Publications
Selected Abstracts and Meetings Proceedings:
Eycke Boehme, Christiane Spies, Georg Grossmann, and Joachim Herz
Stimulation of Soluble Guanylate Cyclase by Sydnonimines: Relaxants of
Smooth
Muscle and Inhibitors of Platelet Aggregation.
Naunyn-Schmiedebergs Arch. Pharmacol. 316: 26 (1981)
Joachim Herz, Ute Hamann and
Keith
K. Stanley
A liver mRNA with high sequence homology to the LDL-receptor.
J. Cell Biol. 105, 236a (1987)
Joachim Herz, David Clouthier,
Michael
S. Brown, Joseph L. Goldstein, and Robert E. Hammer
The LDL Receptor Supergene Family.
Keystone Symposia, Supplement 16F, 37 (1992)
Joachim Herz, Robert C. Kowal,
Michael
S. Brown, and Joseph L. Goldstein
Cellular uptake of lipoproteins through LRP is apo E-dependent
J. Drug Devel. 3 (suppl. 1), 71-76 (1990)
Joachim Herz
The Low Density Lipoprotein Receptor-related Protein: An Endocytic
Receptor
with Dual Ligand Specificity.
in "Hepatic Endocytosis of Lipids and Proteins", E. Windler and H.
Greten,
eds., Zuckschwerdt Verlag, pp. 46 - 52 (1992)
Book Contributions:
Thomas E. Willnow and Joachim Herz
Homologous
Recombination for
Gene Replacement in Mouse Cell Lines.
In: Methods in Cell Biology 43: Protein Expression in Animal
Cells.
M. Roth, ed., Academic Press, San Diego, Vol. 43,
305-334
(1994)
Thomas E. Willnow, Shun Ishibashi and
Joachim
Herz
Genetic Manipulation of Lipoprotein Receptors: Implications for
Lipid
Metabolism and Atherosclerosis.
In: Cardiovascular Disease '94: Cellular and Molecular Mechanisms,
Prevention,
Treatment. L. Gallo, ed., Plenum Press, New York, 307-312 (1995)
Thomas E. Willnow and Joachim Herz
Gene Inactivation by Homologous Recombination - Animal Models of Plasma
Lipoprotein
Disorders
Chapter 8, In: Concepts in Gene Therapy. Michael Strauss and John
Barranger,
eds., Walter de Gruyter Berlin, New York, 123-140 (1997)
Joachim Herz
Physiology of the LDL Receptor-Related Protein: Functions in
ApoE-Mediated
Remnant Metabolism and Other Biological Processes
in "Lipoproteins in Health and Disease"; Betteridge, Illingworth, and
Shepherd,
eds., Edward and Arnold, London; Chapter 18, pp. 333-359 (1999)
Joachim Herz, Uwe Beffert,
Thomas
Hiesberger, Michael Gotthardt
ApoE Receptors in the Brain: Novel Signaling Pathways with
Potential
Relevance for Alzheimer’s Disease
In “Research and Perspectives in Alzheimer’s Disease”; Beyreuther,
Christensen,
Masters, eds.; Springer Verlag, Berlin, Heidelberg, Hong Kong,
London,
Milan, Paris, Tokyo (2001)
Joachim Herz
Lipoprotein Receptors.
Encyclopedia of Molecular Medicine, T. Creighton, ed., John Wiley and
Sons
Hans H. Bock, Petra May, Joachim Herz
Lipoprotein
Transport.
In "Transgenic Models in Pharmacology"; Stefan Offermanns, Lutz Hein,
eds.;
Springer Verlag, Berlin, Heidelberg, Hong Kong, London, Milan, Paris,
Tokyo;
Part 4. Cardiovascular System, pp. 397 - 421 (2003)
Hans H. Bock, Joachim Herz,
Petra May
Conditional
AnimalModels for the
Study of LipidMetabolism and Lipid Disorders.
HEP178, 403–435 (2007) - Springer-Verlag Berlin Heidelberg
Hans H. Bock and Joachim Herz
Apolipoprotein E receptor 2 and very low density lipoprotein receptor:
An overview.
In Fatemi, S.H. (ed), Reelin Glycoprotein, Structure, Biology and Roles
in Health and Disease. Springer, New York, pp. 15-35 (2008)
Peer Reviewed Articles:
Eycke Boehme, Rupert Gerzer, Gerd Grossmann, Joachim Herz, Alexander Mülsch,
Cornelie
Spies, and Günter Schultz.
Regulation of Soluble Guanylate Cyclase Activity.
Hormones and Cell Regulation 7, 147-161, (1983)
Eycke Boehme, Georg Grossmann, Joachim
Herz,
Alexander Muelsch, Christiane Spiess, and Günter Schultz
Regulation of cyclic GMP formation by soluble guanylate cyclase:
stimulation
by NO-containing compounds.
Adv. Cyclic Nucleotide Protein Phosphorylation Res. 17:
259-266
(1984)
Harald Haymerle, Joachim Herz,
Giorgio
M. Bressan, Rainer Frank, and Keith K. Stanley
Efficient
construction of cDNA libraries in plasmid expression vectors
using
an adaptor strategy.
Nucleic Acids Res. 14, 8615-8624 (1986)
Keith K. Stanley and Joachim Herz
Topological
mapping of complement component C9 by recombinant DNA techniques
suggests
a novel mechanism for its insertion into target membranes.
EMBO J. 6, 1951-1957 (1987)
Dieter Jenne, Claudine Rey, Daniele Masson, Keith K. Stanley, Joachim Herz, Geert Plaetinck, and
Jürg
Tschopp
cDNA cloning of granzyme C, a granule-associated serine protease
of
cytolytic T lymphocytes.
J. Immunol. 140, 318-323 (1988)
D. Koesling, J. Herz, H.
Gausepohl,
F. Niroomand, K.-D. Hinsch, A. Mülsch, E. Böhme, G. Schultz,
and
R. Frank
The primary structure of the 70 kDa subunit of bovine soluble guanylate
cyclase.
FEBS letters 239 (1): 29-34 (1988)
Joachim Herz, Ute Hamann,
Sissel
Rogne, Ola Myklebost, Heinrich Gausepohl, and Keith K. Stanley
Surface
location and high affinity for calcium of a 500 kd liver membrane
protein
closely related to the LDL receptor suggest a physiological role as
lipoprotein
receptor.
EMBO J. 7, 4119-4127 (1988)
Ola Myklebost, Kristina Arheden, Sissel Rogne, Ad Geurts van Kessel,
Nils
Mandahl, Joachim Herz, Keith
Stanley,
Sverre Heim, and Felix Mitelman
The Gene for the Human Putative apoE Receptor is on Chromosome 12 in
the
Segment q13-14.
Genomics 5, 65-69 (1989)
Ulrike Beisiegel, Wilfried Weber, Gudrun Ihrke, Joachim Herz, and Keith K. Stanley
The
LDL receptor-related
protein, LRP, is an apolipoprotein E-binding
protein.
Nature 341, 162-164 (1989)
Robert C. Kowal, Joachim Herz,
Joseph
L. Goldstein, Victoria Esser, and Michael S. Brown
Low
density lipoprotein receptor-related protein mediates uptake of
cholesteryl
esters derived from apo E-enriched lipoproteins.
Proc. Natl. Acad. Sci. 86, 5810-5814 (1989)
Karin Roemisch, Jane Webb, Joachim
Herz,
Siegfried Prehn, Rainer Frank, Martin Vingron, and Bernhard Dobberstein
Homology
of 54K protein of
signal-recognition particle, docking protein
and
two E.coli proteins with putative GTP-binding domains.
Nature 340, 478-482 (1989)
Heike Kuett, Joachim Herz, and
Keith
K. Stanley
Structure
of the low density lipoprotein receptor-related protein (LRP)
promoter.
Biochem. Biophys. Acta 1009 (3): 229-236 (1989)
Siegfried Prehn, Joachim Herz,
Enno
Hartmann, Teymuras V. Kurzchalia, Rainer Frank, Karin Roemisch,
Bernhard
Dobberstein, and Tom A. Rapoport
Structure and Biosynthesis of the Signal Sequence Receptor.
Eur. J. Biochem. 188, 439-445 (1990)
Joachim Herz, Robert C. Kowal,
Joseph
L. Goldstein, and Michael S. Brown
Proteolytic
processing of the 600 kd low density lipoprotein receptor-related
protein
(LRP) occurs in a trans-Golgi compartment.
EMBO J. 9, 1769-1776 (1990)
Robert C. Kowal, Joachim Herz,
Karl
H. Weisgraber, Robert W. Mahley, Michael S. Brown, and Joseph L.
Goldstein
Opposing
effects of Apolipoproteins E and C on Lipoprotein Binding to Low
Density
Lipoprotein Receptor-related Protein.
J. Biol. Chem. 265, 10771-10779 (1990)
Joachim Herz, Robert C. Kowal,
Y.K.
Ho, Michael S. Brown, and Joseph L. Goldstein
Low
density
lipoprotein receptor-related protein (LRP) mediates endocytosis of
monoclonal
antibodies in cultured cells and rabbit liver.
