Publications
Selected Abstracts and Meetings Proceedings:
Eycke Boehme, Christiane Spies, Georg Grossmann, and Joachim Herz
Stimulation of Soluble Guanylate Cyclase by Sydnonimines: Relaxants
of Smooth Muscle and Inhibitors of Platelet Aggregation.
Naunyn-Schmiedebergs Arch. Pharmacol. 316: 26 (1981)
Joachim Herz, Ute Hamann and
Keith K. Stanley
A liver mRNA with high sequence homology to the LDL-receptor.
J. Cell Biol. 105, 236a (1987)
Joachim Herz, David
Clouthier, Michael S. Brown, Joseph L. Goldstein, and Robert E.
Hammer
The LDL Receptor Supergene Family.
Keystone Symposia, Supplement 16F, 37 (1992)
Joachim Herz, Robert C.
Kowal, Michael S. Brown, and Joseph L. Goldstein
Cellular uptake of lipoproteins through LRP is apo E-dependent
J. Drug Devel. 3 (suppl. 1), 71-76 (1990)
Joachim Herz
The Low Density Lipoprotein Receptor-related Protein: An Endocytic
Receptor with Dual Ligand Specificity.
in "Hepatic Endocytosis of Lipids and Proteins", E. Windler and H.
Greten, eds., Zuckschwerdt Verlag, pp. 46 - 52 (1992)
Book Contributions:
Thomas E. Willnow and Joachim Herz
Homologous
Recombination
for Gene Replacement in Mouse Cell Lines.
In: Methods in Cell Biology 43: Protein Expression in Animal
Cells. M. Roth, ed., Academic Press, San
Diego, Vol. 43, 305-334 (1994)
Thomas E. Willnow, Shun Ishibashi and Joachim Herz
Genetic Manipulation of Lipoprotein Receptors: Implications
for Lipid Metabolism and Atherosclerosis.
In: Cardiovascular Disease '94: Cellular and Molecular Mechanisms,
Prevention, Treatment. L. Gallo, ed., Plenum Press, New York,
307-312 (1995)
Thomas E. Willnow and Joachim Herz
Gene Inactivation by Homologous Recombination - Animal Models of
Plasma Lipoprotein Disorders
Chapter 8, In: Concepts in Gene Therapy. Michael Strauss and
John Barranger, eds., Walter de Gruyter Berlin, New York, 123-140
(1997)
Joachim Herz
Physiology of the LDL Receptor-Related Protein: Functions in
ApoE-Mediated Remnant Metabolism and Other Biological Processes
in "Lipoproteins in Health and Disease"; Betteridge, Illingworth,
and Shepherd, eds., Edward and Arnold, London; Chapter 18, pp.
333-359 (1999)
Joachim Herz, Uwe Beffert,
Thomas Hiesberger, Michael Gotthardt
ApoE Receptors in the Brain: Novel Signaling Pathways with
Potential Relevance for Alzheimer’s Disease
In “Research and Perspectives in Alzheimer’s Disease”; Beyreuther,
Christensen, Masters, eds.; Springer Verlag, Berlin,
Heidelberg, Hong Kong, London, Milan, Paris, Tokyo (2001)
Joachim Herz
Lipoprotein Receptors.
Encyclopedia of Molecular Medicine, T. Creighton, ed., John Wiley
and Sons
Hans H. Bock, Petra May, Joachim
Herz
Lipoprotein
Transport.
In "Transgenic Models in Pharmacology"; Stefan Offermanns, Lutz
Hein, eds.; Springer Verlag, Berlin, Heidelberg, Hong Kong, London,
Milan, Paris, Tokyo; Part 4. Cardiovascular System, pp. 397 - 421
(2003)
Hans H. Bock, Joachim Herz,
Petra May
Conditional
AnimalModels
for the Study of LipidMetabolism and Lipid Disorders.
HEP178, 403–435 (2007) - Springer-Verlag Berlin Heidelberg
Hans H. Bock and Joachim Herz
Apolipoprotein E receptor 2 and very low density lipoprotein
receptor: An overview.
In Fatemi, S.H. (ed), Reelin Glycoprotein, Structure, Biology and
Roles in Health and Disease. Springer, New York, pp. 15-35
(2008)
Peer Reviewed Articles:
Eycke Boehme, Rupert Gerzer, Gerd Grossmann, Joachim Herz, Alexander Mülsch,
Cornelie Spies, and Günter Schultz.
Regulation of Soluble Guanylate Cyclase Activity.
Hormones and Cell Regulation 7, 147-161, (1983)
Eycke Boehme, Georg Grossmann, Joachim
Herz, Alexander Muelsch, Christiane Spiess, and Günter
Schultz
Regulation of cyclic GMP formation by soluble guanylate cyclase:
stimulation by NO-containing compounds.
Adv. Cyclic Nucleotide Protein Phosphorylation Res. 17:
259-266 (1984)
Harald Haymerle, Joachim Herz,
Giorgio M. Bressan, Rainer Frank, and Keith K. Stanley
Efficient
construction
of cDNA libraries in plasmid expression vectors using an adaptor
strategy.
Nucleic Acids Res. 14, 8615-8624 (1986)
Keith K. Stanley and Joachim Herz
Topological
mapping
of complement component C9 by recombinant DNA techniques suggests
a novel mechanism for its insertion into target membranes.
EMBO J. 6, 1951-1957 (1987)
Dieter Jenne, Claudine Rey, Daniele Masson, Keith K. Stanley, Joachim Herz, Geert Plaetinck,
and Jürg Tschopp
cDNA cloning of granzyme C, a granule-associated serine
protease of cytolytic T lymphocytes.
J. Immunol. 140, 318-323 (1988)
D. Koesling, J. Herz, H.
Gausepohl, F. Niroomand, K.-D. Hinsch, A. Mülsch, E. Böhme, G.
Schultz, and R. Frank
The primary structure of the 70 kDa subunit of bovine soluble
guanylate cyclase.
FEBS letters 239 (1): 29-34 (1988)
Joachim Herz, Ute Hamann,
Sissel Rogne, Ola Myklebost, Heinrich Gausepohl, and Keith K.
Stanley
Surface
location
and high affinity for calcium of a 500 kd liver membrane protein
closely related to the LDL receptor suggest a physiological role
as lipoprotein receptor.
EMBO J. 7, 4119-4127 (1988)
Ola Myklebost, Kristina Arheden, Sissel Rogne, Ad Geurts van Kessel,
Nils Mandahl, Joachim Herz,
Keith Stanley, Sverre Heim, and Felix Mitelman
The Gene for the Human Putative apoE Receptor is on Chromosome 12 in
the Segment q13-14.
Genomics 5, 65-69 (1989)
Ulrike Beisiegel, Wilfried Weber, Gudrun Ihrke, Joachim Herz, and Keith K.
Stanley
The
LDL
receptor-related protein, LRP, is an apolipoprotein E-binding
protein.
Nature 341, 162-164 (1989)
Robert C. Kowal, Joachim Herz,
Joseph L. Goldstein, Victoria Esser, and Michael S. Brown
Low
density
lipoprotein receptor-related protein mediates uptake of
cholesteryl esters derived from apo E-enriched lipoproteins.
Proc. Natl. Acad. Sci. 86, 5810-5814 (1989)
Karin Roemisch, Jane Webb, Joachim
Herz, Siegfried Prehn, Rainer Frank, Martin Vingron, and
Bernhard Dobberstein
Homology
of
54K protein of signal-recognition particle, docking protein and
two E.coli proteins with putative GTP-binding domains.
Nature 340, 478-482 (1989)
Heike Kuett, Joachim Herz,
and Keith K. Stanley
Structure
of
the low density lipoprotein receptor-related protein (LRP)
promoter.
Biochem. Biophys. Acta 1009 (3): 229-236 (1989)
Siegfried Prehn, Joachim Herz,
Enno Hartmann, Teymuras V. Kurzchalia, Rainer Frank, Karin Roemisch,
Bernhard Dobberstein, and Tom A. Rapoport
Structure and Biosynthesis of the Signal Sequence Receptor.
Eur. J. Biochem. 188, 439-445 (1990)
Joachim Herz, Robert C.
Kowal, Joseph L. Goldstein, and Michael S. Brown
Proteolytic
processing
of the 600 kd low density lipoprotein receptor-related protein
(LRP) occurs in a trans-Golgi compartment.
EMBO J. 9, 1769-1776 (1990)
Robert C. Kowal, Joachim Herz,
Karl H. Weisgraber, Robert W. Mahley, Michael S. Brown, and Joseph
L. Goldstein
Opposing effects of Apolipoproteins E and C on Lipoprotein Binding
to Low Density Lipoprotein Receptor-related Protein.
J. Biol. Chem. 265, 10771-10779 (1990)
Joachim Herz, Robert C.
Kowal, Y.K. Ho, Michael S. Brown, and Joseph L. Goldstein
Low density lipoprotein receptor-related protein (LRP) mediates
endocytosis of monoclonal antibodies in cultured cells and rabbit
liver.
J. Biol. Chem. 265, 21355-21362 (1990)
Karl H. Weisgraber, Robert W. Mahley, Robert C. Kowal, Joachim Herz, Joseph L.
Goldstein, and Michael S. Brown
Apolipoprotein C-I Modulates the Interaction of Apolipoprotein E
with ß-Migrating Very Low Density Lipoproteins (ß-VLDL) and
Inhibits Binding of ß-VLDL to Low Density Lipoprotein
Receptor-related Protein.
J. Biol. Chem. 265, 22453-22459 (1990)
Joachim Herz, Nicholas
Flint, Keith K. Stanley, Rainer Frank, and Bernhard Dobberstein
The 68 kDa protein of signal recognition particle contains a
glycine-rich region also found in certain RNA-binding proteins.
FEBS letters 276 (1,2), 103-107 (1990)
Dirk Goerlich, Siegfried Prehn, Enno Hartmann, Joachim Herz, Albrecht Otto,
Regine Kraft, Martin Wiedmann, Siegne Knespel, Bernhard Dobberstein,
and Tom A. Rapoport
The
Signal
Sequence Receptor Has a Second Subunit and Is Part of a
Translocation Complex in the Endoplasmic Reticulum as Probed by
Bifunctional Reagents.
J. Cell Biol. 111, 2283-2294 (1990)
Michael S. Brown, Joachim Herz,
Robert C. Kowal, and Joseph L. Goldstein
The low density lipoprotein receptor-related protein: double agent
or decoy?
