formation.
J. Neuroscience 30,14759-72 (2010)

Atsushi Ohazama, Thantrira Porntaveetus, Masato S. Ota, Joachim Herz, Paul T. Sharpe
Lrp4: A novel modulator of extracellular signaling in craniofacial organogenesis.
Am. J. Medical Genetics Part A 152A, 2974–2983 (2010)

Chantelle F. Sephton, Can Cenik, Alper Kucukural, Eric B. Dammer, Basar Cenik, YuHong Han, Colleen M. Dewey, Fritz P. Roth, Joachim Herz, Junmin Peng, Melissa J. Moore, Gang Yu
Identification of neuronal RNA targets of TDP-43-containing Ribonucleoprotein complexes.
J. Biol. Chem. 286(2):1204-1215 (2011)  [Epub
2010 Nov 4]

Philippe Boucher and Joachim Herz
Signaling through LRP1: Protection from atherosclerosis and beyond.
Biochem Pharmacol. 81(1):1-5 (2011) [Epub 2010 Oct 30]

Sangeetha Ramesh, Craig N. Morrell, Cristina Tarango, Gail D. Thomas, Ivan S. Yuhanna, Guillermina Girardi, Joachim Herz, Rolf T. Urbanus, Philip G. de Groot, Philip E. Thorpe, Jane E. Salmon, Philip W. Shaul, Chieko Mineo
Antiphospholipid antibodies promote leukocyte–endothelial cell adhesion and thrombosis in mice by antagonizing eNOS via β2GPI and apoER2.
J. Clin. Investigation 121(1):120-131 (2011) [Epub 2010 Dec 1]

Colleen M. Dewey, Basar Cenik, Chantelle F. Sephton, Daniel R. Dries, Paul Mayer III, Shannon K. Good, Brett A. Johnson, Joachim Herz, and Gang Yu
TDP-43 is directed to stress granules by sorbitol, a novel physiological osmotic and oxidative stressor.
Mol. Cell. Biol. 31(5):1098-108
(2011) [Epub 2010 Dec 20]

Qiang Liu, Juan Zhang, Celina Zerbinatti, Yan Zhan, Benedict J. Kolber, Joachim Herz, Louis J. Muglia, Guojun Bu
Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system.
PLoS Biol. 9(1):e1000575 (2011)

Huan Long, Hans H. Bock, Ting Lei, Xuejun Chai, Jihong Yuan, Joachim Herz, Michael Frotscher, Zaiqing Yang

Identification of alternatively spliced Dab1 and Fyn isoforms in pig.
BMC Neurosci. 12, 17 (14p)  (2011)

Daniel Baitsch, Hans H. Bock, Thomas Engel, Ralph Telgmann, Carsten Müller-Tidow, Georg Varga, Martine Bot, Joachim Herz, Horst Robenek, Arnold von Eckardstein, Jerzy-Roch Nofer
Apolipoprotein E Induces Antiinflammatory Phenotype in Macrophages.
Arterioscler Thromb Vasc Biol. 31, 1160-1168 (2011)

Fnu Nagajyothi, Louis M. Weiss, David L. Silver, Mahalia S. Desruisseaux, Philipp E. Scherer, Joachim Herz, Herbert B. Tanowitz
Trypanosoma cruzi Utilizes the Host Low Density Lipoprotein Receptor in Invasion.
PLoS Negl Trop Dis. 5(2):e953 (2011)

Haas J, Beer AG, Widschwendter P, Oberdanner J, Salzmann K, Sarg B, Lindner H, Herz J, Patsch JR, Marschang P.
LRP1b shows restricted expression in human tissues and binds to several extracellular ligands, including fibrinogen and apoE - carrying lipoproteins.
Atherosclerosis 216, 342-347 (2011)

Estelle Woldt, Rachel L. Matz, Jérome Terrand, Mohamed Mlih, Céline Gracia, Sophie Foppolo, Sophie Martin, Veronique Bruban, Julie Ji, Emilie Velot, Joachim Herz, and Philippe Boucher
Differential signaling by adaptor molecules LRP1-SHCA regulates adipogenesis by the insulin-like growth factor-1 receptor.
J. Biol. Chem. 286, 16775-16782 (2011)