J. Biol. Chem. 265, 21355-21362 (1990)
Karl H. Weisgraber, Robert W. Mahley, Robert C. Kowal, Joachim Herz, Joseph L. Goldstein,
and
Michael S. Brown
Apolipoprotein C-I Modulates the Interaction of Apolipoprotein E with
ß-Migrating
Very Low Density Lipoproteins (ß-VLDL) and Inhibits Binding of
ß-VLDL
to Low Density Lipoprotein Receptor-related Protein.
J. Biol. Chem. 265, 22453-22459 (1990)
Joachim Herz, Nicholas Flint,
Keith
K. Stanley, Rainer Frank, and Bernhard Dobberstein
The 68 kDa protein of signal recognition particle contains a
glycine-rich
region also found in certain RNA-binding proteins.
FEBS letters 276 (1,2), 103-107 (1990)
Dirk Goerlich, Siegfried Prehn, Enno Hartmann, Joachim Herz, Albrecht Otto, Regine
Kraft,
Martin Wiedmann, Siegne Knespel, Bernhard Dobberstein, and Tom A.
Rapoport
The
Signal Sequence Receptor Has a Second Subunit and Is Part of a
Translocation
Complex in the Endoplasmic Reticulum as Probed by Bifunctional Reagents.
J. Cell Biol. 111, 2283-2294 (1990)
Michael S. Brown, Joachim Herz,
Robert
C. Kowal, and Joseph L. Goldstein
The low density lipoprotein receptor-related protein: double agent or
decoy?
Current Opinion in Lipidology 2, 65-72 (1991)
Joachim Herz, Joseph L.
Goldstein,
Dudley K. Strickland, Y.K. Ho, and Michael S. Brown
39-kDa
Protein Modulates Binding of Ligands to Low Density Lipoprotein
Receptor-related
Protein/a2-Macroglobulin Receptor.
J. Biol. Chem. 266, 21232-21238 (1991)
Kim Orth, Edwin L. Madison, Mary-Jane Gething, Joseph F. Sambrook, and Joachim Herz
Complexes
of t-PA and its serpin inhibitor PAI-1 are internalized via
the
LRP/a2-Macroglobulin Receptor.
Proc. Natl. Acad. Sci. 89, 7422-7426 (1992)
Sylvie Paulien, Avery A. Sandberg, Joachim
Herz, and Robert M. Gemmill
Putative Apolipoprotein Receptor Gene (LRP, a2MR) Is Not Rearranged in
Either
Myxoid Liposarcoma or Lipomas with Translocations in 12q13-14.
Canc. Gen. Cytogen. 60, 125-130 (1992)
Joachim Herz, David E.
Clouthier,
Robert E. Hammer
LDL
Receptor-Related Protein
Internalizes and Degrades uPA/PAI-1
Complexes
and Is Essential for Embryo Implantation.
Cell 71, 411 - 421 (1992) [Correction Cell 73, 428 (1993)]
Thomas E. Willnow, Joseph L. Goldstein, Kim Orth, Michael S. Brown, and
Joachim Herz
Low
Density Lipoprotein Receptor-Related Protein (LRP) and gp330 Bind
Similar
Ligands, Including Plasminogen Activator/Inhibitor Complexes and
Lactoferrin,
An Inhibitor of Chylomicron Remnant Clearance.
J. Biol. Chem. 267, 26172 - 26180 (1992)
Olivier Descamps, David Bilheimer, and Joachim
Herz
Insulin
Stimulates Receptor-mediated Uptake of Apo E-enriched Lipoproteins and
Activated
a2-Macroglobulin in Adipocytes.
J. Biol. Chem. 268, 974 - 981 (1993)
Joachim Herz and Robert D.
Gerard
Adenovirus-mediated
Transfer of Low Density Lipoprotein Receptor Gene Acutely Accelerates
Cholesterol
Clearance In Normal Mice
Proc. Natl. Acad. Sci. 90, 2812-2816 (1993)
Joachim Herz
The LDL Receptor-related Protein - Portrait of a Multifunctional
Receptor.
Current Opinion in Lipidology 4, 107-113 (1993)
Shun Ishibashi, Michael S. Brown, Joseph L. Goldstein, Robert D.
Gerard,
Robert E. Hammer, and Joachim Herz
Hypercholesterolemia
In LDL
Receptor Knockout Mice And Its Reversal By
Adenovirus-Mediated
Gene Transfer.
J. Clin. Invest. 92, 883-893 (1993)
Thomas W. Rosahl, Martin Geppert, Diane Spillane, Joachim Herz, Robert E. Hammer,
Robert
C. Malenka, and Thomas C. Südhof
Short-Term
Plasticity Is Altered
in Mice Lacking Synapsin I.
Cell 75, 661-670 (1993)
Monty Krieger and Joachim Herz
Structures
and Functions of
Multiligand Lipoprotein Receptors:
Macrophage
Scavenger Receptors and LDL Receptor-Related Protein (LRP)
Ann. Rev. Biochem. 63, 601-637 (1994)
Joachim Herz and Thomas E.
Willnow
Functions of the LDL Receptor Gene Family.
Annals N.Y. Acad. Sci. 737, 14-19 (1994)
Thomas E. Willnow and Joachim Herz
Genetic Deficiency in Low Density Lipoprotein Receptor-related Protein
(LRP)
Confers Cellular Resistance to Pseudomonas Exotoxin A - Evidence that
LRP
Is Required for Uptake and Degradation of Multiple Ligands.
J. Cell Science 107, 719-726 (1994)
Shun Ishibashi, Joseph L. Goldstein, Michael S. Brown, Joachim Herz, and Dennis K. Burns
Massive Xanthomatosis and Atherosclerosis in Cholesterol-Fed LDL
Receptor-Negative
Mice.
J. Clin. Invest. 93, 1885-1893 (1994)
Shun Ishibashi, Joachim Herz,
Nobuyo
Maeda, Joseph L. Goldstein, and Michael S. Brown
The
two-receptor model of lipoprotein clearance: Tests of the
hypothesis
in knockout mice lacking the LDL receptor, apoE, and both proteins.
Proc. Natl. Acad. Sci. USA 91, 4431-4435 (1994)
Hiroshi Mokuno, Sandra Brady, Leila Kotite, Joachim Herz, and Richard J. Havel
Effect
of the 39-kDa Receptor-associated Protein on the Hepatic Uptake and
Endocytosis
of Chylomicron Remnants and Low Density Lipoproteins in the Rat.
J. Biol. Chem. 269, 13238-13243 (1994)
Thomas E. Willnow, Kim Orth, and Joachim
Herz
Molecular
Dissection of Ligand Binding Sites on the LDL Receptor-related Protein.
J. Biol. Chem. 269, 15827-15832 (1994)
Thomas E. Willnow, Zeqi Sheng, Shun Ishibashi, and Joachim Herz
Inhibition
of Hepatic
Chylomicron Remnant Uptake by Gene Transfer of A
Receptor
Antagonist.
Science 264, 1471-1474 (1994)
Kim Orth, Thomas Willnow, Joachim Herz,
Mary-Jane Gething, and Joseph Sambrook
Low
Density
Lipoprotein Receptor-related Protein (LRP) Is Necessary for the
Internalization
of Both Tissue-type Plasminogen Activator-Inhibitor-1 (t-PA:PAI-1)
Complexes
and Free Tissue-type Plasminogen Activator (t-PA).
J. Biol. Chem. 269, 21117-21122 (1994)
Shun Ishibashi, Robert E. Hammer, and Joachim
Herz
Asialoglycoprotein Receptor-Deficiency in Mice Lacking the Minor
Receptor
Subunit.
J. Biol. Chem. 269, 27803-27806 (1994)
Wolfgang Poller, Thomas E. Willnow, Jan Hilpert, and Joachim Herz
Differential
Recognition of a1-Antitrypsin/Elastase and a1
-Antichymotrypsin/Cathepsin
G - Complexes by the Low Density Lipoprotein Receptor-related Protein.
J. Biol. Chem. 270, 2841-2845 (1995)
Joachim Herz and Thomas E.
Willnow
Lipoprotein and Receptor Interactions In Vivo.
Current Opinion in Lipidology 6, 97-103 (1995)
Yasunori Osono, Laura A. Woollett, Joachim
Herz, and John M. Dietschy
Role of the Low Density Lipoprotein Receptor in the Flux of Cholesterol
Through
the Plasma and Across the Tissues of the Mouse.
J. Clin. Invest. 95, 1124-1132 (1995)
Thomas E. Willnow, Scott A. Armstrong, Robert E. Hammer, and Joachim Herz
Functional
Expression of Low Density Lipoprotein (LDL) Receptor-related Protein
(LRP)
Is Controlled By Receptor-Associated Protein (RAP) In Vivo.
Proc. Natl. Acad. Sci. USA 92, 4537-4541 (1995)
Joachim Herz, Shi-Qiang Qiu,
Adair
Oesterle, Harshini V. DeSilva, Shahida Shafi, and Richard J. Havel
Initial
hepatic removal of chylomicron remnants is unaffected but endocytosis
is
delayed in mice lacking the low density lipoprotein receptor.