Current Opinion in Lipidology 2, 65-72 (1991)
Joachim Herz, Joseph L.
Goldstein, Dudley K. Strickland, Y.K. Ho, and Michael S. Brown
39-kDa Protein Modulates Binding of Ligands to Low Density
Lipoprotein Receptor-related Protein/a2-Macroglobulin Receptor.
J. Biol. Chem. 266, 21232-21238 (1991)
Kim Orth, Edwin L. Madison, Mary-Jane Gething, Joseph F. Sambrook,
and Joachim Herz
Complexes of t-PA and its serpin inhibitor PAI-1 are
internalized via the LRP/a2-Macroglobulin Receptor.
Proc. Natl. Acad. Sci. 89, 7422-7426 (1992)
Sylvie Paulien, Avery A. Sandberg, Joachim
Herz, and Robert M. Gemmill
Putative Apolipoprotein Receptor Gene (LRP, a2MR) Is Not Rearranged
in Either Myxoid Liposarcoma or Lipomas with Translocations in
12q13-14.
Canc. Gen. Cytogen. 60, 125-130 (1992)
Joachim Herz, David E.
Clouthier, Robert E. Hammer
LDL
Receptor-Related
Protein Internalizes and Degrades uPA/PAI-1 Complexes and Is
Essential for Embryo Implantation.
Cell 71, 411 - 421 (1992) [Correction Cell 73, 428 (1993)]
Thomas E. Willnow, Joseph L. Goldstein, Kim Orth, Michael S. Brown,
and Joachim Herz
Low Density Lipoprotein Receptor-Related Protein (LRP) and gp330
Bind Similar Ligands, Including Plasminogen Activator/Inhibitor
Complexes and Lactoferrin, An Inhibitor of Chylomicron Remnant
Clearance.
J. Biol. Chem. 267, 26172 - 26180 (1992)
Olivier Descamps, David Bilheimer, and Joachim Herz
Insulin
Stimulates
Receptor-mediated Uptake of Apo E-enriched Lipoproteins and
Activated a2-Macroglobulin in Adipocytes.
J. Biol. Chem. 268, 974 - 981 (1993)
Joachim Herz and Robert D.
Gerard
Adenovirus-mediated Transfer of Low Density Lipoprotein Receptor
Gene Acutely Accelerates Cholesterol Clearance In Normal Mice
Proc. Natl. Acad. Sci. 90, 2812-2816 (1993)
Joachim Herz
The LDL Receptor-related Protein - Portrait of a Multifunctional
Receptor.
Current Opinion in Lipidology 4, 107-113 (1993)
Shun Ishibashi, Michael S. Brown, Joseph L. Goldstein, Robert D.
Gerard, Robert E. Hammer, and Joachim
Herz
Hypercholesterolemia
In
LDL Receptor Knockout Mice And Its Reversal By Adenovirus-Mediated
Gene Transfer.
J. Clin. Invest. 92, 883-893 (1993)
Thomas W. Rosahl, Martin Geppert, Diane Spillane, Joachim Herz, Robert E. Hammer,
Robert C. Malenka, and Thomas C. Südhof
Short-Term
Plasticity
Is Altered in Mice Lacking Synapsin I.
Cell 75, 661-670 (1993)
Monty Krieger and Joachim Herz
Structures
and
Functions of Multiligand Lipoprotein Receptors: Macrophage
Scavenger Receptors and LDL Receptor-Related Protein (LRP)
Ann. Rev. Biochem. 63, 601-637 (1994)
Joachim Herz and Thomas E.
Willnow
Functions of the LDL Receptor Gene Family.
Annals N.Y. Acad. Sci. 737, 14-19 (1994)
Thomas E. Willnow and Joachim Herz
Genetic Deficiency in Low Density Lipoprotein Receptor-related
Protein (LRP) Confers Cellular Resistance to Pseudomonas Exotoxin A
- Evidence that LRP Is Required for Uptake and Degradation of
Multiple Ligands.
J. Cell Science 107, 719-726 (1994)
Shun Ishibashi, Joseph L. Goldstein, Michael S. Brown, Joachim Herz, and Dennis K.
Burns
Massive Xanthomatosis and Atherosclerosis in Cholesterol-Fed LDL
Receptor-Negative Mice.
J. Clin. Invest. 93, 1885-1893 (1994)
Shun Ishibashi, Joachim Herz,
Nobuyo Maeda, Joseph L. Goldstein, and Michael S. Brown
The
two-receptor
model of lipoprotein clearance: Tests of the hypothesis in
knockout mice lacking the LDL receptor, apoE, and both proteins.
Proc. Natl. Acad. Sci. USA 91, 4431-4435 (1994)
Hiroshi Mokuno, Sandra Brady, Leila Kotite, Joachim Herz, and Richard J.
Havel
Effect of the 39-kDa Receptor-associated Protein on the Hepatic
Uptake and Endocytosis of Chylomicron Remnants and Low Density
Lipoproteins in the Rat.
J. Biol. Chem. 269, 13238-13243 (1994)
Thomas E. Willnow, Kim Orth, and Joachim
Herz
Molecular Dissection of Ligand Binding Sites on the LDL
Receptor-related Protein.
J. Biol. Chem. 269, 15827-15832 (1994)
Thomas E. Willnow, Zeqi Sheng, Shun Ishibashi, and Joachim Herz
Inhibition
of
Hepatic Chylomicron Remnant Uptake by Gene Transfer of A Receptor
Antagonist.
Science 264, 1471-1474 (1994)
Kim Orth, Thomas Willnow, Joachim
Herz, Mary-Jane Gething, and Joseph Sambrook
Low Density Lipoprotein Receptor-related Protein (LRP) Is
Necessary for the Internalization of Both Tissue-type Plasminogen
Activator-Inhibitor-1 (t-PA:PAI-1) Complexes and Free Tissue-type
Plasminogen Activator (t-PA).
J. Biol. Chem. 269, 21117-21122 (1994)
Shun Ishibashi, Robert E. Hammer, and Joachim Herz
Asialoglycoprotein Receptor-Deficiency in Mice Lacking the Minor
Receptor Subunit.
J. Biol. Chem. 269, 27803-27806 (1994)
Wolfgang Poller, Thomas E. Willnow, Jan Hilpert, and Joachim Herz
Differential Recognition of a1-Antitrypsin/Elastase and a1
-Antichymotrypsin/Cathepsin G - Complexes by the Low Density
Lipoprotein Receptor-related Protein.
J. Biol. Chem. 270, 2841-2845 (1995)
Joachim Herz and Thomas E.
Willnow
Lipoprotein and Receptor Interactions In Vivo.
Current Opinion in Lipidology 6, 97-103 (1995)
Yasunori Osono, Laura A. Woollett, Joachim
Herz, and John M. Dietschy
Role of the Low Density Lipoprotein Receptor in the Flux of
Cholesterol Through the Plasma and Across the Tissues of the Mouse.
J. Clin. Invest. 95, 1124-1132 (1995)
Thomas E. Willnow, Scott A. Armstrong, Robert E. Hammer, and Joachim Herz
Functional Expression of Low Density Lipoprotein (LDL)
Receptor-related Protein (LRP) Is Controlled By
Receptor-Associated Protein (RAP) In Vivo.
Proc. Natl. Acad. Sci. USA 92, 4537-4541 (1995)
Joachim Herz, Shi-Qiang Qiu,
Adair Oesterle, Harshini V. DeSilva, Shahida Shafi, and Richard J.
Havel
Initial hepatic removal of chylomicron remnants is unaffected but
endocytosis is delayed in mice lacking the low density lipoprotein
receptor.
Proc. Natl. Acad. Sci. USA 92, 4611-4615 (1995)
Joachim Herz
Erforschung der Ursachen und Behandlung der Atherosklerose:
Tiermodelle sind unverzichtbar.
Med-Report 8, 3 (1995)
Thomas W. Rosahl, Diane Spillane, Markus Missler, Joachim Herz, David K. Selig,
Joachim R. Wolff, Robert E. Hammer, Robert C. Malenka, and Thomas C.
Südhof
Essential functions of synapsin I and synapsin II in synaptic
vesicle regulation.
Nature 375, 488- 493 (1995)
Thomas E. Willnow and Joachim Herz
Animal models for disorders of hepatic lipoprotein metabolism.
J. Mol. Med. 73, 213-220 (1995)
Masaaki Narita, Guojun Bu, Joachim
Herz, and Alan L. Schwartz
Two Receptor Systems are Involved in the Plasma Clearance of
Tissue-type Plasminogen Activator (t-PA) In Vivo.
J. Clin. Invest. 96, 1164-1168 (1995)
Philip K. Frykman, Michael S. Brown, Tokuo Yamamoto, Joseph L.
Goldstein, and Joachim Herz
Normal plasma lipoproteins and fertility in gene-targeted mice
homozygous for a disruption in the gene encoding very low density
lipoprotein receptor.
Proc. Natl. Acad. Sci. USA 92, 8453-8457 (1995)
Masaaki Narita, Guojun Bu, Gillian M. Olins, Darryl A. Higuchi, Joachim Herz, George J. Broze,
Jr., and Alan L. Schwartz
Two Receptor Systems Are Involved in the Plasma Clearance of
Tissue Factor Pathway Inhibitor in Vivo.
J. Biol. Chem. 270, 24800-24804 (1995)
Laura A. Woollett, Yasunori Osono, Joachim
Herz, and John M. Dietschy
Apolipoprotein
E
competitively inhibits receptor-dependent low density lipoprotein
uptake by the liver but has no effect on cholesterol absorption or
sythesis in the mouse.
Proc. Natl. Acad. Sci. USA 92, 12500-1504 (1995)
Thomas E. Willnow, Joan M. Moehring, Noel M. Inocencio, Thomas J.
Moehring, and Joachim Herz
The
low
density lipoprotein receptor-related protein (LRP) is processed by
furin in vivo and in vitro.
Biochemical J. 313, 71-76 (1996)
Thomas E. Willnow, Astrid Rohlmann, Jay Horton, Hideo Otani, Jürgen
R. Braun, Robert E. Hammer and Joachim
Herz
RAP,
a
specialized chaperone, prevents ligand-induced ER-Retention and
degradation of LDL receptor-related endocytic receptors.
EMBO J. 15, 2632-2639 (1996)
E. Sehayek, X.X. Wang, I. Vlodavsky, R. Avner, H. Levkovitz, T.
Olivecrona, G. Olivecrona, T.E. Willnow, J. Herz, S. Eisenberg
Heparan Sulfate-Dependent and Low Density Lipoprotein
Receptor-Related Protein-Dependent Catabolic Pathways for
Lipoprotein Lipase in Mouse Embryonic Fibroblasts.