Basar Cenik, Chantelle F. Sephton, Colleen M. Dewey, Xunde Xian, Shuguang Wei, Kimberley Yu, Wenze Niu, Giovanni Coppola, Sarah E. Coughlin, Suzee E. Lee, Daniel R. Dries, Sandra Almeida, Daniel H. Geschwind, Fen-Biao Gao, Bruce L. Miller, Robert V. Farese, Jr., Bruce A. Posner, Gang Yu, and Joachim Herz
SAHA (VORINOSTAT) upregulates progranulin transcription: a rational therapeutic approach to frontotemporal dementia.
J. Biol. Chem. 286, 16101-16108 (2011)

Justin H. Trotter, Martin Klein, Umesh K. Jinwal, Jose F. Abisambra, Chad A. Dickey, Jeremy Tharkur, Irene Masiulis, Jindong Ding, Kirstin G. Locke, Catherine Bowes Rickman, David G. Birch, Edwin J. Weeber, and Joachim Herz
ApoER2 Function in the Establishment and Maintenance of Retinal Synaptic Connectivity.

J. Neuroscience 31, 14413–14423 (2011)

Porntaveetus T, Ohazama A, Choi HY, Herz J, Sharpe PT.
Wnt signaling in the murine diastema.

Eur J Orthod. 34, 518-24  (2012)

David M. Holtzman, Joachim Herz, and Goujun Bu
Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease.
In: The Biology of Alzheimer Disease, Cold Spring Harbor Laboratory Press, New York, 279-301
Cold Spring Harb Perspect Med. 2012 Mar;2(3):a006312 (2012)  PMID: 22393530

Daniel R. Dries, Gang Yu, and Joachim Herz
Extracting β-amyloid from Alzheimer’s disease.
Proc. Natl. Acad. Sci. 109, 3199-3200 (2012)

Colleen M. Dewey, Basar Cenik, Chantelle F. Sephton, Brett A. Johnson, Joachim Herz, Gang Yu
TDP-43 aggregation in neurodegeneration: are stress granules the key?
Brain Res. 1462, 16-25 (2012)

Chantelle F. Sephton, Basar Cenik, Bercin K. Cenik, Joachim Herz, Gang Yu
TDP-43 in central nervous system development and function: clues to TDP-43-associated neurodegeneration.
Biol Chem. 393, 589-94 (2012)

Basar Cenik, Chantelle F. Sephton, Bercin K. Cenik, Joachim Herz, Gang Yu
Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration.

J Biol Chem. 287, 32298-32306 (2012)

Yang Du, Marie Yang, Wei Wei, HoangDinh Huynh, Joachim Herz, Alan Saghatelian, and Yihong Wan
Macrophage VLDLR receptor Promotes PAFAH Secretion in Mother's Milk and Suppresses Systemic Inflammation in Nursing Neonates.
Nature Communications 3, #1008 (2012)

Katsutoshi Sekine, Takeshi Kawauchi, Ken-ichiro Kubo, Takao Honda, Joachim Herz, Mitsuharu Hattori, Tatsuo Kinashi, and Kazunori Nakajima
Reelin controls neuronal migration and positioning by promoting neuronal adhesion to extracellular matrix via the inside-out activation of integrin α5β1.
Neuron 76, 353-69 (2012)

Estelle Woldt, Jérome Terrand, Mohamed Mlih, Rachel Matz, Véronique Bruban, Fanny Coudane, Sophie Foppolo, Zeina El Asmar, Maria Eugenia Chollet, Ewa Ninio, Audrey Bednarczyk, Danièle Thiersé, Christine Schaeffer-Reiss, Alain Van Dorsselaer, Christian Boudier, Walter Wahli, Pierre Chambon, Daniel Metzger, Joachim Herz, and Philippe Boucher
PPARγ counteracts LRP1-induced vascular calcification by inhibiting a Wnt5a signaling pathway.
Nature Communications 3, #1077 (2012)