Proc. Natl. Acad. Sci. USA 92, 4611-4615 (1995)
Joachim Herz
Erforschung der Ursachen und Behandlung der Atherosklerose:
Tiermodelle
sind unverzichtbar.
Med-Report 8, 3 (1995)
Thomas W. Rosahl, Diane Spillane, Markus Missler, Joachim Herz, David K. Selig,
Joachim
R. Wolff, Robert E. Hammer, Robert C. Malenka, and Thomas C. Südhof
Essential functions of synapsin I and synapsin II in synaptic vesicle
regulation.
Nature 375, 488- 493 (1995)
Thomas E. Willnow and Joachim Herz
Animal models for disorders of hepatic lipoprotein metabolism.
J. Mol. Med. 73, 213-220 (1995)
Masaaki Narita, Guojun Bu, Joachim
Herz,
and Alan L. Schwartz
Two Receptor Systems are Involved in the Plasma Clearance of
Tissue-type
Plasminogen Activator (t-PA) In Vivo.
J. Clin. Invest. 96, 1164-1168 (1995)
Philip K. Frykman, Michael S. Brown, Tokuo Yamamoto, Joseph L.
Goldstein,
and Joachim Herz
Normal
plasma lipoproteins and fertility in gene-targeted mice homozygous for
a
disruption in the gene encoding very low density lipoprotein receptor.
Proc. Natl. Acad. Sci. USA 92, 8453-8457 (1995)
Masaaki Narita, Guojun Bu, Gillian M. Olins, Darryl A. Higuchi, Joachim Herz, George J. Broze, Jr.,
and
Alan L. Schwartz
Two
Receptor Systems Are Involved in the Plasma Clearance of Tissue Factor
Pathway
Inhibitor in Vivo.
J. Biol. Chem. 270, 24800-24804 (1995)
Laura A. Woollett, Yasunori Osono, Joachim
Herz, and John M. Dietschy
Apolipoprotein
E competitively inhibits receptor-dependent low density lipoprotein
uptake
by the liver but has no effect on cholesterol absorption or sythesis in
the
mouse.
Proc. Natl. Acad. Sci. USA 92, 12500-1504 (1995)
Thomas E. Willnow, Joan M. Moehring, Noel M. Inocencio, Thomas J.
Moehring,
and Joachim Herz
The
low density lipoprotein receptor-related protein (LRP) is processed
by
furin in vivo and in vitro.
Biochemical J. 313, 71-76 (1996)
Thomas E. Willnow, Astrid Rohlmann, Jay Horton, Hideo Otani,
Jürgen
R. Braun, Robert E. Hammer and Joachim
Herz
RAP,
a specialized
chaperone, prevents ligand-induced ER-Retention and
degradation
of LDL receptor-related endocytic receptors.
EMBO J. 15, 2632-2639 (1996)
E. Sehayek, X.X. Wang, I. Vlodavsky, R. Avner, H. Levkovitz, T.
Olivecrona,
G. Olivecrona, T.E. Willnow, J. Herz,
S. Eisenberg
Heparan Sulfate-Dependent and Low Density Lipoprotein Receptor-Related
Protein-Dependent
Catabolic Pathways for Lipoprotein Lipase in Mouse Embryonic
Fibroblasts.
Israel Journal of Medical Sciences 32, 449-454 (1996)
Shun Ishibashi, Margrit Schwarz, Philip K. Frykman, Joachim Herz and David W. Russell
Disruption
of cholesterol 7a-hydroxylase gene in mice. I. Postnatal lethality
reversed
by bile acid and vitamin supplementation.
J. Biol. Chem. 271, 18017-18023 (1996)
Margrit Schwarz, Erik G. Lund, Kenneth D. R. Setchell, Herbert J.
Kayden,
J. E. Zerwekh, Ingemar Bjorkhem, Joachim
Herz and David W. Russell
Disruption
of cholesterol 7a-hydroxylase gene in mice. II. Bile acid deficiency is
overcome
by induction of oxysterol 7a-hydroxylase.
J. Biol. Chem. 271, 18024-18031 (1996)
Thomas E. Willnow, Jan Hilpert, Scottt A. Armstrong, Astrid Rohlmann,
Robert
E. Hammer, Dennis K. Burns and Joachim
Herz
Defective
forebrain development in mice lacking gp330/ megalin.
Proc. Natl. Acad. Sci. USA 93, 8460-8464 (1996)
Jürgen R. Braun, Thomas E. Willnow, Shun Ishibashi, Gilbert
Ashwell,
and Joachim Herz
The
Major
Subunit of the Asialoglycoprotein Receptor is Expressed on the
Hepatocellular
Surface in Mice Lacking the Minor Receptor Subunit.
J. Biol. Chem. 271, 21160-21166 (1996)
Ilka Warshawsky, Joachim Herz,
George
J. Broze, Jr., and Alan L. Schwartz
The Low Density Lipoprotein Receptor-related Protein Can Function
Independently
from Heparan Sulfate Proteoglycans in Tissue Factor Pathway Inhibitor
Endocytosis.
J. Biol. Chem. 271, 25873-25879 (1996)
Photini Sinnis, Thomas E. Willnow, Marcelo R.S. Briones, Joachim Herz, and Victor Nussenzweig
Remnant
Lipoproteins Inhibit Malaria Sporozoite Invasion of Hepatocytes.
J. Exp. Med. 184, 945-954 (1996)
Astrid Rohlmann, Michael Gotthardt, Thomas E. Willnow, Robert E. Hammer
and
Joachim Herz
Sustained
Somatic Gene
Inactivation By Viral Transfer of Cre
Recombinase.
Nature Biotechnology 14, 1562-1565 (1996)
Vardiella L. Meiner, Sylvaine Cases, Heather M. Myers, Eric R. Sande,
Stefano
Bellosta, Morris Schambelan, Robert E. Pitas, James McGuire, Joachim Herz, Robert V. Farese, Jr.
Disruption
of the acyl-CoA:cholesterol acyltransferase gene in mice: Evidence
suggesting
multiple cholesterol esterification enzymes in mammals.
Proc. Natl. Acad. Sci. USA 93, 14041-14046 (1996)
Joachim Herz, Thomas E.
Willnow,
Robert V. Farese, Jr.
Cholesterol, Hedgehog, and embryogenesis.
Nature Genetics 15, 123-124 (1997)
Robert C. Johnson, Susan M. Chapman, Zhao-Ming Dong, Jose M. Ordovas,
Tanya
N. Mayadas, Joachim Herz,
Richard
O. Hynes, Ernst J. Schaefer, and Denisa D. Wagner
Absence
of P-Selectin Delays Fatty Streak Formation in Mice.
J. Clin. Invest. 99, 1037-43 (1997)
Christian Brandes, Sabine Novak, Walter Stockinger, Joachim Herz,Wolfgang J. Schneider,
and
Johannes Nimpf
Avian
and murine LR8B and human apolipoprotein E receptor 2:
differentially
spliced products from corresponding genes.
Genomics 42, 185-91 (1997)
Michael S. Brown, Joachim Herz,
and Joseph L. Goldstein
LDL-Receptor
Structure - Calcium Cages, Acid Baths and Recycling
Receptors.
Nature 388, 629-630 (1997)
Deltef Storm, Joachim Herz,
Peter
Trinder, and Michael Loos
C1-Inhibitor-C1s
Complexes Are Internalized and Degraded by the Low Density Lipoprotein
Receptor-related
Protein.
J. Biol. Chem. 272, 31043-31050 (1997)
Hitoshi Shimano, Iichiro Shimomura, Robert E. Hammer, Joachim Herz, Joseph L. Goldstein,
Michael
S. Brown, and Jay D. Horton
Elevated
Levels of SREBP-2 and Cholesterol Synthesis in Livers of Mice
Homozygous
for a Targeted Disruption of the SREBP-1 Gene.
J. Clin. Invest. 100, 2115-2124 (1997)
Astrid Rohlmann, Michael Gotthardt, Robert E. Hammer, and Joachim Herz
Inducible
Inactivation of Hepatic LRP Gene By Cre-Mediated Recombination Confirms
Role
of LRP in Clearance of Chylomicron Remnants.
J. Clin. Invest. 101, 689-695 (1998)
Robert V. Farese, Jr., and Joachim
Herz
Cholesterol
and Embryogenesis.
Trends in Genetics 14, 115-120 (1998)
Thomas Hiesberger, Silke Hüttler, Astrid Rohlmann, Wolfgang
Schneider,
Konrad Sandhoff, and Joachim Herz
Cellular Uptake of Saposin (SAP) Precursor and Lysosomal Delivery by
the
Low Density Lipoprotein Receptor-Related Protein (LRP)
EMBO J. 17, 4617-4625 (1998)
Murielle M. Véniant, Constance H. Zlot, Rosemary L. Walzem,
Vincenzo
Pierotti, Robert Driscoll, David Dichek, Joachim Herz, and Stephen G. Young
Lipoprotein Clearance Mechanisms in LDL Receptor-Deficient
"Apo-B48-only"
and "Apo-B100-only" Mice
J. Clin. Invest. 102, 1559-1568 (1998)
Marion Trommsdorff, Jean-Paul Borg, Benjamin Margolis, and Joachim Herz
Interaction
of cytosolic adaptor proteins with neuronal apoE receptors and the
amyloid
precursor protein.