Israel Journal of Medical Sciences 32, 449-454 (1996)
Shun Ishibashi, Margrit Schwarz, Philip K. Frykman, Joachim Herz and David W.
Russell
Disruption
of
cholesterol 7a-hydroxylase gene in mice. I. Postnatal lethality
reversed by bile acid and vitamin supplementation.
J. Biol. Chem. 271, 18017-18023 (1996)
Margrit Schwarz, Erik G. Lund, Kenneth D. R. Setchell, Herbert J.
Kayden, J. E. Zerwekh, Ingemar Bjorkhem, Joachim Herz and David W. Russell
Disruption of cholesterol 7a-hydroxylase gene in mice. II. Bile
acid deficiency is overcome by induction of oxysterol
7a-hydroxylase.
J. Biol. Chem. 271, 18024-18031 (1996)
Thomas E. Willnow, Jan Hilpert, Scottt A. Armstrong, Astrid
Rohlmann, Robert E. Hammer, Dennis K. Burns and Joachim Herz
Defective
forebrain
development in mice lacking gp330/ megalin.
Proc. Natl. Acad. Sci. USA 93, 8460-8464 (1996)
Jürgen R. Braun, Thomas E. Willnow, Shun Ishibashi, Gilbert Ashwell,
and Joachim Herz
The Major Subunit of the Asialoglycoprotein Receptor is Expressed
on the Hepatocellular Surface in Mice Lacking the Minor Receptor
Subunit.
J. Biol. Chem. 271, 21160-21166 (1996)
Ilka Warshawsky, Joachim Herz,
George J. Broze, Jr., and Alan L. Schwartz
The Low Density Lipoprotein Receptor-related Protein Can Function
Independently from Heparan Sulfate Proteoglycans in Tissue Factor
Pathway Inhibitor Endocytosis.
J. Biol. Chem. 271, 25873-25879 (1996)
Photini Sinnis, Thomas E. Willnow, Marcelo R.S. Briones, Joachim Herz, and Victor
Nussenzweig
Remnant
Lipoproteins
Inhibit Malaria Sporozoite Invasion of Hepatocytes.
J. Exp. Med. 184, 945-954 (1996)
Astrid Rohlmann, Michael Gotthardt, Thomas E. Willnow, Robert E.
Hammer and Joachim Herz
Sustained
Somatic
Gene Inactivation By Viral Transfer of Cre Recombinase.
Nature Biotechnology 14, 1562-1565 (1996)
Vardiella L. Meiner, Sylvaine Cases, Heather M. Myers, Eric R.
Sande, Stefano Bellosta, Morris Schambelan, Robert E. Pitas, James
McGuire, Joachim Herz,
Robert V. Farese, Jr.
Disruption of the acyl-CoA:cholesterol acyltransferase gene in
mice: Evidence suggesting multiple cholesterol esterification
enzymes in mammals.
Proc. Natl. Acad. Sci. USA 93, 14041-14046 (1996)
Joachim Herz, Thomas E.
Willnow, Robert V. Farese, Jr.
Cholesterol, Hedgehog, and embryogenesis.
Nature Genetics 15, 123-124 (1997)
Robert C. Johnson, Susan M. Chapman, Zhao-Ming Dong, Jose M.
Ordovas, Tanya N. Mayadas, Joachim
Herz, Richard O. Hynes, Ernst J. Schaefer, and Denisa D.
Wagner
Absence
of
P-Selectin Delays Fatty Streak Formation in Mice.
J. Clin. Invest. 99, 1037-43 (1997)
Christian Brandes, Sabine Novak, Walter Stockinger, Joachim Herz,Wolfgang J.
Schneider, and Johannes Nimpf
Avian
and
murine LR8B and human apolipoprotein E receptor 2: differentially
spliced products from corresponding genes.
Genomics 42, 185-91 (1997)
Michael S. Brown, Joachim
Herz, and Joseph L. Goldstein
LDL-Receptor
Structure
- Calcium Cages, Acid Baths and Recycling Receptors.
Nature 388, 629-630 (1997)
Deltef Storm, Joachim Herz,
Peter Trinder, and Michael Loos
C1-Inhibitor-C1s
Complexes
Are Internalized and Degraded by the Low Density Lipoprotein
Receptor-related Protein.
J. Biol. Chem. 272, 31043-31050 (1997)
Hitoshi Shimano, Iichiro Shimomura, Robert E. Hammer, Joachim Herz, Joseph L.
Goldstein, Michael S. Brown, and Jay D. Horton
Elevated Levels of SREBP-2 and Cholesterol Synthesis in Livers of
Mice Homozygous for a Targeted Disruption of the SREBP-1 Gene.
J. Clin. Invest. 100, 2115-2124 (1997)
Astrid Rohlmann, Michael Gotthardt, Robert E. Hammer, and Joachim Herz
Inducible
Inactivation
of Hepatic LRP Gene By Cre-Mediated Recombination Confirms Role of
LRP in Clearance of Chylomicron Remnants.
J. Clin. Invest. 101, 689-695 (1998)
Robert V. Farese, Jr., and Joachim
Herz
Cholesterol
and
Embryogenesis.
Trends in Genetics 14, 115-120 (1998)
Thomas Hiesberger, Silke Hüttler, Astrid Rohlmann, Wolfgang
Schneider, Konrad Sandhoff, and Joachim
Herz
Cellular Uptake of Saposin (SAP) Precursor and Lysosomal Delivery
by the Low Density Lipoprotein Receptor-Related Protein (LRP)
EMBO J. 17, 4617-4625 (1998)
Murielle M. Véniant, Constance H. Zlot, Rosemary L. Walzem, Vincenzo
Pierotti, Robert Driscoll, David Dichek, Joachim Herz, and Stephen G. Young
Lipoprotein Clearance Mechanisms in LDL Receptor-Deficient
"Apo-B48-only" and "Apo-B100-only" Mice
J. Clin. Invest. 102, 1559-1568 (1998)
Marion Trommsdorff, Jean-Paul Borg, Benjamin Margolis, and Joachim Herz
Interaction of cytosolic adaptor proteins with neuronal apoE
receptors and the amyloid precursor protein.
J. Biol. Chem. 273, 33556-33560 (1998)
Joachim Herz and Robert V.
Farese, Jr.
The
LDL
Receptor Gene Family, Apolipoprotein B and Cholesterol In
Embryonic Development.
Journal of Nutrition 129, 473S-475S (1999)
Bart J.M. van Vlijmen and Joachim
Herz
Gene
Targets
and Approaches for Raising HDL.
Circulation 99, 12-14 (1999)
Anders Nykjaer, Duska Dragun, Diego Walther, Henrik Vorum, Christian
Jacobsen, Joachim Herz,
Flemming Melsen, Erik Isloe Christensen, and Thomas E. Willnow
An endocytic pathway essential for renal uptake and activation of
the steroid 25-(OH) vitamin D3.
Cell 96, 507-515 (1999)
Marion Trommsdorff, Michael Gotthardt, Thomas Hiesberger, John
Shelton, Walter Stockinger, Johannes Nimpf, Robert E. Hammer, James
A. Richardson, and Joachim Herz
Reeler/Disabled-Like
Disruption
of Neuronal Migration in Knockout Mice Lacking the VLDL receptor
and ApoE receptor-2.
Cell 97, 689-701 (1999)
Atsushi Sato, Yoshimi Shimada, Joachim
Herz, Tokuo Yamamoto, and Hisato Jingami
39-kDa receptor-associated protein (RAP) facilitates secretion and
ligand binding of extracellular region of
very-low-density-lipoprotein receptor: implications for a distinct
pathway from low-density-lipoprotein receptor.
Biochem. J. 341, 377-383 (1999)
Thomas E. Willnow, Anders Nykjaer, Joachim
Herz
Lipoprotein
receptors:
new roles for ancient proteins
Nature Cell Biology 1, 157-162 (1999)
Thomas Hiesberger, Marion Trommsdorff, Brian W. Howell, Andre
Goffinet, Marc C. Mumby, Jonathan A. Cooper, and Joachim Herz
Direct
binding
of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine
phosphorylation of the adaptor protein Disabled-1 and modulates
tau phosphorylation.
Neuron 24, 481-489 (1999)
Bart J.M. van Vlijmen, Astrid Rohlmann, André Bensadoun, Shallee
Page, I. Sophie T. Bos, Theo J.C. van Berkel, Louis M. Havekes, and
Joachim Herz
An
Extrahepatic
RAP-Sensitive Mechanism Is Involved in the Metabolism of
Triglyceride-Rich Lipoproteins.
J. Biol. Chem., 274, 35219–35226 (1999)
Narimon Honarpour, Chunying Du, James A. Richardson, Robert E.
Hammer, Xiaodong Wang, Joachim
Herz
Adult Apaf-1-Deficient Mice Exhibit Male Infertility.
Developmental Biology 218, 248-258 (2000)
Patricia Marshall, Astrid Rohlmann, Victor Nussenzweig, Joachim Herz, and Photini Sinnis
Plasmodium Sporozoites Invade Cells with Targeted Deletions in the
LDL Receptor Related Protein (LRP).
Mol. Biochem. Parasitol. 106, 293-298 (2000)
Joachim Herz, Michael
Gotthardt, and Thomas E. Willnow
Cellular
Signaling
By Lipoprotein Receptors.
Current Opinion in Lipidology 11, 161-166 (2000)
Michael Gotthardt, Marion Trommsdorff, Matthew F. Nevitt, John
Shelton, James A. Richardson, Walter Stockinger, Johannes Nimpf, and
Joachim Herz
Interactions
of
the low density lipoprotein (LDL) receptor gene family with
cytosolic adaptor and scaffold proteins suggest diverse biological
functions in cellular communication and signal transduction.
J. Biol. Chem. 275, 25616-25624 (2000)
Walter Stockinger, Christian Brandes, Daniela Fasching, Marcela
Hermann, Michael Gotthardt, Joachim
Herz, Wolfgang J. Schneider, and Johannes Nimpf
The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and
2.
J. Biol. Chem. 275, 25625-25632 (2000)
Joachim Herz and Uwe Beffert
Apolipoprotein E receptors: linking brain development and
Alzheimer disease.
Nature Neuroscience Rev. 1, 51-58 (2000)
Brian W. Howell and Joachim Herz
The
LDL
Receptor Gene Family: Signaling Functions in Development.