Marco Dieckmann, F. Timo Beil, Brigitte Mueller, Alexander Bartelt, Robert P. Marshall, Till Koehne, Michael Amling, Wolfgang Ruether, Jackie A. Cooper, Steve E. Humphries, Joachim Herz, and Andreas Niemeier
Human Apolipoprotein E Isoforms differentially affect Bone Mass and Turnover in vivo.
Journal of Bone and Mineral Research
28(2):236-45 (2013)

Anne-Sophie Carlo, Camilla Gustafsen, Guido Mastrobuoni, Morten S. Nielsen, Tilman Burgert, Daniela Hartl, Michael Rohe, Anders Nykjaer, Joachim Herz, Joerg Heeren, Stefan Kempa, Claus Munck Petersen, and Thomas E. Willnow

The pro-neurotrophin receptor sortilin is a major neuronal apolipoprotein E receptor for catabolism of amyloid-β peptide in the brain.
J Neurosci. 33(1):358-70 (2013)

Elisabeth Bouché, Mario I. Romero-Ortega, Mark Henkemeyer, Timothy Catchpole, Jost Leemhuis, Michael Frotscher, Petra May, Joachim Herz, Hans H. Bock

Reelin induces EphB activation.
Cell Res. 23(4):473-90 (2013)

Andrew D. Nguyen, Thi A. Nguyen, Basar Cenik, Gang Yu, Joachim Herz, Tobias C. Walther, W. Sean Davidson, and Robert V. Farese, Jr.
Secreted progranulin is a homodimer and is not a component of high density lipoproteins (HDL).
J Biol Chem. 288(12):8627-35 (2013)

Xi Chen, Jianjun Chang, Qiudong Deng, Jie Xu, Thi A. Nguyen, Lauren H. Martens, Basar Cenik, Georgia Taylor, Kathryn F. Hudson, Jaegwon Chung, Kimberley Yu, Phillip Yu, Joachim Herz, Robert V. Farese Jr., Thomas Kukar, and Malu´ G. Tansey
Progranulin Does Not Bind Tumor Necrosis Factor (TNF) Receptors and Is Not a Direct Regulator of TNF-Dependent Signaling or Bioactivity in Immune or Neuronal Cells.
J Neurosci
. 33(21):9202-9213 (2013)

Chikako Nakajima, Akos Kulik, Michael Frotscher, Joachim Herz, Michael Schäfer, Hans H. Bock, Petra May
LDL receptor-related protein 1 (LRP1) modulates N-methyl-D-aspartate (NMDA) receptor-dependent intracellular signaling and NMDA-induced regulation of postsynaptic protein complexes.
J Biol Chem
. 288(30):21909-23 (2013) Jun 11. [Epub ahead of print]

Pohlkamp T, Dávid C, Cauli B, Gallopin T, Bouché E, Karagiannis A, May P, Herz J, Frotscher M, Staiger JF, Bock HH.
Characterization and Distribution of Reelin-Positive Interneuron Subtypes in the Rat Barrel Cortex.
Cereb Cortex. 2013 Jun 26. [Epub ahead of print]

Brunne B, Franco S, Bouché E, Herz J, Howell BW, Pahle J, Müller U, May P, Frotscher M, Bock HH.
Role of the postnatal radial glial scaffold for the development of the dentate gyrus as revealed by Reelin signaling mutant mice.
61(8):1347-63 (2013) Epub  Jul 4.

Choi HY, Liu Y, Tennert C, Sugiura Y, Karakatsani A, Kröger S, Johnson EB, Hammer RE, Lin W, Herz J.
APP interacts with LRP4 and agrin to coordinate the development of the neuromuscular junction in mice.
Aug 20;2:e00220. doi: 10.7554/eLife.00220 (2013)

Bal M, Leitz J, Reese AL, Ramirez DM, Durakoglugil M, Herz J, Monteggia LM, Kavalali ET.
Reelin mobilizes a VAMP7-dependent synaptic vesicle pool and selectively augments spontaneous neurotransmission.
80(4):934-46 (2013) Epub 2013 Nov 7.