J. Biol. Chem. 273, 33556-33560 (1998)
Joachim Herz and Robert V.
Farese,
Jr.
The
LDL Receptor Gene Family, Apolipoprotein B and Cholesterol In Embryonic
Development.
Journal of Nutrition 129, 473S-475S (1999)
Bart J.M. van Vlijmen and Joachim Herz
Gene
Targets and Approaches for Raising HDL.
Circulation 99, 12-14 (1999)
Anders Nykjaer, Duska Dragun, Diego Walther, Henrik Vorum, Christian
Jacobsen,
Joachim Herz, Flemming Melsen,
Erik
Isloe Christensen, and Thomas E. Willnow
An
endocytic pathway essential for renal uptake and activation of the
steroid
25-(OH) vitamin D3.
Cell 96, 507-515 (1999)
Marion Trommsdorff, Michael Gotthardt, Thomas Hiesberger, John Shelton,
Walter
Stockinger, Johannes Nimpf, Robert E. Hammer, James A. Richardson, and Joachim Herz
Reeler/Disabled-Like
Disruption of Neuronal Migration in Knockout Mice Lacking the VLDL
receptor
and ApoE receptor-2.
Cell 97, 689-701 (1999)
Atsushi Sato, Yoshimi Shimada, Joachim
Herz,
Tokuo Yamamoto, and Hisato Jingami
39-kDa
receptor-associated protein (RAP) facilitates secretion and ligand
binding
of extracellular region of very-low-density-lipoprotein receptor:
implications
for a distinct pathway from low-density-lipoprotein receptor.
Biochem. J. 341, 377-383 (1999)
Thomas E. Willnow, Anders Nykjaer, Joachim
Herz
Lipoprotein
receptors: new roles for ancient proteins
Nature Cell Biology 1, 157-162 (1999)
Thomas Hiesberger, Marion Trommsdorff, Brian W. Howell, Andre Goffinet,
Marc
C. Mumby, Jonathan A. Cooper, and
Joachim
Herz
Direct
binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine
phosphorylation
of the adaptor protein Disabled-1 and modulates tau phosphorylation.
Neuron 24, 481-489 (1999)
Bart J.M. van Vlijmen, Astrid Rohlmann, André Bensadoun, Shallee
Page,
I. Sophie T. Bos, Theo J.C. van Berkel, Louis M. Havekes, and Joachim Herz
An
Extrahepatic RAP-Sensitive Mechanism Is Involved in the Metabolism of
Triglyceride-Rich
Lipoproteins.
J. Biol. Chem., 274, 35219–35226 (1999)
Narimon Honarpour, Chunying Du, James A. Richardson, Robert E. Hammer,
Xiaodong
Wang, Joachim Herz
Adult
Apaf-1-Deficient Mice Exhibit Male Infertility.
Developmental Biology 218, 248-258 (2000)
Patricia Marshall, Astrid Rohlmann, Victor Nussenzweig, Joachim Herz, and Photini Sinnis
Plasmodium
Sporozoites Invade Cells with Targeted Deletions in the LDL Receptor
Related
Protein (LRP).
Mol. Biochem. Parasitol. 106, 293-298 (2000)
Joachim Herz, Michael
Gotthardt,
and Thomas E. Willnow
Cellular
Signaling By Lipoprotein Receptors.
Current Opinion in Lipidology 11, 161-166 (2000)
Michael Gotthardt, Marion Trommsdorff, Matthew F. Nevitt, John Shelton,
James
A. Richardson, Walter Stockinger, Johannes Nimpf, and Joachim Herz
Interactions
of the low density lipoprotein (LDL) receptor gene family with
cytosolic
adaptor and scaffold proteins suggest diverse biological functions in
cellular
communication and signal transduction.
J. Biol. Chem. 275, 25616-25624 (2000)
Walter Stockinger, Christian Brandes, Daniela Fasching, Marcela
Hermann,
Michael Gotthardt, Joachim Herz,
Wolfgang J. Schneider, and Johannes Nimpf
The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and 2.
J. Biol. Chem. 275, 25625-25632 (2000)
Joachim Herz and Uwe Beffert
Apolipoprotein
E receptors: linking brain development and Alzheimer disease.
Nature Neuroscience Rev. 1, 51-58 (2000)
Brian W. Howell and Joachim Herz
The
LDL Receptor Gene Family: Signaling Functions in Development.
Current Opinion in Neuroscience 11, 74-81 (2001)
Joachim Herz
Lipoprotein
receptors: Beacons to neurons?
Trends in Neuroscience 24, 193-195 (2001)
Joachim Herz
The
LDL Receptor Gene Family: (Un)Expected Signal Transducers in the Brain
Neuron 29, 571-581 (2001)
Joachim Herz
Deconstructing
the LDL receptor – a rhapsody in pieces
Nature Stuctural Biology 8, 476-8 (2001)
Narimon Honarpour, Katsuhiko Tabuchi, Jeffrey M. Stark, Robert E.
Hammer,
Thomas C. Sudhof, Luis F. Parada, Xiaodong Wang, James A. Richardson,
and
Joachim Herz
Embryonic
neuronal death due to neurotrophin and neurotransmitter deprivation
occurs
independent of Apaf-1.
Neuroscience 106(2):263-74 (2001)
Narimon Honarpour, Sandra Gilbert, Bruce Lahn, Xiaodong Wang, and Joachim Herz
Apaf-1
Deficiency and Neural Tube Closure Defects in forebrain-overgrowth
(fog)
Mice.
Proc. Natl. Acad. Sci., 98(17):9683-7 (2001)
Joachim Herz and Dudley K.
Strickland
LRP:
a multifunctional scavenger and signaling receptor.
J. Clin. Invest. 108(6):779-84 (2001)
Carl Gebhardt, Domenico Del Turco, Alexander Drakew, Albrecht Tielsch, Joachim Herz, Michael Frotscher, and
Thomas
Deller
Abnormal
positioning of granule cells alters afferent fiber distribution in the
mouse
fascia dentata: Morphologic evidence from reeler, apolipoprotein E
receptor
2-, and very low density lipoprotein receptor knockout mice.
J Comp Neurol. 445, 278-92 (2002)
Joachim Herz and Hans. H. Bock
Lipoprotein
Receptors in the Nervous System
Ann. Rev. Biochem. 71, 405-34 (2002)
Philippe Boucher, Pingsheng Liu, Michael Gotthardt, Thomas Hiesberger,
Richard
G. W. Anderson, and Joachim Herz
PDGF
mediates tyrosine phosphorylation of the cytoplasmic domain of the LDL
receptor-related
protein (LRP) in caveolae.
J. Biol. Chem., 277, 15507-13 (2002)
Petra May, Y. Krishna Reddy, and Joachim
Herz
Proteolytic
processing of LRP mediates regulated release of its intracellular
domain.
J. Biol. Chem. 277, 18736-43 (2002)
Rita Holtwick, Michael Gotthardt, Boris Skryabin, Martin
Steinmetz,
Regine Potthast, Bernd Zetsche, Robert E. Hammer, Joachim Herz, and Michaela Kuhn
Smooth
muscle-selective deletion of guanylyl cyclase-A prevents the acute but
not
chronic effects of ANP on blood pressure.
Proc. Natl. Acad. Sci. 99, 7142-7147 (2002)
Alexander Drakew, Thomas Deller, Bernd Heimrich, Carl Gebhardt,
Domenico
Del Turco, Albrecht Tielsch, Eckart Förster, Joachim Herz, and Michael Frotscher
Dentate
Granule Cells in Reeler Mutants and VLDLR and ApoER2 Knockout Mice.
Exp. Neurol. 176, 12-24 (2002)
Edwin J. Weeber, Uwe Beffert, Chris Jones, Jill M. Christian, Eckart
Förster,
J. David Sweatt, and Joachim Herz
Reelin
and ApoE receptors cooperate to enhance hippocampal synaptic plasticity
and
learning.
J Biol Chem., 277, 39944-39952 (2002)
Uwe Beffert, Gerardo Morfini, Hans. H. Bock, Huichuan Reyna, Scott T.
Brady,
and Joachim Herz
Reelin-mediated
signaling locally regulates PKB/Akt and GSK-3ß
J. Biol.Chem. 277, 49958-49964 (2002)
Jochen Brich, Feng-Shiun Shie, Brian W. Howell, Renhua Li, Katalin Tus,
Edward
K. Wakeland, Lee-Way Jin, Marc Mumby, Gary Churchill, Joachim Herz, and Jonathan A. Cooper
Genetic
modulation
of tau phosphorylation in the mouse
J. Neuroscience 23, 187-192
(2003) Alzforum
commentary
Hans H. Bock and Joachim Herz
Reelin
Activates Src Family Tyrosine Kinases in Neurons
Current Biology 13, 18-26 (2003)
Peter Marschang and Joachim Herz
Mouse
models as tools for dissecting disorders of lipoprotein metabolism
Seminars in Cell and Developmental Biology 14, 25-35 (2003)
Michael Gotthardt, Robert E. Hammer, Norbert Hübner, Jan Monti,
Christian
C. Witt, Mark McNabb, James A. Richardson, Henk Granzier, Siegfried
Labeit,
and Joachim Herz
Conditional
expression of mutant M-line titins results in cardiomyopathy with
altered
sarcomere structure.