Current Opinion in Neuroscience 11, 74-81 (2001)
Joachim Herz
Lipoprotein
receptors:
Beacons to neurons?
Trends in Neuroscience 24, 193-195 (2001)
Joachim Herz
The
LDL
Receptor Gene Family: (Un)Expected Signal Transducers in the Brain
Neuron 29, 571-581 (2001)
Joachim Herz
Deconstructing
the
LDL receptor – a rhapsody in pieces
Nature Stuctural Biology 8, 476-8 (2001)
Narimon Honarpour, Katsuhiko Tabuchi, Jeffrey M. Stark, Robert E.
Hammer, Thomas C. Sudhof, Luis F. Parada, Xiaodong Wang, James A.
Richardson, and Joachim Herz
Embryonic
neuronal
death due to neurotrophin and neurotransmitter deprivation occurs
independent of Apaf-1.
Neuroscience 106(2):263-74 (2001)
Narimon Honarpour, Sandra Gilbert, Bruce Lahn, Xiaodong Wang, and Joachim Herz
Apaf-1
Deficiency
and Neural Tube Closure Defects in forebrain-overgrowth (fog)
Mice.
Proc. Natl. Acad. Sci., 98(17):9683-7 (2001)
Joachim Herz and Dudley K.
Strickland
LRP:
a
multifunctional scavenger and signaling receptor.
J. Clin. Invest. 108(6):779-84 (2001)
Carl Gebhardt, Domenico Del Turco, Alexander Drakew, Albrecht
Tielsch, Joachim Herz,
Michael Frotscher, and Thomas Deller
Abnormal positioning of granule cells alters afferent fiber
distribution in the mouse fascia dentata: Morphologic evidence
from reeler, apolipoprotein E receptor 2-, and very low density
lipoprotein receptor knockout mice.
J Comp Neurol. 445, 278-92 (2002)
Joachim Herz and Hans. H.
Bock
Lipoprotein Receptors in the Nervous System
Ann. Rev. Biochem. 71, 405-34 (2002)
Philippe Boucher, Pingsheng Liu, Michael Gotthardt, Thomas
Hiesberger, Richard G. W. Anderson, and Joachim Herz
PDGF mediates tyrosine phosphorylation of the cytoplasmic domain
of the LDL receptor-related protein (LRP) in caveolae.
J. Biol. Chem., 277, 15507-13 (2002)
Petra May, Y. Krishna Reddy, and Joachim
Herz
Proteolytic processing of LRP mediates regulated release of its
intracellular domain.
J. Biol. Chem. 277, 18736-43 (2002)
Rita Holtwick, Michael Gotthardt, Boris Skryabin, Martin Steinmetz,
Regine Potthast, Bernd Zetsche, Robert E. Hammer, Joachim Herz, and Michaela Kuhn
Smooth
muscle-selective
deletion of guanylyl cyclase-A prevents the acute but not chronic
effects of ANP on blood pressure.
Proc. Natl. Acad. Sci. 99, 7142-7147 (2002)
Alexander Drakew, Thomas Deller, Bernd Heimrich, Carl Gebhardt,
Domenico Del Turco, Albrecht Tielsch, Eckart Förster, Joachim Herz, and Michael
Frotscher
Dentate Granule Cells in Reeler Mutants and VLDLR and ApoER2
Knockout Mice.
Exp. Neurol. 176, 12-24 (2002)
Edwin J. Weeber, Uwe Beffert, Chris Jones, Jill M. Christian, Eckart
Förster, J. David Sweatt, and Joachim
Herz
Reelin
and
ApoE receptors cooperate to enhance hippocampal synaptic
plasticity and learning.
J Biol Chem., 277, 39944-39952 (2002)
Uwe Beffert, Gerardo Morfini, Hans. H. Bock, Huichuan Reyna, Scott
T. Brady, and Joachim Herz
Reelin-mediated signaling locally regulates PKB/Akt and GSK-3ß
J. Biol.Chem. 277, 49958-49964 (2002)
Jochen Brich, Feng-Shiun Shie, Brian W. Howell, Renhua Li, Katalin
Tus, Edward K. Wakeland, Lee-Way Jin, Marc Mumby, Gary Churchill, Joachim Herz, and Jonathan A.
Cooper
Genetic modulation of tau phosphorylation in the mouse
J. Neuroscience 23, 187-192
(2003) Alzforum
commentary
Hans H. Bock and Joachim Herz
Reelin Activates Src Family Tyrosine Kinases in Neurons
Current Biology 13, 18-26 (2003)
Peter Marschang and Joachim Herz
Mouse
models
as tools for dissecting disorders of lipoprotein metabolism
Seminars in Cell and Developmental Biology 14, 25-35 (2003)
Michael Gotthardt, Robert E. Hammer, Norbert Hübner, Jan Monti,
Christian C. Witt, Mark McNabb, James A. Richardson, Henk Granzier,
Siegfried Labeit, and Joachim Herz
Conditional
expression
of mutant M-line titins results in cardiomyopathy with altered
sarcomere structure.
J Biol Chem. 278, 6059-6065 (2003)
Niels Bovenschen, Joachim Herz,
Jos M. Grimbergen, Peter J. Lenting, Louis M. Havekes, Koen Mertens,
and Bart J. M. van Vlijmen
Elevated
plasma
factor VIII in a mouse model of low-density lipoprotein receptor
related protein deficiency
Blood 101, 3933-3939 (2003)
Joachim Herz and Peter
Marschang
Coaxing
the
LDL Receptor Family into the Fold
Cell 112, 289-292 (2003)
- Marc-Estienne Roehrich, Vincent Mooser, Vincent Lenain, Joachim Herz, Johannes
Nimpf, Salman Azhar, Martine Bideau, Alessandro Capponi, Pascal
Nicod, Jacques-Antoine Haefliger, and Gérard Waeber
- Insulin-secreting
ß-cell dysfunction
induced by human lipoproteins
- J. Biol. Chem. 278, 18368-18375 (2003)
Petra May, Hans H. Bock, and Joachim
Herz
Integration
of
Endocytosis and Signal Transduction by Lipoprotein Receptors
Sci. STKE 2003, pe12 (2003).
Philippe Boucher, Michael Gotthardt, Wei-Ping Li, Richard G.W.
Anderson, Joachim Herz
LRP:
Role
in Vascular Wall Integrity and Protection from Atherosclerosis
Science 300, 329-332
(2003) Center
Times
Karl Heinz Weiss, Celine Johanssen, Albrecht Tielsch, Joachim Herz, Thomas Deller,
Michael Frotscher, and Eckart Förster
Malformation
of
the Radial Glial Scaffold in the Dentate Gyrus of Reeler Mice,
Scrambler Mice, and ApoER2/VLDLR-Deficient Mice
Journal of Comparative Neurology 460, 56–65 (2003)
Olav M. Andersen, Ching-Hey Yeung, Henrik Vorum, Maren
Wellner, Thomas K. Andreassen, Bettina Erdmann, Eva-Christina
Mueller, Joachim Herz,
Albrecht Otto, Trevor G. Cooper, and Thomas E. Willnow
Essential
role
of the apolipoprotein E receptor-2 in sperm development.
J. Biol. Chem. 278, 23989-95
(2003)
Peggy C. Stolt, Hyesung Jeon, Hyun Kyu Song, Joachim Herz, Michael J. Eck,
and Stephen C. Blacklow
Origins of Peptide Selectivity and Phosphoinositide Binding
Revealed by Structures of Disabled-1 PTB Domain Complexes.
Structure 11, 569-79
(2003)
Petra May and Joachim Herz
LDL
Receptor-Related
Proteins
in Neurodevelopment.
Traffic 4, 291-301 (2003)
Christopher Jones, Robert E. Hammer, Wei-Ping Li, Jonathan C. Cohen,
Helen H. Hobbs, and Joachim Herz
Normal
Sorting,
But Defective Endocytosis of the LDL Receptor in Mice with
Autosomal Recessive Hypercholesterolemia.
J. Biol. Chem. 278, 29024-29030 (2003)
Petra May, Hans H. Bock, Johannes Nimpf, and Joachim Herz
Differential
Glycosylation
Regulates Processing of Lipoprotein Receptors by gamma-Secretase.
J. Biol. Chem. 278, 37386–37392 (2003)
Eva Hartfuss, Eckart Förster, Hans H. Bock, Michael A. Hack, Pierre
Leprince, Juan M. Luque, Joachim
Herz, Michael Frotscher, and Magdalena Götz
Reelin
signaling
directly affects radial glia morphology and biochemical
maturation.
Development 130, 4597-4609 (2003)
Hans H. Bock, Yves Jossin, Pingsheng Liu, Eckart Förster, Petra May,
André M. Goffinet, and Joachim
Herz
PI3-Kinase
interacts
with the adaptor protein Dab1 in response to Reelin signaling and
is required for normal cortical lamination.
J. Biol. Chem. 278, 38772–38779 (2003)
Amir H. Assadi, Guangcheng Zhang, Uwe Beffert, Robert S. McNeil, Amy
L. Renfro, Sanyong Niu, Carlo C. Quattrocchi, Barbara A. Antalffy,
Michael Sheldon, Dawna D. Armstrong, Anthony Wynshaw-Boris, Joachim Herz, Gabriella
D’Arcangelo, and Gary D. Clark
Interaction
of
reelin signaling and Lis1 in brain development.
Nature Genetics 35, 270-276 (2003)
Joachim Herz
LRP:
a
bright
beacon at the blood-brain-barrier
J. Clin. Invest. 112, 1483-1485
(2003)
Uwe Beffert, Peggy C. Stolt, and Joachim
Herz
Functions
of
lipoprotein receptors in neurons
Journal of Lipid Research 45, 403–409 (2004)
Marcel Vergés, Andre Bensadoun, Joachim
Herz, John D. Belcher and Richard J. Havel
Endocytosis
of
hepatic lipase and lipoprotein lipase into rat liver hepatocytes
in vivo is mediated by the low density lipoprotein
receptor-related protein.
J. Biol. Chem. 279, 9030-9036 (2004)
Vera Strasser, Daniela Fasching, Christoph Hauser, Harald Mayer,
Hans H. Bock, Thomas Hiesberger, Joachim Herz, Edwin J.
Weeber, J. David Sweatt, Albéna Pramatarova, Brian Howell, Wolfgang
J. Schneider, and Johannes Nimpf
Receptor
Clustering
is involved in Reelin signaling.