Gilat-Frenkel M, Boehm-Cagan A, Liraz O, Xian X, Herz J, Michaelson DM.
Involvement of the Apoer2 and Lrp1 receptors in mediating the pathological effects of ApoE4 in vivo.
Curr Alzheimer Res. 2014;11(6):549-57.

Subramanian M, Hayes CD, Thome JJ, Thorp E, Matsushima GK, Herz J, Farber DL, Liu K, Lakshmana M, Tabas I.
An AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo.
J. Clin. Invest
. 124(3):1296-308 (2014) Epub Feb 10.

Prabhudas M, Bowdish D, Drickamer K, Febbraio M, Herz J, Kobzik L, Krieger M, Loike J, Means TK, Moestrup SK, Post S, Sawamura T, Silverstein S, Wang XY, El Khoury J.
Standardizing scavenger receptor nomenclature.
J Immunol
. 192(5):1997-2006  (2014)

Schorch B, Song S, van Diemen FR, Bock HH, May P, Herz J, Brummelkamp TR, Papatheodorou P, Aktories K.
LRP1 is a receptor for Clostridium perfringens TpeL toxin indicating a two-receptor model of clostridial glycosylating toxins.
Proc Natl Acad Sci U S A
111(17):6431-6 (2014) Epub Apr 15.

Pohlkamp T, Steller L, May P, Günther T, Schüle R, Frotscher M, Herz J, Bock HH.
Generation and characterization of an Nse-CreERT2 transgenic line suitable for inducible gene manipulation in cerebellar granule cells.
PLoS One  9(6):e100384 (2014)

Lane-Donovan C, Herz J.
Is Apolipoprotein E Required for Cognitive Function in Humans?: Implications for Alzheimer Drug Development.
JAMA Neurol
. 2014 Aug 11. [Epub ahead of print]

Lane-Donovan C, Philips GT, Herz J.
More than Cholesterol Transporters: Lipoprotein Receptors in CNS Function and Neurodegeneration.
83(4):771-787  (2014)

Ward ME, Taubes A, Chen R, Miller BL, Sephton CF, Gelfand JM, Minami S, Boscardin J, Martens LH, Seeley WW, Yu G, Herz J, Filiano AJ, Arrant AE, Roberson ED, Kraft TW, Farese RV Jr, Green A, Gan L.
Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD.
J. Exp. Med. 211(10):1937-45 (2014) Epub Aug 25.

Ulrich V, Konaniah ES, Herz J, Gerard RD, Jung E, Yuhanna IS, Ahmed M, Hui DY, Mineo C, Shaul PW.
Genetic variants of ApoE and ApoER2 differentially modulate endothelial function.
Proc Natl Acad Sci U S A
111(37):13493-8 (2014)  Epub  Sep 2.

Sephton CF, Tang A, West J, Brooks M, Kulkarni A, Stubblefield J, Liu Y, Zhang MQ, Green CB, Huber KM, Huang EJ, Herz J, Yu G
Activity-Dependent FUS Dysregulation Disrupts Synaptic Homeostasis at Dendritic Spines.
Proc Natl Acad Sci USA
111(44):E4769-78 (2014)

Nakajima C, Haffner P, Goerke SM, Zurhove K, Adelmann G, Frotscher M, Herz J, Bock HH, May P.
The lipoprotein receptor LRP1 modulates sphingosine-1-phosphate signaling and is essential for vascular development.
Development 141(23):4513-25 (2014)

Wasser CR, Masiulis I, Durakoglugil MS, Lane-Donovan C, Xian X, Beffert U, Agarwala A, Hammer RE, Herz J.
Differential splicing and glycosylation of Apoer2 alters synaptic plasticity and fear learning.
Science Signaling  7(353):ra113 (2014)    Interview   Cover

Sharmistha Chakraborty, Li Li, Vineshkumar, Thidil Puliyaddadamba, Gao Guo, Kimmo J. Hatanpaa, Bruce Mickey, Rhonda F. Souza, Peggy Vo, Joachim Herz, Mei-Ru Chen, David A. Boothman, Tej K. Pandita, David H. Wang, Ganes C. Sen, and Amyn A. Habib
Constitutive and ligand-induced EGFR signaling trigger distinct and mutually exclusive downstream signaling networks.
Nat Commun. 5:5811 (2014)

Theresa Pohlkamp, Murat Durakoglugil, Courtney Lane-Donovan, Xunde Xian, Eric B Johnson, Joachim Herz
Lrp4 domains differentially regulate limb/brain development and synaptic plasticity.
PLoS One.10(2):e0116701 (2015).