J Biol Chem. 278, 6059-6065 (2003)
Niels Bovenschen, Joachim Herz,
Jos
M. Grimbergen, Peter J. Lenting, Louis M. Havekes, Koen Mertens, and
Bart
J. M. van Vlijmen
Elevated
plasma factor VIII in a mouse model of low-density lipoprotein receptor
related
protein deficiency
Blood 101, 3933-3939 (2003)
Joachim Herz and Peter Marschang
Coaxing
the LDL Receptor Family into the Fold
Cell 112, 289-292 (2003)
- Marc-Estienne Roehrich, Vincent Mooser, Vincent Lenain, Joachim Herz, Johannes Nimpf, Salman
Azhar,
Martine Bideau, Alessandro Capponi, Pascal Nicod, Jacques-Antoine
Haefliger,
and Gérard Waeber
- Insulin-secreting
ß-cell
dysfunction induced by human lipoproteins
- J. Biol. Chem. 278, 18368-18375 (2003)
Petra May, Hans H. Bock, and Joachim
Herz
Integration
of Endocytosis and Signal Transduction by Lipoprotein Receptors
Sci. STKE 2003, pe12 (2003).
Philippe Boucher, Michael Gotthardt, Wei-Ping Li, Richard G.W.
Anderson,
Joachim Herz
LRP:
Role in Vascular Wall Integrity and Protection from Atherosclerosis
Science 300, 329-332
(2003) Center
Times
Karl Heinz Weiss, Celine Johanssen, Albrecht Tielsch, Joachim Herz, Thomas Deller, Michael
Frotscher,
and Eckart Förster
Malformation
of the Radial Glial Scaffold in the Dentate Gyrus of Reeler Mice,
Scrambler
Mice, and ApoER2/VLDLR-Deficient Mice
Journal of Comparative Neurology 460, 56–65 (2003)
Olav M. Andersen, Ching-Hey Yeung, Henrik Vorum, Maren Wellner,
Thomas
K. Andreassen, Bettina Erdmann, Eva-Christina Mueller, Joachim Herz, Albrecht Otto, Trevor
G.
Cooper, and Thomas E. Willnow
Essential
role of the apolipoprotein E receptor-2 in sperm development.
J. Biol. Chem. 278, 23989-95
(2003)
Peggy C. Stolt, Hyesung Jeon, Hyun Kyu Song, Joachim Herz, Michael J. Eck, and
Stephen
C. Blacklow
Origins
of Peptide Selectivity and Phosphoinositide Binding Revealed by
Structures
of Disabled-1 PTB Domain Complexes.
Structure 11, 569-79
(2003)
Petra May and Joachim Herz
LDL
Receptor-Related
Proteins in Neurodevelopment.
Traffic 4, 291-301 (2003)
Christopher Jones, Robert E. Hammer, Wei-Ping Li, Jonathan C. Cohen,
Helen
H. Hobbs, and Joachim Herz
Normal
Sorting, But Defective Endocytosis of the LDL Receptor in Mice with
Autosomal
Recessive Hypercholesterolemia.
J. Biol. Chem. 278, 29024-29030 (2003)
Petra May, Hans H. Bock, Johannes Nimpf, and Joachim Herz
Differential
Glycosylation Regulates Processing of Lipoprotein Receptors by
gamma-Secretase.
J. Biol. Chem. 278, 37386–37392 (2003)
Eva Hartfuss, Eckart Förster, Hans H. Bock, Michael A. Hack,
Pierre
Leprince, Juan M. Luque, Joachim Herz,
Michael Frotscher, and Magdalena Götz
Reelin
signaling directly affects radial glia morphology and biochemical
maturation.
Development 130, 4597-4609 (2003)
Hans H. Bock, Yves Jossin, Pingsheng Liu, Eckart Förster, Petra
May,
André M. Goffinet, and Joachim
Herz
PI3-Kinase
interacts with the adaptor protein Dab1 in response to Reelin signaling
and
is required for normal cortical lamination.
J. Biol. Chem. 278, 38772–38779 (2003)
Amir H. Assadi, Guangcheng Zhang, Uwe Beffert, Robert S. McNeil, Amy L.
Renfro,
Sanyong Niu, Carlo C. Quattrocchi, Barbara A. Antalffy, Michael
Sheldon,
Dawna D. Armstrong, Anthony Wynshaw-Boris, Joachim Herz, Gabriella D’Arcangelo,
and
Gary D. Clark
Interaction
of reelin signaling and Lis1 in brain development.
Nature Genetics 35, 270-276 (2003)
Joachim Herz
LRP:
a
bright beacon at the blood-brain-barrier
J. Clin. Invest. 112, 1483-1485
(2003)
Uwe Beffert, Peggy C. Stolt, and Joachim
Herz
Functions
of lipoprotein receptors in neurons
Journal of Lipid Research 45, 403–409 (2004)
Marcel Vergés, Andre Bensadoun, Joachim
Herz, John D. Belcher and Richard J. Havel
Endocytosis
of hepatic lipase and lipoprotein lipase into rat liver
hepatocytes
in vivo is mediated by the low density lipoprotein receptor-related
protein.
J. Biol. Chem. 279, 9030-9036 (2004)
Vera Strasser, Daniela Fasching, Christoph Hauser, Harald Mayer, Hans
H.
Bock, Thomas Hiesberger, Joachim Herz, Edwin J. Weeber, J.
David Sweatt,
Albéna Pramatarova, Brian Howell, Wolfgang J. Schneider, and
Johannes
Nimpf
Receptor
Clustering is involved in Reelin signaling.
Mol. Cell. Biol. 24, 1378-1386 (2004)
Yves Jossin, Nina Ignatova, Thomas Hiesberger, Joachim Herz,
Catherine
Lambert de Rouvroit, and André M. Goffinet
The
central fragment of Reelin, generated by proteolytic processing in
vivo,
is critical to its function during cortical plate development.
J. Neuroscience 24, 514 –521 (2004)
Sonia M. S. Espirito Santo, Nuno M. M. Pires, Gery Gerritsen, Niels
Bovenschen, Ko Willems van Dijk, Hans M. G. Princen, André
Bensadoun, Joachim
Herz, Louis M. Havekes, and Bart J. M. van Vlijmen
Hepatic
LDL Receptor-related Protein Deficiency in Mice Increases
Atherosclerosis
Independent of Plasma Cholesterol.
Blood 103, 3777-3782
(2004)
Uwe Beffert, Edwin Weeber, Gerardo Morfini, Jane Ko, Scott T. Brady,
Li-Huei
Tsai, J. David Sweatt, and Joachim Herz
Reelin
and Cdk5 dependent signals cooperate in regulating neuronal
migration
and synaptic transmission.
J. Neuroscience 24, 1897-1906 (2004)
Joachim Herz and David Y. Hui
Lipoprotein
Receptors in the Vascular Wall.
Current Opinion in Lipidology 15, 175-181 (2004)
Peter Marschang, Jochen Brich, Edwin J. Weeber, J. David Sweatt, John
M. Shelton, James A. Richardson, Robert E. Hammer, and Joachim Herz
Normal
Development and Fertility of Knockout Mice Lacking the Tumor Suppressor
Gene LRP1b Suggest Functional Compensation by LRP1.
Mol. Cell. Biol. 24, 3782–3793 (2004)
Hans H. Bock, Yves Jossin, Petra May, Oliver Bergner, and Joachim Herz
Apolipoprotein
E receptors are required for Reelin-induced proteasomal
degradation of the neuronal adaptor protein Disabled-1.
J. Biol. Chem. 279, 33471-33479 (2004)
John D. Minna, Adi F. Gazdar, Stephen R. Sprang, Joachim Herz
A
Bull’s Eye for Targeted Lung Cancer Therapy
Science 304, 1458-1461 (2004)
Petra May, Astrid Rohlmann, Hans H. Bock, Kai Zurhove, Jamey D. Marth,
Eike D. Schomburg, Jeffrey L. Noebels, Uwe Beffert, J. David Sweatt,
Edwin J. Weeber, and Joachim Herz
Neuronal
LRP1 Functionally Associates with Postsynaptic Proteins Is Required for
Normal Motor Function in Mice.
Mol. Cell. Biol. 24, 8872-8883 (2004)
Adi F. Gazdar, Hisayuki Shigematsu, Joachim
Herz, and John D. Minna
Mutations
and addiction to EGFR: the Achilles ‘heal’ of lung cancers?
Trends in Molecular Medicine 10, 481-486 (2004)
Caroline Petit-Turcotte, Nicole Aumont, Uwe Beffert, Doris Dea, Joachim Herz, Judes Poirier
The
apoE receptor apoER2
is involved in the maintenance of efficient synaptic plasticity.