Mol. Cell. Biol. 24, 1378-1386 (2004)
Yves Jossin, Nina Ignatova, Thomas Hiesberger, Joachim Herz,
Catherine Lambert de Rouvroit, and André M. Goffinet
The
central
fragment of Reelin, generated by proteolytic processing in vivo,
is critical to its function during cortical plate development.
J. Neuroscience 24, 514 –521 (2004)
Sonia M. S. Espirito Santo, Nuno M. M. Pires, Gery Gerritsen, Niels
Bovenschen, Ko Willems van Dijk, Hans M. G. Princen, André
Bensadoun, Joachim Herz, Louis M. Havekes, and Bart J. M.
van Vlijmen
Hepatic
LDL
Receptor-related Protein Deficiency in Mice Increases
Atherosclerosis Independent of Plasma Cholesterol.
Blood 103, 3777-3782
(2004)
Uwe Beffert, Edwin Weeber, Gerardo Morfini, Jane Ko, Scott T. Brady,
Li-Huei Tsai, J. David Sweatt, and Joachim Herz
Reelin
and
Cdk5 dependent signals cooperate in regulating neuronal migration
and synaptic transmission.
J. Neuroscience 24, 1897-1906 (2004)
Joachim Herz and David Y. Hui
Lipoprotein
Receptors
in the Vascular Wall.
Current Opinion in Lipidology 15, 175-181 (2004)
Peter Marschang, Jochen Brich, Edwin J. Weeber, J. David Sweatt,
John M. Shelton, James A. Richardson, Robert E. Hammer, and Joachim Herz
Normal
Development
and Fertility of Knockout Mice Lacking the Tumor Suppressor Gene
LRP1b Suggest Functional Compensation by LRP1.
Mol. Cell. Biol. 24, 3782–3793 (2004)
Hans H. Bock, Yves Jossin, Petra May, Oliver Bergner, and Joachim Herz
Apolipoprotein
E
receptors are required for Reelin-induced proteasomal degradation
of the neuronal adaptor protein Disabled-1.
J. Biol. Chem. 279, 33471-33479 (2004)
John D. Minna, Adi F. Gazdar, Stephen R. Sprang, Joachim Herz
A
Bull’s Eye for Targeted Lung Cancer Therapy
Science 304, 1458-1461 (2004)
Petra May, Astrid Rohlmann, Hans H. Bock, Kai Zurhove, Jamey D.
Marth, Eike D. Schomburg, Jeffrey L. Noebels, Uwe Beffert, J. David
Sweatt, Edwin J. Weeber, and Joachim
Herz
Neuronal
LRP1
Functionally Associates with Postsynaptic Proteins Is Required for
Normal Motor Function in Mice.
Mol. Cell. Biol. 24, 8872-8883 (2004)
Adi F. Gazdar, Hisayuki Shigematsu, Joachim Herz, and John D. Minna
Mutations
and
addiction to EGFR: the Achilles ‘heal’ of lung cancers?
Trends in Molecular Medicine 10, 481-486 (2004)
Caroline Petit-Turcotte, Nicole Aumont, Uwe Beffert, Doris Dea, Joachim Herz, Judes Poirier
The
apoE
receptor apoER2 is involved in the maintenance of efficient
synaptic plasticity.
Neurobiology of Aging 26, 195–206 (2005)
Peggy C. Stolt, Ying Chen, Pingsheng Liu, Hans H. Bock, Stephen C.
Blacklow, and Joachim Herz
Phosphoinositide
binding
by the Disabled-1 PTB domain is necessary for membrane
localization and Reelin signal transduction.
J. Biol. Chem. 280, 9671-9677
(2005)
Aparna R. Aiyera, Narimon Honarpour, Joachim Herz, Deepak Srivastava
Loss
of
Apaf-1 leads to partial rescue of the HAND2-null phenotype.
Dev. Biol. 278, 155-162 (2005)
Hisayuki Shigematsu, Li Lin, Takao Takahashi, Masaharu Nomura,
Makoto Suzuki, Ignacio I. Wistuba, Kwun M. Fong, Huei Lee, Shinichi
Toyooka, Nobuyoshi Shimizu, Takehiko Fujisawa, Ziding Feng, Jack A.
Roth, Joachim Herz, John D.
Minna, Adi F. Gazdar
Clinical
and
Biological Features Associated With Epidermal Growth Factor
Receptor Gene Mutations in Lung Cancers.
J. Natl.
Cancer Inst. 97, 339-346 (2005)
Yoshiharu Takayama, Petra May, Richard G. W. Anderson, and Joachim Herz
Low-density
lipoprotein
receptor-related
protein 1 (LRP1) controls endocytosis and c-Cbl-mediated
ubiquitination of the platelet-derived growth factor receptor β
(PDGFRβ).
J. Biol. Chem. 280, 18504-18510 (2005)
Uwe Beffert, Edwin J. Weeber, Andre Durudas, Shenfeng Qiu, Irene
Masiulis, J. David Sweatt, Wei-Ping Li, Giselind Adelmann, Michael
Frotscher, Robert E. Hammer, and Joachim
Herz
Modulation
of
Synaptic Plasticity and Memory by Reelin Involves Differential
Splicing of the Lipoprotein Receptor Apoer2.
Neuron 47, 567-579 (2005) Alzforum
Commentary Neuron Preview
Ying Chen, Uwe Beffert, Mert Ertunc, Tie-Shan Tang, Ege T. Kavalali,
Ilya Bezprozvanny, Joachim Herz
Reelin
Modulates
NMDA Receptor Activity in Cortical Neurons.
J. Neuroscience 25, 8209–8216 (2005)
Hiroshi Kurosu, Masaya Yamamoto, Jeremy D. Clark, Johanne V. Pastor,
Animesh Nandi, Prem Gurnani, Owen P. McGuinness, Hirotaka Chikuda,
Masayuki Yamaguchi, Hiroshi Kawaguchi, Iichiro Shimomura, Yoshiharu
Takayama, Joachim Herz, C.
Ronald Kahn, Kevin P. Rosenblatt, and Makoto Kuro-o
Suppression
of
Aging in Mice by the Hormone Klotho.
Science 309, 1829-1833
(2005)
Petra May, Joachim Herz,
Hans H. Bock
Molecular
mechanisms
of lipoprotein receptor signalling.
Cell Mol Life Sci. 62,
2325-2338 (2005)
Rita Garuti, Christopher Jones, Wei-Ping Li, Peter Michaely, Joachim Herz, Robert D. Gerard,
Jonathan C. Cohen, Helen H. Hobbs
The
modular
adaptor protein ARH promotes LDLR clustering into
clathrin-coated pits.
J. Biol. Chem. 280, 40996-1004 (2005)
Eric B. Johnson, Robert E. Hammer, and Joachim Herz
Abnormal
development
of the apical ectodermal ridge and polysyndactyly in MEGF7
deficient mice.
Hum. Mol. Gen. 14, 3523-3538
(2005)
Suzanne Guénette, Yang Chang, Thomas Hiesberger, James A.
Richardson, Christopher B. Eckman, Elizabeth A. Eckman, Robert E.
Hammer and Joachim Herz
Essential
roles
for the FE65 amyloid precursor protein-interacting proteins in
brain development.
EMBO J. 25, 420-431 (2006)
Uwe Beffert, Andre Durudas, Edwin J. Weeber, Peggy C. Stolt, Klaus
M. Giehl, J. David Sweatt, Robert E. Hammer, and Joachim Herz
Functional
Dissection
of Reelin Signaling by Site-Directed Disruption of Disabled-1
Adaptor Binding to Apolipoprotein E Receptor 2: Distinct Roles in
Development and Synaptic Plasticity.
J. Neuroscience 26, 2041–2052 (2006)
Chunzhang Cao, Daniel A. Lawrence, Yang Li, Christine A.F. Von
Arnim, Joachim Herz, Enming
J. Su, Alexandra Makarova, Bradley T. Hyman, Dudley K. Strickland,
and Li Zhang
Endocytic
receptor
LRP together with tPA and PAI-I coordinates Mac-1-dependent
macrophage migration.
EMBO J. 25, 1860-1870
(2006)
Xiaobiao Li, Joachim Herz,
and Denis Monard
Activation
of
ERK signaling upon alternative protease nexin-1 internalization
mediated by syndecan-1.
J. Cellular Biochemistry 99, 936-951 (2006)
Eric B. Johnson, David J. Steffen, Kristen W. Lynch, and Joachim Herz
Defective
Splicing
of Megf7/Lrp4, a Regulator of Distal Limb Development, in
Autosomal Recessive Mulefoot Disease
Genomics 88, 600-609 (2006)
Joachim Herz
The
Switch
on the RAPper's Necklace...
Molecular Cell 23, 451-455 (2006)
Hu L., Boesten L.S., May P., Herz
J., Bovenschen N., Huisman M.V., Berbee J.F., Havekes L.M.,
van Vlijmen B.J., Tamsma J.T.
Macrophage
Low-Density
Lipoprotein Receptor-Related Protein Deficiency Enhances
Atherosclerosis in ApoE/LDLR Double Knockout Mice
Arterioscler Thromb Vasc Biol. 26,
2710-2715 (2006)
Joachim Herz and Ying Chen
Reelin,
lipoprotein
receptors and synaptic plasticity
Nature Reviews Neuroscience 7, 850-859 (2006)
Uwe Beffert, Farnas Nematollah-Farsian, Irene Masiulis, Robert
Hammer, Sung Ok Yoon, Klaus M. Giehl, and Joachim Herz
ApoE
receptor
2 controls neuronal survival the adult brain
Current Biology 16, 2446-2452
(2006)
commentary
Christopher Jones, Rita Garuti, Peter Michaely, Wei-Ping Li, Nobuyo
Maeda, Jonathan C. Cohen, Joachim
Herz, and Helen H. Hobbs
Preservation
of
VLDL remnant clearance attenuates the phenotype of autosomal
recessive hypercholesterolemia
J. Clin. Invest. 117, 165-174 (2007)
Joachim Herz
Overview:
The
Long and Winding Road to Understanding Alzheimer’s Disease.
Neuron 53, 477 - 479 (2007)
Guangcheng Zhang, Amir H.
Assadi, Robert S. McNeil, Uwe Beffert, Anthony Wynshaw-Boris, Joachim Herz, Gary D. Clark, Gabriella D’Arcangelo
The
Pafah1b
Complex Interacts with the Reelin Receptor VLDLR.