Jaehong Suh, Juliet A. Moncaster, Lirong Wang, Imran Hafeez, Joachim Herz, Rudolph E. Tanzi, Lee E. Goldstein, and Suzanne Y. Guènette
FE65 and FE65L1 amyloid precursor protein-binding protein compound null mice display adult-onset cataract and muscle weakness.
FASEB J. 29, 000-000 (2015) Epub Mar 10.
Courtney Lane-Donovan, Gary T. Philips, Catherine R. Wasser, Murat S. Durakoglugil, Irene Masiulis, Ajeet Upadhaya, Theresa Pohlkamp, Cagil Coskun, Tiina Kotti, Laura Steller, Robert E. Hammer, Michael Frotscher, Hans H. Bock, Joachim Herz
Reelin protects against amyloid-beta toxicity in vivo.
Sci Signal. 8(384):ra67 (2015).

Suzanne Eldridge, Giovanna Nalesso , Habib Ismail, Karin Vicente-Greco, Panos Kabouridis, Manoj Ramachandran, Andreas Niemeier, Joachim Herz, Costantino Pitzalis, Mauro Perretti, Dell'Accio
Agrin mediates chondrocyte homeostasis and requires both LRP4 and alpha-dystroglycan to enhancecartilage formation in vitro and in vivo.
Ann Rheum Dis. 207316 (2015) Epub Feb. 19.  

Catherine Wasser and Joachim Herz
Splicing therapeutics for Alzheimer's disease.
EMBO Mol Med. e201506067 (2016).

Courtney Lane-Donovan and Joachim Herz
High-Fat Diet Changes Hippocampal Apolipoprotein E (ApoE) in a Genotype- and Carbohydrate-Dependent Manner in Mice.
PLoS One. 11(2):e0148099 (2016).

Zeina El Asmar, Jérome Terrand, Marion Jenty, Lionel Host, Mohamed Mlih, Aurélie Zerr,  Hélène Justiniano, Rachel L. Matz, Christian Boudier, Estelle Scholler, Jean-Marie Garnier, Diego Bertaccini, Danièle Thiersé, Christine Schaeffer, Alain Van Dorssselear, Joachim Herz, Véronique Bruban, Philippe Boucher
Convergent Signaling Pathways Controlled by LRP1 (LDL Receptor-related Protein 1) Cytoplasmic and Extracellular Domains Limit Cellular Cholesterol Accumulation.
J Biol Chem. 291(10):5116-27 (2016) Epub Jan 19.

Victoria Ulrich, Shari E. Gelber, Milena Vukelic, Anastasia Sacharidou, Joachim Herz, Rolf T. Urbanus, Philip G. de Groot, David R. Natale, Anirudha Harihara,  Patricia Redecha, Vikki M. Abrahams, Philip W. Shaul, Jane E. Salmon, Chieko Mineo
ApoE Receptor 2 Mediation of Trophoblast Dysfunction and Pregnancy Complications Induced by Antiphospholipid Antibodies in Mice.
Arthritis Rheumatol. 68(3):730-9 (2016).

Yinyuan Ding, Linzhang Huang, Xunde Xian, Ivan S. Yuhanna, Catherine R. Wasser, Michael Frotscher, Chieko Mineo, Philip W. Shaul, Joachim Herz
Loss of Reelin protects against atherosclerosis by reducing leukocyte-endothelial cell adhesion and lesion macrophage accumulation.
Sci. Signal. 9(419):ra29 (2016).

(updated March 30, 2016)