Neurobiology of Aging 26, 195–206 (2005)
Peggy C. Stolt, Ying Chen, Pingsheng Liu, Hans H. Bock, Stephen C.
Blacklow, and Joachim Herz
Phosphoinositide
binding by the
Disabled-1 PTB domain is necessary for membrane localization and Reelin
signal transduction.
J. Biol. Chem. 280, 9671-9677
(2005)
Aparna R. Aiyera, Narimon Honarpour, Joachim
Herz, Deepak Srivastava
Loss
of Apaf-1 leads to partial
rescue of the HAND2-null phenotype.
Dev. Biol. 278, 155-162
(2005)
Hisayuki Shigematsu, Li Lin, Takao Takahashi, Masaharu Nomura, Makoto
Suzuki, Ignacio I. Wistuba, Kwun M. Fong, Huei Lee, Shinichi Toyooka,
Nobuyoshi Shimizu, Takehiko Fujisawa, Ziding Feng, Jack A. Roth, Joachim Herz, John D. Minna, Adi F.
Gazdar
Clinical
and Biological
Features Associated With Epidermal Growth Factor Receptor Gene
Mutations in Lung Cancers.
J. Natl. Cancer
Inst. 97, 339-346 (2005)
Yoshiharu Takayama, Petra May, Richard G. W. Anderson, and Joachim Herz
Low-density
lipoprotein
receptor-related protein 1 (LRP1) controls endocytosis and
c-Cbl-mediated ubiquitination of the platelet-derived growth factor
receptor β (PDGFRβ).
J. Biol. Chem. 280, 18504-18510 (2005)
Uwe Beffert, Edwin J. Weeber, Andre Durudas, Shenfeng Qiu, Irene
Masiulis, J. David Sweatt, Wei-Ping Li, Giselind Adelmann, Michael
Frotscher, Robert E. Hammer, and Joachim
Herz
Modulation
of Synaptic
Plasticity and Memory by Reelin Involves Differential Splicing of the
Lipoprotein Receptor Apoer2.
Neuron 47, 567-579 (2005) Alzforum
Commentary Neuron
Preview
Ying Chen, Uwe Beffert, Mert Ertunc, Tie-Shan Tang, Ege T. Kavalali,
Ilya Bezprozvanny, Joachim Herz
Reelin
Modulates NMDA Receptor
Activity in Cortical Neurons.
J. Neuroscience 25, 8209–8216 (2005)
Hiroshi Kurosu, Masaya Yamamoto, Jeremy D. Clark, Johanne V. Pastor,
Animesh Nandi, Prem Gurnani, Owen P. McGuinness, Hirotaka Chikuda,
Masayuki Yamaguchi, Hiroshi Kawaguchi, Iichiro Shimomura, Yoshiharu
Takayama, Joachim Herz, C.
Ronald Kahn, Kevin P. Rosenblatt, and Makoto
Kuro-o
Suppression
of Aging in Mice by
the Hormone Klotho.
Science 309, 1829-1833
(2005)
Petra May, Joachim Herz, Hans
H. Bock
Molecular
mechanisms of lipoprotein receptor signalling.
Cell Mol Life
Sci. 62, 2325-2338 (2005)
Rita Garuti, Christopher Jones, Wei-Ping Li, Peter Michaely, Joachim Herz, Robert D. Gerard,
Jonathan C. Cohen, Helen H. Hobbs
The
modular adaptor protein ARH promotes LDLR clustering into
clathrin-coated pits.
J. Biol. Chem. 280,
40996-1004 (2005)
Eric B. Johnson, Robert E. Hammer, and Joachim
Herz
Abnormal
development of the
apical ectodermal ridge and polysyndactyly in MEGF7 deficient
mice.
Hum. Mol. Gen. 14, 3523-3538
(2005)
Suzanne Guénette, Yang Chang, Thomas Hiesberger, James A.
Richardson, Christopher B. Eckman, Elizabeth A. Eckman, Robert E.
Hammer and Joachim Herz
Essential
roles for the FE65
amyloid precursor protein-interacting proteins in brain development.
EMBO J. 25, 420-431 (2006)
Uwe Beffert, Andre Durudas, Edwin J. Weeber, Peggy C. Stolt, Klaus M.
Giehl, J. David Sweatt, Robert E. Hammer, and Joachim Herz
Functional
Dissection of Reelin
Signaling by Site-Directed Disruption of Disabled-1 Adaptor Binding to
Apolipoprotein E Receptor 2: Distinct Roles in Development and Synaptic
Plasticity.
J. Neuroscience 26, 2041–2052 (2006)
Chunzhang Cao, Daniel A. Lawrence, Yang Li, Christine A.F. Von Arnim, Joachim Herz, Enming J. Su,
Alexandra Makarova, Bradley T. Hyman, Dudley K. Strickland, and Li Zhang
Endocytic
receptor LRP together with
tPA and PAI-I coordinates Mac-1-dependent macrophage migration.
EMBO J. 25, 1860-1870
(2006)
Xiaobiao Li, Joachim Herz, and
Denis Monard
Activation
of ERK signaling upon
alternative protease nexin-1 internalization mediated by syndecan-1.
J. Cellular Biochemistry 99, 936-951 (2006)
Eric B. Johnson, David J. Steffen, Kristen W. Lynch, and Joachim Herz
Defective
Splicing of
Megf7/Lrp4, a Regulator of Distal Limb
Development, in Autosomal Recessive Mulefoot Disease
Genomics 88, 600-609 (2006)
Joachim Herz
The
Switch on the RAPper's
Necklace...
Molecular Cell 23, 451-455 (2006)
Hu L., Boesten L.S., May P., Herz J.,
Bovenschen N., Huisman M.V., Berbee J.F., Havekes L.M., van Vlijmen
B.J., Tamsma J.T.
Macrophage
Low-Density Lipoprotein
Receptor-Related Protein Deficiency Enhances Atherosclerosis in
ApoE/LDLR Double Knockout Mice
Arterioscler Thromb Vasc Biol. 26, 2710-2715
(2006)
Joachim Herz and Ying Chen
Reelin,
lipoprotein receptors
and synaptic plasticity
Nature Reviews Neuroscience 7, 850-859 (2006)
Uwe Beffert, Farnas Nematollah-Farsian, Irene Masiulis, Robert Hammer,
Sung Ok Yoon, Klaus M. Giehl, and Joachim
Herz
ApoE
receptor 2 controls
neuronal survival the adult brain
Current Biology 16, 2446-2452
(2006)
commentary
Christopher Jones, Rita Garuti, Peter Michaely, Wei-Ping Li, Nobuyo
Maeda, Jonathan C. Cohen, Joachim Herz,
and Helen H. Hobbs
Preservation
of VLDL remnant
clearance attenuates the phenotype of autosomal recessive
hypercholesterolemia
J. Clin. Invest. 117, 165-174 (2007)
Joachim Herz
Overview:
The Long and Winding
Road to Understanding Alzheimer’s Disease.
Neuron 53, 477 - 479 (2007)
Guangcheng Zhang, Amir H. Assadi,
Robert S. McNeil, Uwe Beffert, Anthony Wynshaw-Boris, Joachim Herz, Gary D. Clark, Gabriella D’Arcangelo
The
Pafah1b Complex Interacts
with the Reelin Receptor VLDLR.
PLoS ONE 2, e252, 1-9 (2007) comments
and citations
Philippe Boucher, Wei-Ping Li, Rachel L. Matz, Yoshiharu
Takayama, Johan Auwerx, Richard G.W. Anderson, Joachim Herz
LRP1
Functions as an
Atheroprotective Integrator of TGFβ and PDFG Signals in the Vascular
Wall: Implications for Marfan Syndrome
PLoS ONE 2, e448, 1-7 (2007) comments
and citations
Susanna M. Hofmann, Li Zhou, Diego
Perez-Tilve, Todd Greer, Erin Grant, Lauren Wancata, Andrew Thomas,
Paul T. Pfluger, Joshua E. Basford, Dean Gilham, Joachim Herz, Matthias H.
Tschöp, and David Y. Hui
Adipocyte
LDL receptor related
protein-1 expression modulates postprandial lipid transport, glucose
homeostasis, and adiposity
J. Clin. Invest. 117, 3271-3282 (2007)
Qiang Liu, Celina V. Zerbinatti, Juan Zhang, Hyang-Sook Hoe, Baiping
Wang, Sarah L. Cole, Joachim Herz,
Louis Muglia, and Guojun Bu
Amyloid
Precursor Protein
Regulates Brain Apolipoprotein E and Cholesterol Metabolism through
Lipoprotein Receptor LRP1
Neuron 56, 66-78 (2007)
Alin L. Akopians, Alex H. Babayan, Uwe Beffert, Joachim Herz, Allan I. Basbaum and
Patricia E. Phelps
Contribution
of the Reelin
signaling pathways to nociceptive processing
Eur. J. Neuroscience 27, 523–537 (2008)
Matt Larouche, Uwe Beffert, Joachim Herz, and Richard Hawkes
The
Reelin Receptors Apoer2 and Vldlr Coordinate the Patterning of Purkinje
Cell Topography in the Developing Mouse Cerebellum
PLoS ONE 3, e1653, 1-14 (2008) comments
and citations
Robert Lukowski, Pascal Weinmeister, Dominik Bernhard, Susanne Feil,
Michael Gotthardt, Joachim Herz, Steffen Massberg, Alma
Zernecke, Christian Weber, Franz Hofmann
and Robert Feil
Arterioscler
Thromb Vasc Biol. 28, 1244-1250 (2008)
Joachim Herz, Kym M. Boycott,
Jillian S. Parboosingh
"Devolution"
of bipedality.