PLoS ONE 2, e252, 1-9 (2007) comments
and
citations
Philippe Boucher, Wei-Ping Li, Rachel L. Matz,
Yoshiharu Takayama, Johan Auwerx, Richard G.W. Anderson, Joachim Herz
LRP1
Functions
as an Atheroprotective Integrator of TGFβ and PDFG Signals in the
Vascular Wall: Implications for Marfan Syndrome
PLoS ONE 2, e448, 1-7 (2007) comments
and
citations
Susanna M. Hofmann, Li Zhou, Diego Perez-Tilve, Todd
Greer, Erin Grant, Lauren Wancata, Andrew Thomas, Paul T.
Pfluger, Joshua E. Basford, Dean Gilham, Joachim Herz, Matthias H.
Tschöp, and David Y. Hui
Adipocyte
LDL
receptor related protein-1 expression modulates postprandial
lipid transport, glucose homeostasis, and adiposity
J. Clin. Invest. 117, 3271-3282 (2007)
Qiang Liu, Celina V. Zerbinatti, Juan Zhang, Hyang-Sook Hoe,
Baiping Wang, Sarah L. Cole, Joachim
Herz, Louis Muglia, and Guojun Bu
Amyloid
Precursor
Protein Regulates Brain Apolipoprotein E and Cholesterol
Metabolism through Lipoprotein Receptor LRP1
Neuron 56, 66-78 (2007)
Alin L. Akopians, Alex H. Babayan, Uwe Beffert, Joachim Herz, Allan I.
Basbaum and Patricia E. Phelps
Contribution
of
the Reelin signaling pathways to nociceptive processing
Eur. J. Neuroscience 27, 523–537 (2008)
Matt Larouche, Uwe Beffert, Joachim Herz, and Richard
Hawkes
The
Reelin
Receptors Apoer2 and Vldlr Coordinate the Patterning of
Purkinje Cell Topography in the Developing Mouse Cerebellum
PLoS ONE 3, e1653, 1-14 (2008) comments
and
citations
Robert Lukowski, Pascal Weinmeister, Dominik Bernhard, Susanne
Feil, Michael Gotthardt, Joachim Herz, Steffen
Massberg, Alma Zernecke, Christian Weber, Franz Hofmann and Robert Feil
Arterioscler Thromb Vasc Biol. 28,
1244-1250 (2008)
Joachim Herz, Kym M.
Boycott, Jillian S. Parboosingh
"Devolution" of bipedality.
Proc Natl Acad Sci U S A. 105,
E25 (2008)
Kai Zurhove, Chikako Nakajima, Joachim
Herz, Hans H. Bock, Petra May
γ-Secretase
Limits
the Inflammatory Response Through the Processing of LRP1.
Science Signaling 1, ra15, 1-12 (2008)
Science
Signaling
Podcast - Interview
with Petra May
Atsushi Ohazama, Eric B.
Johnson, Masato S. Ota, Hong J. Choi, Thantrira Porntaveetus, Shelly Oommen,
Nobuyuki Itoh, Kazuhiro Eto, Amel Gritli- Linde, Joachim Herz, and Paul T. Sharpe
Lrp4
modulates
extracellular integration of cell signaling pathways in
development.
PLoS ONE 3, e4092, 1-11
(2008) comments
and
citations
Joachim Herz, Ying Chen,
Irene Masiulis, Li Zhou
Expanding
Functions
of Lipoprotein Receptors.
J. Lipid Res. 50, S287–S292 (2009)
Jérome Terrand, Véronique Bruban, Li Zhou, Wanfeng Gong,
Zeina El Asmar, Petra May, Kai Zurhove, Philipp Hafner, Claude
Philippe, Estelle Woldt, Rachel L. Matz, Céline Gracia, Daniel
Metzger, Johan Auwerx, Joachim
Herz, Philippe Boucher
LRP1
controls
intracellular cholesterol storage and fatty acid synthesis
through Wnt signaling.
J. Biol. Chem. 284, 381-388 (2009)
Irene Masiulis, Timothy A. Quill, Raymond F. Burk, and Joachim Herz
Differential functions of the
Apoer2 intracellular domain in selenium uptake and cell
signaling.
Biol. Chem. 390, 67-73 (2009)
Kym M Boycott, Carsten
Bonnemann, Joachim Herz,
Stephanie Neuert, Chandree Beaulieu, James N Scott, Anuradha
Venkatasubramanian, Jillian S Parboosingh
Mutations
in
VLDLR as a Cause for Autosomal Recessive Cerebellar Ataxia
with Mental Retardation (Dysequilibrium Syndrome)
J. Child Neurol. 24: 1310-1315 (2009)
Joachim Herz
ApoE
receptors
in the nervous system.
Current Opinion in Lipidology 20, 190-196 (2009)
Murat Durakoglugil, Ying Chen, Charles L. White, Ege T.
Kavalali, and Joachim Herz
Reelin
Signaling
Antagonizes
β-Amyloid at the
Synapse.
Proc Natl Acad Sci USA 106, 15938–15943 (2009)
Alzforum
commentary Center
Times
Li Zhou, Hong Y. Choi, Wi-Ping Li, Fang Xu, Joachim Herz
LRP1
Controls
cPLA2 Phosphorylation, ABCA1 Expression and
Cellular Cholesterol Export.
PLoS ONE 4, e6853, 1-9 (2009) comments
and
citations
Li Zhou, Yoshiharu Takayama, Philippe Boucher, Michelle D.
Tallquist, Joachim Herz
LRP1
Regulates
the Architecture of the Vascular Wall by Controlling PDGFRβ-Dependent
Phosphatidylinositol 3-Kinase Activation.
PLoS ONE 4, e6922, 1-11
(2009) comments
and
citations
Joshua E. Basford, Zachary W.Q. Moore, Li Zhou, Joachim Herz, David Y. Hui
Smooth
Muscle
LDL Receptor-related Protein-1 Inactivation Reduces Vascular
Reactivity and Promotes Injury-induced Neointima Formation.
Arterioscl. Thromb. Vasc. Biol.,
29, 1772-1778 (2009)
Mark P. Jedrychowski, Carlos A. Gartner, Steven P. Gygi, Li
Zhou, Joachim Herz,
Konstantin V. Kandror and Paul F. Pilch
Proteomic
analysis
of GLUT4 storage vesicles (GSVS) reveals low-density
lipoprotein receptor-related protein 1 (LRP1) to be an
important vesicle component and target of insulin signaling.
J Biol Chem. 285(1):104-114
(2010) [Oct 28, 2009. [Epub ahead of print]]
Atsushi Ohazama, James
Blackburn, Thantrira Porntaveetus, Masato Ota, Hong Choi, Eric
Johnson, Philip Myers, Shelly Oommen, Kazuhiro Eto, John
Kessler, Takashi Kondo, Gareth Fraser, J. Todd Streelman, Ulyses
Pardiñas, Abigail Tucker, Pablo Ortiz, Cyril Charles, Laurent
Viriot, Joachim Herz,
Paul Sharpe
A
role for suppressed incisor cuspal morphogenesis in the
evolution of mammalian heterodont dentition.
Proc Natl Acad Sci USA 107, 92-97 (2010) [Epub 2009 Dec 14]
Hong Y. Choi, Marco Dieckmann, Joachim
Herz, Andreas Niemeier
Lrp4,
a
Novel Receptor for Dickkopf 1 and Sclerostin, Is Expressed by
Osteoblasts and Regulates Bone Growth and Turnover In Vivo.
PLoS ONE 4, e7930, 1-10 (2009) comments
and
citations
Chantelle F. Sephton, Shannon
K. Good, Stan Atkin, Colleen M. Dewey, Paul Mayer, Joachim Herz, and Gang Yu
TDP-43
is
a developmentally-regulated protein essential for early
embryonic development.
J. Biol. Chem. 285, 6826-6834 (2010) [Epub 2009 Dec 29]
Martin F. Dietrich, Louise van der Weyden, Haydn M. Prosser,
Allan Bradley, Joachim Herz (corresponding
author), David J. Adams
Ectodomains of the LDL
Receptor-related Proteins LRP1b and LRP4 Have
Anchorage-Independent Functions in Vivo.
PLoS One 5, e9960, 1-7
(2010) comments
and citations
Courtney M. Karner, Martin F. Dietrich, Eric B. Johnson, Natalie
Kappesser, Christian Tennert, Ferda Percin, Bernd Wollnik,
Thomas J. Carroll, Joachim
Herz
Lrp4 Regulates
Initiation of Ureteric Budding and Is Crucial for Kidney
Formation – A Mouse Model for Cenani-Lenz Syndrome.
PLoS One 5, e10418, 1-9
(2010) comments
and
citations
Yun Li, Barbara Pawlik, Nursel Elcioglu, Mona Aglan, Hülya
Kayserili, Gökhan Yigit, Ferda Percin, Frances Goodman, Gudrun
Nürnberg, Asim Cenani, Jill Urquhart, Boi-Dinh Chung, Samira
Ismail, Khalda Amr, Ayca D. Aslanger, Christian Becker,
Christian Netzer, Pete Scambler, Wafaa Eyaid, Hanan Hamamy, Jill
Clayton-Smith, Raoul Hennekam, Peter Nürnberg, Joachim Herz, Samia A.
Temtamy, and Bernd Wollnik
LRP4 Mutations Alter
Wnt/ß-Catenin Signaling and Cause Limb and Kidney
Malformations in Cenani-Lenz Syndrome.
The American Journal of Human
Genetics 86, 696-706 (2010)
[Epub 2010 Apr 8]
Eckart Förster, Hans H. Bock,
Joachim Herz, Xuejun Chai, Michael Frotscher, and
Shanting Zhao
Emerging topics in
Reelin function.
European Journal of Neuroscience 31, 1511–1518 (2010)
Ying Chen, Murat
Durakoglugil, Xunde Xian, and Joachim
Herz
ApoE4 reduces glutamate
receptor function and synaptic plasticity by selectively
impairing ApoE receptor recycling.
Proc Natl Acad Sci USA 107, 12011-12016 [Epub 2010 Jun 14] (2010) Alzforum
commentary
Center
Times AHAF
Bianka Brunne, Shanting Zhao,
Amin Derouiche, Joachim Herz,
Petra May, Michael Frotscher, Hans H. Bock
Origin,
maturation, and astroglial transformation of secondary radial
glial cells in the developing dentate gyrus.
Glia
58(13):1553-69 (2010) Jun 14. [Epub ahead of print]
Marco Dieckmann, Martin F. Dietrich, Joachim Herz
Lipoprotein
receptors--an evolutionarily ancient multifunctional receptor
family.