Proc Natl Acad Sci U S A. 105, E25
(2008)
Kai Zurhove, Chikako Nakajima, Joachim
Herz, Hans H. Bock, Petra May
γ-Secretase
Limits the
Inflammatory Response Through the Processing of LRP1.
Science Signaling 1, ra15, 1-12 (2008)
Science
Signaling Podcast - Interview
with Petra May
Atsushi Ohazama, Eric B. Johnson,
Masato S. Ota, Hong J. Choi, Thantrira Porntaveetus, Shelly Oommen, Nobuyuki
Itoh, Kazuhiro Eto, Amel Gritli- Linde, Joachim
Herz, and Paul T. Sharpe
Lrp4
modulates extracellular
integration of cell signaling pathways in development.
PLoS ONE 3, e4092,
1-11
(2008) comments
and citations
Joachim Herz, Ying Chen, Irene
Masiulis, Li Zhou
Expanding
Functions of Lipoprotein
Receptors.
J. Lipid Res. 50, S287–S292 (2009)
Jérome Terrand, Véronique
Bruban, Li Zhou, Wanfeng Gong,
Zeina El Asmar, Petra May, Kai Zurhove, Philipp Hafner, Claude
Philippe, Estelle Woldt, Rachel L. Matz, Céline Gracia, Daniel
Metzger, Johan Auwerx, Joachim Herz,
Philippe Boucher
LRP1
controls intracellular
cholesterol storage and fatty acid synthesis through Wnt signaling.
J. Biol. Chem. 284, 381-388 (2009)
Irene Masiulis, Timothy A. Quill, Raymond F. Burk, and Joachim Herz
Differential functions of the Apoer2
intracellular domain in selenium uptake and cell signaling.
Biol. Chem. 390, 67-73 (2009)
Kym M Boycott, Carsten Bonnemann, Joachim Herz, Stephanie Neuert,
Chandree Beaulieu, James N Scott, Anuradha Venkatasubramanian, Jillian
S Parboosingh
Mutations
in VLDLR as a Cause
for Autosomal Recessive Cerebellar Ataxia with Mental Retardation
(Dysequilibrium Syndrome)
J. Child Neurol. 24: 1310-1315 (2009)
Joachim Herz
ApoE
receptors in the nervous
system.
Current Opinion in Lipidology 20, 190-196 (2009)
Murat Durakoglugil, Ying Chen, Charles L. White, Ege T. Kavalali, and Joachim Herz
Reelin
Signaling
Antagonizes β-Amyloid at the
Synapse.
Proc Natl Acad Sci USA 106, 15938–15943 (2009)
Alzforum
commentary Center
Times
Li Zhou, Hong Y. Choi, Wi-Ping Li, Fang Xu, Joachim Herz
LRP1
Controls cPLA2
Phosphorylation, ABCA1 Expression and Cellular Cholesterol Export.
PLoS ONE 4, e6853, 1-9 (2009) comments
and citations
Li Zhou, Yoshiharu Takayama, Philippe Boucher, Michelle D. Tallquist,
Joachim Herz
LRP1
Regulates the Architecture of
the Vascular Wall by Controlling PDGFRβ-Dependent
Phosphatidylinositol 3-Kinase Activation.
PLoS ONE 4, e6922, 1-11
(2009) comments
and citations
Joshua E. Basford, Zachary W.Q. Moore, Li Zhou, Joachim Herz, David Y. Hui
Smooth
Muscle LDL
Receptor-related Protein-1 Inactivation Reduces Vascular Reactivity and
Promotes Injury-induced Neointima Formation.
Arterioscl. Thromb. Vasc. Biol., 29,
1772-1778 (2009)
Mark P. Jedrychowski, Carlos A. Gartner, Steven P. Gygi, Li Zhou, Joachim Herz, Konstantin V. Kandror
and Paul F. Pilch
Proteomic
analysis of GLUT4
storage vesicles (GSVS) reveals low-density lipoprotein
receptor-related protein 1 (LRP1) to be an important vesicle component
and target of insulin signaling.
J Biol Chem. 285(1):104-114 (2010)
[Oct 28, 2009.
[Epub ahead of
print]]
Atsushi Ohazama, James
Blackburn, Thantrira Porntaveetus, Masato Ota, Hong Choi, Eric Johnson,
Philip Myers, Shelly Oommen, Kazuhiro Eto, John Kessler, Takashi Kondo,
Gareth Fraser, J. Todd Streelman, Ulyses Pardiñas, Abigail
Tucker, Pablo Ortiz, Cyril Charles, Laurent Viriot, Joachim Herz, Paul Sharpe
A
role for suppressed incisor
cuspal
morphogenesis in the evolution of mammalian heterodont dentition.
Proc Natl Acad Sci USA 107, 92-97 (2010) [Epub 2009 Dec 14]
Hong Y. Choi, Marco Dieckmann, Joachim
Herz, Andreas Niemeier
Lrp4,
a Novel Receptor for Dickkopf
1 and Sclerostin, Is Expressed by Osteoblasts and Regulates Bone Growth
and Turnover In Vivo.
PLoS ONE 4, e7930, 1-10 (2009) comments
and citations
Chantelle F. Sephton, Shannon K.
Good, Stan Atkin, Colleen M. Dewey, Paul Mayer, Joachim Herz, and Gang Yu
TDP-43
is a
developmentally-regulated protein essential for early embryonic
development.
J. Biol. Chem. 285, 6826-6834 (2010) [Epub 2009 Dec 29]
Martin F. Dietrich, Louise van der Weyden, Haydn M. Prosser, Allan
Bradley, Joachim Herz (corresponding
author), David J. Adams
Ectodomains of the LDL
Receptor-related Proteins LRP1b and LRP4 Have Anchorage-Independent
Functions in Vivo.
PLoS One 5, e9960, 1-7
(2010)
comments and citations
Courtney M. Karner, Martin F. Dietrich, Eric B. Johnson, Natalie
Kappesser, Christian Tennert, Ferda Percin, Bernd Wollnik, Thomas J.
Carroll, Joachim Herz
Lrp4 Regulates Initiation of
Ureteric Budding and Is Crucial
for Kidney Formation – A Mouse Model for Cenani-Lenz Syndrome.
PLoS One 5, e10418, 1-9
(2010) comments
and citations
Yun Li, Barbara Pawlik, Nursel Elcioglu, Mona Aglan, Hülya
Kayserili, Gökhan Yigit, Ferda Percin, Frances Goodman, Gudrun
Nürnberg, Asim Cenani, Jill Urquhart, Boi-Dinh Chung, Samira
Ismail, Khalda Amr, Ayca D. Aslanger, Christian Becker, Christian
Netzer, Pete Scambler, Wafaa Eyaid, Hanan Hamamy, Jill Clayton-Smith,
Raoul Hennekam, Peter Nürnberg, Joachim
Herz, Samia A. Temtamy, and Bernd Wollnik
LRP4 Mutations Alter
Wnt/ß-Catenin
Signaling and
Cause Limb and Kidney Malformations in Cenani-Lenz Syndrome.
The American Journal of Human Genetics
86, 696-706
(2010) [Epub 2010 Apr 8]
Eckart Förster, Hans H. Bock,
Joachim Herz, Xuejun Chai, Michael Frotscher, and Shanting Zhao
Emerging topics in Reelin
function.
European Journal of Neuroscience 31, 1511–1518 (2010)
Ying Chen, Murat
Durakoglugil, Xunde Xian, and Joachim
Herz
ApoE4
reduces glutamate receptor function and synaptic plasticity by
selectively impairing ApoE receptor recycling.
Proc Natl Acad Sci USA 107, 12011-12016 [Epub 2010 Jun 14]
(2010) Alzforum
commentary Center
Times AHAF
Bianka Brunne, Shanting Zhao, Amin
Derouiche, Joachim Herz, Petra
May, Michael Frotscher, Hans H. Bock
Origin,
maturation, and astroglial transformation of secondary radial glial
cells in the developing dentate gyrus.
Glia
58(13):1553-69 (2010) Jun 14. [Epub ahead of print]
Marco
Dieckmann, Martin F. Dietrich, Joachim
Herz
Lipoprotein
receptors--an evolutionarily ancient multifunctional receptor family.
Biological Chemistry 391(11):1341-63
(2010)
Jost Leemhuis, Elisabeth Bouche, Michael Frotscher, Frank Henle, Lutz
Hein, Joachim Herz, Dieter K.