Biological Chemistry 391(11):1341-63 (2010)
Jost Leemhuis, Elisabeth Bouche, Michael Frotscher, Frank Henle,
Lutz Hein, Joachim Herz,
Dieter K. Meyer, Marina Pichler, Günter Roth, Carsten Schwan,
and Hans H. Bock
Reelin signals
through apolipoprotein E receptor 2 and Cdc42 to increase growth
cone motility and filopodia formation.
J. Neuroscience 30,14759-72
(2010)
Atsushi Ohazama, Thantrira Porntaveetus, Masato S. Ota, Joachim Herz, Paul T. Sharpe
Lrp4: A novel modulator
of extracellular signaling in craniofacial organogenesis.
Am. J. Medical Genetics Part A 152A, 2974–2983 (2010)
Chantelle F. Sephton, Can Cenik,
Alper Kucukural, Eric B. Dammer, Basar Cenik, YuHong Han,
Colleen M. Dewey, Fritz P. Roth, Joachim Herz, Junmin Peng, Melissa J. Moore,
Gang Yu
Identification of neuronal
RNA targets of TDP-43-containing Ribonucleoprotein complexes.
J. Biol. Chem. 286(2):1204-1215
(2011) [Epub 2010 Nov 4]
Philippe Boucher and Joachim
Herz
Signaling through LRP1:
Protection from atherosclerosis and beyond.
Biochem Pharmacol.
81(1):1-5 (2011) [Epub 2010 Oct 30]
Sangeetha Ramesh, Craig N. Morrell, Cristina Tarango, Gail D.
Thomas, Ivan S. Yuhanna, Guillermina Girardi, Joachim Herz, Rolf T.
Urbanus, Philip G. de Groot, Philip E. Thorpe, Jane E. Salmon,
Philip W. Shaul, Chieko Mineo
Antiphospholipid
antibodies promote leukocyte–endothelial cell adhesion and
thrombosis in mice by antagonizing eNOS via β2GPI and apoER2.
J. Clin. Investigation 121(1):120-131 (2011) [Epub 2010 Dec 1]
Colleen M. Dewey, Basar Cenik,
Chantelle F. Sephton, Daniel R. Dries, Paul Mayer III, Shannon
K. Good, Brett A. Johnson, Joachim
Herz, and Gang Yu
TDP-43 is directed to stress
granules by sorbitol, a novel physiological osmotic and
oxidative stressor.
Mol. Cell. Biol. 31(5):1098-108 (2011) [Epub 2010 Dec 20]
Qiang Liu, Juan Zhang,
Celina Zerbinatti, Yan Zhan, Benedict J. Kolber, Joachim Herz, Louis J.
Muglia, Guojun Bu
Lipoprotein
receptor LRP1 regulates leptin signaling and energy homeostasis
in the adult central nervous system.
PLoS Biol. 9(1):e1000575 (2011)
Huan Long, Hans H. Bock, Ting
Lei, Xuejun Chai, Jihong Yuan, Joachim
Herz, Michael Frotscher, Zaiqing Yang
Identification of
alternatively spliced Dab1 and Fyn isoforms in pig.
BMC Neurosci. 12, 17
(14p) (2011)
Daniel Baitsch, Hans H.
Bock, Thomas Engel, Ralph Telgmann, Carsten Müller-Tidow, Georg
Varga, Martine Bot, Joachim Herz,
Horst Robenek, Arnold von Eckardstein, Jerzy-Roch Nofer
Apolipoprotein E Induces
Antiinflammatory Phenotype in Macrophages.
Arterioscler Thromb Vasc Biol.
31, 1160-1168 (2011)
Fnu Nagajyothi, Louis M. Weiss,
David L. Silver, Mahalia S. Desruisseaux, Philipp E. Scherer, Joachim Herz, Herbert B.
Tanowitz
Trypanosoma cruzi Utilizes
the Host Low Density Lipoprotein Receptor in Invasion.
PLoS Negl Trop Dis. 5(2):e953 (2011)
Haas J, Beer AG, Widschwendter P, Oberdanner J, Salzmann K, Sarg
B, Lindner H, Herz J,
Patsch JR, Marschang P.
LRP1b shows restricted expression
in human tissues and binds to several extracellular ligands,
including fibrinogen and apoE - carrying lipoproteins.
Atherosclerosis 216, 342-347 (2011)
Estelle Woldt, Rachel L. Matz, Jérome Terrand, Mohamed Mlih,
Céline Gracia, Sophie Foppolo, Sophie Martin, Veronique Bruban,
Julie Ji, Emilie Velot, Joachim
Herz, and Philippe Boucher
Differential signaling by
adaptor molecules LRP1-SHCA regulates adipogenesis by the
insulin-like growth factor-1 receptor.
J. Biol. Chem. 286, 16775-16782 (2011)
Basar Cenik, Chantelle F. Sephton, Colleen M. Dewey, Xunde Xian,
Shuguang Wei, Kimberley Yu, Wenze Niu, Giovanni Coppola, Sarah
E. Coughlin, Suzee E. Lee, Daniel R. Dries, Sandra Almeida,
Daniel H. Geschwind, Fen-Biao Gao, Bruce L. Miller, Robert V.
Farese, Jr., Bruce A. Posner, Gang Yu, and Joachim Herz
SAHA (VORINOSTAT)
upregulates progranulin transcription: a rational therapeutic
approach to frontotemporal dementia.
J. Biol. Chem. 286, 16101-16108 (2011)
Justin H. Trotter, Martin
Klein, Umesh K. Jinwal, Jose F. Abisambra, Chad A. Dickey,
Jeremy Tharkur, Irene Masiulis, Jindong Ding, Kirstin G. Locke,
Catherine Bowes Rickman, David G. Birch, Edwin J. Weeber, and Joachim Herz
ApoER2 Function in the
Establishment and Maintenance of Retinal Synaptic
Connectivity.
J. Neuroscience 31, 14413–14423
(2011)
Porntaveetus T, Ohazama A, Choi HY,
Herz J, Sharpe PT.
Wnt signaling in the murine
diastema.
Eur J Orthod. 34, 518-24 (2012)
David M. Holtzman, Joachim Herz, and Goujun Bu
Apolipoprotein E and
Apolipoprotein E Receptors: Normal Biology and Roles in
Alzheimer Disease.
In: The Biology of Alzheimer Disease, Cold Spring Harbor
Laboratory Press, New York, 279-301
Cold Spring Harb Perspect Med. 2012 Mar;2(3):a006312
(2012) PMID: 22393530
Daniel R. Dries, Gang Yu, and Joachim Herz
Extracting β-amyloid from
Alzheimer’s disease.
Proc. Natl. Acad. Sci. 109, 3199-3200 (2012)
Colleen M. Dewey, Basar Cenik, Chantelle F.
Sephton, Brett A. Johnson, Joachim
Herz, Gang Yu
TDP-43 aggregation in
neurodegeneration: are stress granules the key?
Brain Res. 1462, 16-25 (2012)
Chantelle F. Sephton, Basar Cenik,
Bercin K. Cenik, Joachim Herz,
Gang Yu
TDP-43 in central nervous
system development and function: clues to TDP-43-associated
neurodegeneration.
Biol Chem. 393, 589-94 (2012)
Basar Cenik, Chantelle F. Sephton, Bercin K.
Cenik, Joachim Herz,
Gang Yu
Progranulin: a
proteolytically processed protein at the crossroads of
inflammation and neurodegeneration.
J Biol Chem. 287, 32298-32306 (2012)
Yang Du, Marie Yang, Wei Wei,
HoangDinh Huynh, Joachim Herz,
Alan Saghatelian, and Yihong Wan
Macrophage VLDLR receptor
Promotes PAFAH Secretion in Mother's Milk and Suppresses
Systemic Inflammation in Nursing Neonates.
Nature Communications 3, #1008 (2012)
Katsutoshi Sekine, Takeshi Kawauchi, Ken-ichiro Kubo, Takao
Honda, Joachim Herz,
Mitsuharu Hattori, Tatsuo Kinashi, and Kazunori Nakajima
Reelin controls neuronal
migration and positioning by promoting neuronal adhesion to
extracellular matrix via the inside-out activation of integrin
α5β1.
Neuron 76, 353-69 (2012)
Estelle Woldt, Jérome Terrand, Mohamed Mlih, Rachel Matz,
Véronique Bruban, Fanny Coudane, Sophie Foppolo, Zeina El Asmar,
Maria Eugenia Chollet, Ewa Ninio, Audrey Bednarczyk, Danièle
Thiersé, Christine Schaeffer-Reiss, Alain Van Dorsselaer,
Christian Boudier, Walter Wahli, Pierre Chambon, Daniel Metzger,
Joachim Herz, and
Philippe Boucher
PPARγ counteracts
LRP1-induced vascular calcification by inhibiting a Wnt5a
signaling pathway.
Nature Communications 3, #1077 (2012)
Marco Dieckmann, F. Timo Beil, Brigitte Mueller, Alexander
Bartelt, Robert P. Marshall, Till Koehne, Michael Amling,
Wolfgang Ruether, Jackie A. Cooper, Steve E. Humphries, Joachim Herz, and Andreas
Niemeier
Human Apolipoprotein E
Isoforms differentially affect Bone Mass and Turnover in vivo.
Journal of Bone and Mineral Research
28(2):236-45 (2013)
Anne-Sophie Carlo, Camilla Gustafsen, Guido Mastrobuoni, Morten
S. Nielsen, Tilman Burgert, Daniela Hartl, Michael Rohe, Anders
Nykjaer, Joachim Herz, Joerg Heeren, Stefan Kempa, Claus
Munck Petersen, and Thomas E. Willnow
The
pro-neurotrophin receptor sortilin is a major neuronal
apolipoprotein E receptor for catabolism of amyloid-β peptide in
the brain.
J Neurosci.
33(1):358-70
(2013)
Elisabeth Bouché, Mario I. Romero-Ortega, Mark Henkemeyer,
Timothy Catchpole, Jost Leemhuis, Michael Frotscher, Petra May,
Joachim Herz, Hans H. Bock
Reelin
induces EphB activation.
Cell Res.
23(4):473-90
(2013)
Andrew D. Nguyen, Thi A. Nguyen, Basar Cenik, Gang Yu, Joachim
Herz, Tobias C. Walther, W. Sean Davidson, and Robert V.
Farese, Jr.