Meyer, Marina Pichler, Günter Roth, Carsten Schwan, and Hans H.
Bock
Reelin signals through
apolipoprotein E receptor 2 and Cdc42 to increase growth cone motility
and filopodia formation.
J. Neuroscience 30,14759-72 (2010)
Atsushi Ohazama, Thantrira Porntaveetus, Masato S. Ota, Joachim Herz, Paul T. Sharpe
Lrp4: A novel modulator of
extracellular signaling in craniofacial organogenesis.
Am. J. Medical Genetics Part A 152A, 2974–2983 (2010)
Chantelle F. Sephton, Can Cenik, Alper
Kucukural, Eric B. Dammer, Basar Cenik, YuHong Han, Colleen M. Dewey,
Fritz P. Roth, Joachim Herz,
Junmin Peng, Melissa J. Moore, Gang Yu
Identification of neuronal RNA
targets of TDP-43-containing Ribonucleoprotein complexes.
J. Biol. Chem. 286(2):1204-1215
(2011)
[Epub 2010 Nov 4]
Philippe Boucher and Joachim Herz
Signaling through LRP1: Protection
from atherosclerosis and beyond.
Biochem Pharmacol. 81(1):1-5
(2011) [Epub 2010 Oct 30]
Sangeetha Ramesh, Craig N. Morrell, Cristina Tarango, Gail D. Thomas,
Ivan S. Yuhanna, Guillermina Girardi, Joachim
Herz, Rolf T. Urbanus,
Philip G. de Groot, Philip E. Thorpe, Jane E. Salmon, Philip W. Shaul,
Chieko Mineo
Antiphospholipid antibodies
promote leukocyte–endothelial cell adhesion and thrombosis in mice by
antagonizing eNOS via β2GPI and apoER2.
J. Clin. Investigation 121(1):120-131 (2011) [Epub 2010 Dec 1]
Colleen M. Dewey, Basar Cenik,
Chantelle F. Sephton, Daniel R. Dries, Paul Mayer III, Shannon K. Good,
Brett A. Johnson, Joachim Herz,
and Gang Yu
TDP-43 is directed to stress
granules by sorbitol, a novel physiological osmotic and oxidative
stressor.
Mol. Cell. Biol. 31(5):1098-108
(2011) [Epub 2010 Dec 20]
Qiang Liu, Juan Zhang, Celina
Zerbinatti, Yan Zhan, Benedict J. Kolber, Joachim Herz, Louis J. Muglia,
Guojun Bu
Lipoprotein
receptor LRP1 regulates leptin signaling and energy homeostasis in the
adult central nervous system.
PLoS Biol. 9(1):e1000575 (2011)
Huan Long, Hans H. Bock, Ting Lei,
Xuejun Chai, Jihong Yuan, Joachim
Herz, Michael Frotscher,
Zaiqing Yang
Identification
of alternatively spliced Dab1 and Fyn isoforms in pig.
BMC Neurosci. 12, 17 (14p)
(2011)
Daniel Baitsch, Hans H. Bock,
Thomas Engel, Ralph Telgmann, Carsten Müller-Tidow, Georg Varga,
Martine Bot, Joachim Herz,
Horst Robenek, Arnold von Eckardstein, Jerzy-Roch Nofer
Apolipoprotein
E Induces Antiinflammatory Phenotype in Macrophages.
Arterioscler Thromb Vasc Biol. 31,
1160-1168 (2011)
Fnu Nagajyothi, Louis M. Weiss,
David L. Silver, Mahalia S. Desruisseaux, Philipp E. Scherer, Joachim Herz, Herbert B. Tanowitz
Trypanosoma cruzi Utilizes the
Host Low Density Lipoprotein Receptor in Invasion.
PLoS Negl Trop Dis. 5(2):e953 (2011)
Haas J, Beer AG, Widschwendter P, Oberdanner J, Salzmann K, Sarg B,
Lindner H, Herz J, Patsch JR,
Marschang P.
LRP1b
shows restricted expression in human tissues and binds to several
extracellular ligands, including fibrinogen and apoE - carrying
lipoproteins.
Atherosclerosis 216, 342-347 (2011)
Estelle Woldt, Rachel L. Matz, Jérome Terrand, Mohamed Mlih,
Céline Gracia, Sophie Foppolo, Sophie Martin, Veronique Bruban,
Julie Ji, Emilie Velot, Joachim Herz,
and Philippe Boucher
Differential signaling by adaptor
molecules LRP1-SHCA regulates adipogenesis by the insulin-like growth
factor-1 receptor.
J. Biol. Chem. 286, 16775-16782 (2011)
Basar Cenik, Chantelle F. Sephton, Colleen M. Dewey, Xunde Xian,
Shuguang Wei, Kimberley Yu, Wenze Niu, Giovanni Coppola, Sarah E.
Coughlin, Suzee E. Lee, Daniel R. Dries, Sandra Almeida, Daniel H.
Geschwind, Fen-Biao Gao, Bruce L. Miller, Robert V. Farese, Jr., Bruce
A. Posner, Gang Yu, and Joachim Herz
SAHA (VORINOSTAT) upregulates
progranulin transcription: a rational therapeutic approach to
frontotemporal dementia.
J. Biol. Chem. 286, 16101-16108 (2011)
Justin H. Trotter, Martin Klein,
Umesh K. Jinwal, Jose F. Abisambra, Chad A. Dickey, Jeremy Tharkur,
Irene Masiulis, Jindong Ding, Kirstin G. Locke, Catherine Bowes
Rickman, David G. Birch, Edwin J. Weeber, and Joachim Herz
ApoER2 Function in the
Establishment and Maintenance of Retinal Synaptic Connectivity.
J. Neuroscience 31, 14413–14423
(2011)
Porntaveetus T, Ohazama A, Choi HY, Herz J, Sharpe PT.
Wnt signaling in the murine diastema.
Eur J Orthod. 34, 518-24 (2012)
David M. Holtzman, Joachim Herz,
and Goujun Bu
Apolipoprotein E and
Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer
Disease.
In: The Biology of Alzheimer Disease, Cold Spring Harbor Laboratory
Press, New York, 279-301
Cold Spring Harb Perspect Med. 2012 Mar;2(3):a006312 (2012) PMID:
22393530
Daniel R. Dries, Gang Yu, and Joachim Herz
Extracting β-amyloid from
Alzheimer’s disease.
Proc. Natl. Acad. Sci. 109, 3199-3200 (2012)
Colleen M. Dewey,
Basar Cenik, Chantelle F. Sephton, Brett A. Johnson, Joachim Herz, Gang Yu
TDP-43 aggregation in
neurodegeneration: are stress granules the key?
Brain Res. 1462, 16-25 (2012)
Chantelle F. Sephton, Basar Cenik, Bercin
K. Cenik, Joachim Herz, Gang Yu
TDP-43
in central nervous system development and function: clues to
TDP-43-associated neurodegeneration.
Biol Chem. 393, 589-94 (2012)
Basar Cenik, Chantelle F. Sephton, Bercin
K. Cenik, Joachim Herz, Gang Yu
Progranulin: a proteolytically
processed protein at the crossroads of inflammation and
neurodegeneration.
J Biol Chem. 287, 32298-32306 (2012)
Yang Du, Marie Yang, Wei Wei,
HoangDinh Huynh, Joachim Herz,
Alan Saghatelian, and Yihong Wan
Macrophage VLDLR receptor Promotes
PAFAH Secretion in Mother's Milk and Suppresses Systemic Inflammation
in Nursing Neonates.
Nature Communications 3, #1008 (2012)
Katsutoshi Sekine, Takeshi Kawauchi, Ken-ichiro Kubo, Takao Honda, Joachim Herz, Mitsuharu Hattori,
Tatsuo Kinashi, and Kazunori Nakajima
Reelin controls neuronal
migration and positioning by promoting neuronal adhesion to
extracellular matrix via the inside-out activation of integrin α5β1.
Neuron 76, 353-69 (2012)
Estelle Woldt, Jérome Terrand, Mohamed Mlih, Rachel Matz,
Véronique Bruban, Fanny Coudane, Sophie Foppolo, Zeina El Asmar,
Maria Eugenia Chollet, Ewa Ninio, Audrey Bednarczyk, Danièle
Thiersé, Christine Schaeffer-Reiss, Alain Van Dorsselaer,
Christian Boudier, Walter Wahli, Pierre Chambon, Daniel Metzger, Joachim Herz, and Philippe Boucher
PPARγ counteracts LRP1-induced
vascular calcification by inhibiting a Wnt5a signaling pathway.
Nature Communications 3, #1077 (2012)
Marco Dieckmann, F. Timo Beil, Brigitte Mueller, Alexander Bartelt,
Robert P. Marshall, Till Koehne, Michael Amling, Wolfgang Ruether,
Jackie A. Cooper, Steve E. Humphries, Joachim
Herz, and Andreas Niemeier
Human Apolipoprotein E
Isoforms differentially affect Bone Mass and Turnover in vivo.
Journal of Bone and Mineral Research, Sep 18. doi: 10.1002/jbmr.1757.
[Epub ahead of print] (2012)
(updated
December 7, 2012)