Secreted
progranulin is a homodimer and is not a component of high density
lipoproteins (HDL).
J
Biol Chem. 288(12):8627-35
(2013)
Xi Chen, Jianjun Chang, Qiudong Deng, Jie Xu, Thi A. Nguyen,
Lauren H. Martens, Basar Cenik, Georgia Taylor, Kathryn F. Hudson,
Jaegwon Chung, Kimberley Yu, Phillip Yu, Joachim Herz,
Robert V. Farese Jr., Thomas Kukar, and Malu´ G. Tansey
Progranulin
Does Not Bind Tumor Necrosis Factor (TNF) Receptors and Is Not a
Direct Regulator of TNF-Dependent Signaling or Bioactivity in
Immune or Neuronal Cells.
J Neurosci. 33(21):9202-9213 (2013)
Chikako Nakajima, Akos Kulik, Michael Frotscher,
Joachim Herz, Michael Schäfer, Hans H. Bock, Petra May
LDL
receptor-related protein 1 (LRP1) modulates N-methyl-D-aspartate
(NMDA) receptor-dependent intracellular signaling and
NMDA-induced regulation of postsynaptic protein complexes.
J Biol Chem.
288(30):21909-23 (2013) Jun 11. [Epub ahead of print]
Pohlkamp T, Dávid C, Cauli B, Gallopin T, Bouché E, Karagiannis A,
May P, Herz J, Frotscher M, Staiger JF, Bock HH.
Characterization
and Distribution of Reelin-Positive Interneuron Subtypes in the
Rat Barrel Cortex.
Cereb
Cortex. 2013 Jun 26. [Epub ahead of print]
Brunne B, Franco S, Bouché E, Herz J,
Howell BW, Pahle J, Müller U, May P, Frotscher M, Bock HH.
Role of the postnatal
radial glial scaffold for the development of the dentate gyrus
as revealed by Reelin signaling mutant mice.
Glia 61(8):1347-63 (2013) Epub Jul 4.
Choi HY, Liu Y, Tennert C, Sugiura Y,
Karakatsani A, Kröger S, Johnson EB, Hammer RE, Lin W, Herz
J.
APP
interacts with LRP4 and agrin to coordinate the development of
the neuromuscular junction in mice.
Elife Aug 20;2:e00220. doi: 10.7554/eLife.00220 (2013)
Gilat-Frenkel M, Boehm-Cagan A, Liraz O, Xian X, Herz J,
Michaelson DM.
Involvement
of the Apoer2 and Lrp1 receptors in mediating the pathological
effects of ApoE4 in vivo.
Curr Alzheimer
Res. 2014;11(6):549-57.
Subramanian M, Hayes CD, Thome JJ, Thorp E,
Matsushima GK, Herz J, Farber DL, Liu K, Lakshmana M,
Tabas I.
An
AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen
cross-presentation in vivo.
J. Clin. Invest. 124(3):1296-308 (2014) Epub Feb 10.
Prabhudas M, Bowdish D, Drickamer K, Febbraio M,
Herz J, Kobzik L, Krieger M, Loike J, Means TK, Moestrup
SK, Post S, Sawamura T, Silverstein S, Wang XY, El Khoury J.
Standardizing
scavenger receptor nomenclature.
J Immunol. 192(5):1997-2006 (2014)
Schorch B, Song S, van Diemen FR, Bock HH, May P,
Herz J, Brummelkamp TR, Papatheodorou P, Aktories K.
LRP1
is a receptor for Clostridium perfringens TpeL toxin indicating
a two-receptor model of clostridial glycosylating toxins.
Proc Natl Acad Sci U S A 111(17):6431-6 (2014) Epub Apr
15.
Pohlkamp T, Steller L, May P, Günther T, Schüle R, Frotscher M, Herz
J, Bock HH.
Generation
and characterization of an Nse-CreERT2 transgenic line suitable
for inducible gene manipulation in cerebellar granule cells.
PLoS One
9(6):e100384 (2014)
Lane-Donovan C, Herz J.
Is
Apolipoprotein E Required for Cognitive Function in Humans?:
Implications for Alzheimer Drug Development.
JAMA Neurol. 2014 Aug 11. [Epub ahead of print]
Lane-Donovan C, Philips GT, Herz J.
More
than Cholesterol Transporters: Lipoprotein Receptors in CNS
Function and Neurodegeneration.
Neuron 83(4):771-787 (2014)
Ward ME, Taubes A, Chen R, Miller BL, Sephton CF, Gelfand JM, Minami
S, Boscardin J, Martens LH, Seeley WW, Yu G, Herz J, Filiano
AJ, Arrant AE, Roberson ED, Kraft TW, Farese RV Jr, Green A, Gan L.
Early
retinal neurodegeneration and impaired Ran-mediated nuclear import
of TDP-43 in progranulin-deficient FTLD.
J.
Exp. Med. 211(10):1937-45 (2014) Epub Aug 25.
Ulrich V, Konaniah ES, Herz J, Gerard RD,
Jung E, Yuhanna IS, Ahmed M, Hui DY, Mineo C, Shaul PW.
Genetic
variants of ApoE and ApoER2 differentially modulate endothelial
function.
Proc Natl Acad Sci U S A 111(37):13493-8 (2014)
Epub Sep 2.
Sephton CF, Tang A, West J, Brooks M, Kulkarni A,
Stubblefield J, Liu Y, Zhang MQ, Green CB, Huber KM, Huang EJ, Herz
J, Yu G
Activity-Dependent FUS
Dysregulation Disrupts Synaptic Homeostasis at Dendritic Spines.
Proc Natl Acad Sci USA
111(44):E4769-78 (2014)
Nakajima C, Haffner P, Goerke SM, Zurhove K, Adelmann G,
Frotscher M, Herz J, Bock HH, May P.
The
lipoprotein receptor LRP1 modulates sphingosine-1-phosphate
signaling and is essential for vascular development.
Development
141(23):4513-25 (2014)
Wasser CR, Masiulis I, Durakoglugil MS, Lane-Donovan C, Xian
X, Beffert U, Agarwala A, Hammer RE, Herz J.
Differential
splicing and glycosylation of Apoer2 alters synaptic plasticity
and fear learning.
Science Signaling
7(353):ra113 (2014)
Interview
Cover
Sharmistha Chakraborty, Li Li, Vineshkumar,
Thidil Puliyaddadamba, Gao Guo, Kimmo J. Hatanpaa, Bruce Mickey,
Rhonda F. Souza, Peggy Vo, Joachim Herz, Mei-Ru Chen,
David A. Boothman, Tej K. Pandita, David H. Wang, Ganes C. Sen,
and Amyn A. Habib
Constitutive and
ligand-induced EGFR signaling trigger distinct and mutually
exclusive downstream signaling networks.
Nat Commun. 5:5811 (2014)
Theresa Pohlkamp, Murat Durakoglugil, Courtney Lane-Donovan,
Xunde Xian, Eric B Johnson, Joachim Herz
Lrp4 domains
differentially regulate limb/brain development and synaptic
plasticity.
PLoS One.10(2):e0116701 (2015).
Jaehong Suh, Juliet A. Moncaster, Lirong Wang, Imran Hafeez, Joachim
Herz, Rudolph E. Tanzi, Lee E. Goldstein, and Suzanne Y.
Guènette
FE65 and FE65L1 amyloid
precursor protein-binding protein compound null mice display
adult-onset cataract and muscle weakness.
FASEB J. 29, 000-000 (2015) Epub Mar 10.
Courtney Lane-Donovan, Gary T. Philips, Catherine R. Wasser,
Murat S. Durakoglugil, Irene Masiulis, Ajeet Upadhaya, Theresa
Pohlkamp, Cagil Coskun, Tiina Kotti, Laura Steller, Robert E.
Hammer, Michael Frotscher, Hans H. Bock, Joachim Herz
Reelin protects
against amyloid-beta toxicity in
vivo.
Sci Signal. 8(384):ra67 (2015).
Suzanne Eldridge, Giovanna Nalesso , Habib Ismail, Karin
Vicente-Greco, Panos Kabouridis, Manoj Ramachandran, Andreas
Niemeier, Joachim Herz, Costantino Pitzalis, Mauro
Perretti, Dell'Accio
Agrin mediates
chondrocyte homeostasis and requires both LRP4 and
alpha-dystroglycan to enhancecartilage formation in vitro and
in vivo.
Ann Rheum Dis. 207316 (2015) Epub Feb. 19.
Catherine Wasser and Joachim Herz
Splicing therapeutics for
Alzheimer's disease.
EMBO Mol Med. e201506067 (2016).
Courtney Lane-Donovan and Joachim Herz
High-Fat Diet
Changes Hippocampal Apolipoprotein E (ApoE) in a Genotype- and
Carbohydrate-Dependent Manner in Mice.
PLoS One. 11(2):e0148099 (2016).
Zeina El Asmar, Jérome Terrand, Marion Jenty, Lionel Host,
Mohamed Mlih, Aurélie Zerr, Hélène Justiniano, Rachel L.
Matz, Christian Boudier, Estelle Scholler, Jean-Marie Garnier,
Diego Bertaccini, Danièle Thiersé, Christine Schaeffer, Alain
Van Dorssselear, Joachim Herz, Véronique Bruban,
Philippe Boucher
Convergent Signaling
Pathways Controlled by LRP1 (LDL Receptor-related Protein 1)
Cytoplasmic and Extracellular Domains Limit Cellular
Cholesterol Accumulation.
J Biol Chem. 291(10):5116-27 (2016) Epub Jan 19.
Victoria Ulrich, Shari E. Gelber, Milena Vukelic, Anastasia
Sacharidou, Joachim Herz, Rolf T. Urbanus, Philip G. de
Groot, David R. Natale, Anirudha Harihara, Patricia
Redecha, Vikki M. Abrahams, Philip W. Shaul, Jane E. Salmon,
Chieko Mineo
ApoE Receptor 2 Mediation
of Trophoblast Dysfunction and Pregnancy Complications Induced
by Antiphospholipid Antibodies in Mice.
Arthritis Rheumatol. 68(3):730-9 (2016).
Yinyuan Ding, Linzhang Huang, Xunde Xian, Ivan S. Yuhanna,
Catherine R. Wasser, Michael Frotscher, Chieko Mineo, Philip W.
Shaul, Joachim Herz
Loss of Reelin protects
against atherosclerosis by reducing leukocyte-endothelial cell
adhesion and lesion macrophage accumulation.
Sci. Signal. 9(419):ra29 (2016).
(updated March 30, 2016)